2. «Technological device for industrial solid-phase synthesis of peptides» “SynChro” Ltd. «Biomac-Innovation» General director “SynCho” Ltd. Dr. Arkavy Igor 127299, Moscow, Klara Zetkin str.4, Phone/fax: +7-095-459-91-35

3. “SynChro” Ltd. Founded in 2004 Team is 8 peoples: 3 scientists 2 engineers 1 technician 1 economist 1 manager

4. “SynChro” Ltd. Founders of “SynChro” Ltd. are: Authors of project from the Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, (Pushchino Moscow region) «Biomac-Innovation» “SynChro” Ltd. legal form is a small enterprise.

5. Synthesis of peptides The automatic solid-phase method for peptides synthesis in automated synthesizers : is the most perspective for manufacturing of peptides; is used by the leading manufacturers of substances and drugs all around the world; is complied with GMP requirements.

6. Advantages of continuous-flow synthesizer Reduction in price of synthesized product by 30% due to: decrease in solvent consumption by more than ten times; decrease in reagent consumption by more than 2-4 times.

7. Laboratory unit The pilot batch of laboratory units for automatic solid- phase peptides synthesis was released in 1999, passed all tests and is using in a work till now days.

8. Key consumers Peptides substances manufacturers for pharmaceutical industry Solid-phase synthesis of peptides with following chromatographic purification Manufacturers of immunobiological drugs Purification of drug substances produced using another methods Use of accessories (column- reactors, taps, pumps) in different technological processes. Research and development organizations and universities Utilization of analytical synthesizer and accessories Rendering of services for solid- phase synthesis and purification of analytical quantities of peptides

9. Russian analogues Positioning on the market Foreign industrial synthesizers of peptides with batch reactors Price: 90.000-350.000 USD Preparative peptides synthesizer with continuous-flow reactor (model) Estimated price is 30.000 USD

10. Basic segments of the world market SegmentQuantity of potential customers Quantity of peptides produced (kg) Annually costs on acquisition of equipment, (million USD) Industrial synthesizers430300 000390 Laboratory synthesizers1 900150140 Organic compounds’ synthesizers 12 000–210 Scientific equipment8 000–300 Rendering of preparative solid-phase synthesis services 280140 000135 Purification of analytical quantity of peptides 200128.5 Total:22 810440 1621 183.5

11. Basic segments of the market in Russia SegmentQuantity of potential customers Quantity of peptides produced (kg) Annually costs on acquisition of equipment, (million USD) Industrial synthesizers6578.0014,5 Laboratory synthesizers2320.12011,1 Organic compounds’ synthesizers 2 300–9,5 Scientific equipment550–10 Rendering of preparative solid-phase synthesis services 18730.000,96 Purification of analytical quantity of peptides 1500.090,54 Total:3 484112.3346,6

12. The present stage of the project Present stageRealization of research and development work (R & D) Present financingThe Foundation for assistance to Small Innovative Enterprises (FASIE) – financing of the first year of research and development work “Biomac-Innovations” (business-incubation of the project) Perspective financing The negotiations are carrying out with a Venture fund about financing the manufacture and creation of technical basis for industrial synthesis and purification peptides custom services. Structural organization of the project The realization of the project is carried out by special founded company ”SynChro” Ltd. Intellectual propertyThe patents for laboratory synthesizer are present. It is planned to take out patents for useful model and key components of the industrial column-reactor synthesizer till May 2005.

13. The present stage and future outlook for project financing Required volume of investments for 3 years $ 2 480 000 Real financing Perspective financing $ 25 000 FASIE Fund (1-st year of R&D) $ 125 000 FASIE Fund (2-nd and 3-rd years of R&D) $ 300 000 Selling of unexceptional licenses $ 1 430 000 Commercial credit From German Bank $ 360 000 Other Russian investments $ 240 000 Subventions from Land Brandenburg

14. The structure of expenditures $ 2 480 000$ 520 000 Licensing Certification Marketing Promotion $ 237 000 – 3 year $ 209 000 – 2 year $ 74 000 – 1 year $ 150 000 R&D $ 75 000 – 3 year $ 50 000 – 2 year $ 25 000 – 1 year $ 1 570 000 Application to production $ 240 000 Peptides purification and technical services $ 237 000 – 2-3 year

15. Suggested business-plan Manufacturing and selling of industrial synthesizers Manufacturing and selling of laboratory synthesizers Rendering services for industrial peptides synthesis and puriffication Rendering services for synthesis and purification of peptides for laboratories Rendering services for purification of olypeptides obtained by another methods (interferon, insulin, oxytocin, etc.) Manufacturing and selling of accessories, having separate application (columns, pumps, etc.) Technologies transfer

16. Next step in project realization There are certain problems with manufacturing and assembling some parts of device in Russia SynChro Ltd. ZABBrainshell Biomac- Innovation Consulting Team Biotechnopark in Berlin/Bran- denburg Technological partner in Germany Russian marketGerman market Joint manufacturing

17. “SynChro” Ltd. & “Biomac-Innovation” Thank You for Your attention