1. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Fundamentals of Anatomy & Physiology SIXTH EDITION Frederic H. Martini PowerPoint ® Lecture Slide Presentation prepared by Dr. Kathleen A. Ireland, Biology Instructor, Seabury Hall, Maui, Hawaii Chapter 22, part 1 The Lymphatic System and Immunity

2. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Learning Objectives Describe the structure and function of lymphatic cells, tissues and organs List the body’s nonspecific defenses and describe the components and mechanisms of each Define specific resistance and distinguish between cell-mediated immunity and antibody mediated immunity

3. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Learning Objectives Discuss the role of the T cell, B cell and antibodies in specific immunity Describe the origin, development, activation and regulation of normal resistance to disease Discuss the effects of stress and aging on the immune system

4. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings SECTION 22-1 An Overview of the Lymphatic System and Immunity

5. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings The lymphatic system Contains cells, tissues, and organs responsible for defending the body Lymphocytes resist infection and disease by responding to Invading pathogens such as bacteria or viruses Abnormal body cells such as cancer cells Foreign proteins such as toxins lymphatic system

6. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.1 Figure 22.1 The Components of the Lymphatic System

7. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings SECTION 22-2 Organization of the Lymphatic System

8. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Lymph Lymphatic vessels Lymphoid tissues and organs Lymphocytes and supporting phagocytic cells The lymphatic system consists of

9. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Primary function is production, maintenance, and distribution of lymphocytes Lymphocytes must: Detect where problems exist Be able to reach the site of injury or infection Functions of lymphatic system

10. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Lymphatic capillaries Small lymphatic vessels Major lymph-collecting vessels Lymphatic vessels include

11. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.2 Lymphatic Capillaries Figure 22.2a, b

12. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.3 Lymphatic Vessels and Valves Figure 22.3a, b

13. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Superficial and deep lymphatics Thoracic duct Cisterna chyli Right lymphatic duct Major lymph-collecting vessels

14. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.4a Figure 22.4 The Relationship between the Lymphatic Ducts and the Venous System

15. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.4b Figure 22.4 The Relationship between the Lymphatic Ducts and the Venous System

16. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.4c Figure 22.4 The Relationship between the Lymphatic Ducts and the Venous System

17. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Three classes of lymphocytes T (thymus dependent) cells B (bone marrow-derived) cells NK (natural killer) cells Lymphocytes

18. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Involves bone marrow, thymus, and peripheral lymphoid tissue B cells and NK cells mature in bone marrow T cells mature in the thymus Lymphocyte production (lymphopoiesis)

19. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.5a-c Figure 22.5 The Derivation and Distribution of Lymphocytes

20. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Connective tissue dominated by lymphocytes Lymphoid nodules Lymphocytes densely packed in areolar tissue Found in the respiratory, digestive, and urinary tracts MALT (mucosa-associated lymphoid tissue) Collection of lymphoid tissues linked with the digestive system Lymphoid tissue

21. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.6 Lymphoid Nodules Figure 22.6

22. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Lymph nodes – function in the purification of lymph Afferent lymphatics – carry lymph to nodes Efferent lymphatics – carry lymph from nodes Deep cortex dominated by T cells Outer cortex and medulla contains B cells Lymphoid organs

23. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 22.7 The Structure of a Lymph Node Figure 22.7