1. About OMICS Group OMICS Group International is an amalgamation of Open Access publications and worldwide international science conferences and events. Established in the year 2007 with the sole aim of making the information on Sciences and technology ‘Open Access’, OMICS Group publishes 400 online open access scholarly journals in all aspects of Science, Engineering, Management and Technology journals. OMICS Group has been instrumental in taking the knowledge on Science & technology to the doorsteps of ordinary men and women. Research Scholars, Students, Libraries, Educational Institutions, Research centers and the industry are main stakeholders that benefitted greatly from this knowledge dissemination. OMICS Group also organizes 300 International conferences annually across the globe, where knowledge transfer takes place through debates, round table discussions, poster presentations, workshops, symposia and exhibitions. Open Access publicationsscholarly journalsInternational conferencesOpen Access publicationsscholarly journalsInternational conferences

2. About OMICS Group Conferences OMICS Group International is a pioneer and leading science event organizer, which publishes around 400 open access journals and conducts over 300 Medical, Clinical, Engineering, Life Sciences, Phrama scientific conferences all over the globe annually with the support of more than 1000 scientific associations and 30,000 editorial board members and 3.5 million followers to its credit. OMICS Group International is a pioneer and leading science event organizer, which publishes around 400 open access journals and conducts over 300 Medical, Clinical, Engineering, Life Sciences, Phrama scientific conferences all over the globe annually with the support of more than 1000 scientific associations and 30,000 editorial board members and 3.5 million followers to its credit. OMICS Group has organized 500 conferences, workshops and national symposiums across the major cities including San Francisco, Las Vegas, San Antonio, Omaha, Orlando, Raleigh, Santa Clara, Chicago, Philadelphia, Baltimore, United Kingdom, Valencia, Dubai, Beijing, Hyderabad, Bengaluru and Mumbai. OMICS Group has organized 500 conferences, workshops and national symposiums across the major cities including San Francisco, Las Vegas, San Antonio, Omaha, Orlando, Raleigh, Santa Clara, Chicago, Philadelphia, Baltimore, United Kingdom, Valencia, Dubai, Beijing, Hyderabad, Bengaluru and Mumbai.

3. camilia.michel@gmail.com

4. Leguminosae (Fabaceae)Economically the Leguminosae (Fabaceae) is one of the most important families of the flowering plants. PterocarpusPterocarpus is a genus representing some of the most handsome large-crowned trees of the leguminous family. 60-70 species.Genus Pterocarpus includes about 60-70 species.

5. Flowering tree in summer

6. Pterocarpus dalbergioides (Roxb) is native to Andaman islands the Andaman islands in the Indian ocean.

7. Egypt ornamental plantIt has been introduced to Egypt as an ornamental plant. Pterocarpus dalbergioides (Roxb) is known as: Andaman padauk East Indian mahogany Andaman redwood Padauk Padauk.

8. AngiospermaePhyllum DicotyledonaeSubphylum Magnoliopsida (Dicotyledons) Class Rosidae Subclass Leguminales (fabales) Order Leguminosae (Fabaceae) Family Papilionoideae Subfamily Dalbergieae Tribe Pterocarpus Genus dalbergioides (Roxb), Roxb. ex DC. Species

9. Outer surface of the stem bark Inner surface of the stem bark

10. Leaf and flower Compound leaf Axillary panicle Flower Flowering branch

11. Seeds Fruiting branch Fruits FruitsFresh Dry Dry

14. Therefore, it was deemed of interest to carry out a bioactivity-guided fractionation study on the different organs of the Egyptian plant, to choose the most active organ, which was not previously investigated.

15. A bioactivity-guided screening of the different organs: Stem bark Stem bark Flower Flower Fruit Leaf Leaf For both antihyperglycemic and anti- inflammatory activies were carried on

17. 0

18. Indomethacin

21. BarkTest - Steam volatile substances ++ Sterols and/or triterpenes ++ Flavonoids a.Free b.Combined - Crystalline sublimate + Carbohydrates and/or glycosides - ++ Tannins a.Catechol b.Pyrogallol - Saponins + Alkaloids and/or nitrogenous bases ---- Anthraquinones a.Free b.Combined - Cardiac glycosides

22. Were carried on and the obtained ethyl acetate and butanol extracts of the were furhtermore subjected to both antihyperglycemic and anti-inflammatory investigation.

23. Antihyperglycemic activity of the ethyl acetate and butanol extracts of the bark, flowers and fruits of Pterocarpus dalbergioides (Roxb)

24. Indomethacin

25. Color with p- anisaldehyde Color with FeCl 3 Color with AlCl 3 Color with NH 3 Color of spot in Butanol bark Ethyl acetat e bark R f in s 4 R f in s 3 No. of spots UVVis.UVVis.UVVis. violet------- - --0.91 pink-------++-0.772 Faint pink---------0.763 violet-------++0.890.744 ----bl.- -++0.810.715 green-fl.gr.br.y.d.y. y.--0.820.456 --d.pr.y.d.pr.br.y.d.pr.f.y.++0.73-7 -bl.s.vi.flY br. s.vi.f l f.y.+±0.718 -----bl.- --0.720.449 --y.br.y.y.br.y.d.pr.f.y.--0.640.4210 green-d.pr.y.d.pr.y.d.pr.y.--0.66-11 --y.br.y.y.br.y.d.pr.f.y.--0.750.3312 violet---------0.680.2513 ----bl.- ---0.42-14 -bl.d.pr.y.d.pr.br.d.pr.f.y.+-0.40.2515 --y.br.y.y.br.y.d.pr.f.y.--0.350.1216 --y. f.y.y.f.br.---0.32-17 green---------0.27-18

26. 10g butanol extract VLC Chloroform Chloroform: ethyl acetate Ethyl acetate : methanol Fractions Each 100 ml TLC monitoring Fraction I (1-10) Fraction II (11-18) CHCl 3 : EtOAc 97:3 85:14 780 mg Fraction III (19-26) Fraction IV (27-36) Fraction V (37-44) CHCl 3 : EtOAc 45:55 30:70 330 mg Fraction VI (45-56) CHCl 3 : EtOAc 25:75 EtOAc 440 mg

27. Pulled fractions (I-VI) Were screened for

31. 10g butanol extract VLC Chloroform Chloroform: ethyl acetate Ethyl acetate : methanol Fractions Each 100 ml Pulled together according to similarity Fraction I (1-10) Fraction II (11-18) Active Fraction III (19-26) Fraction IV (27-36) Fraction V (37-44) Active Fraction VI (45-56) Active P1 23 mg P1 23 mg P2 19 mg P2 19 mg F1 20 mg F1 20 mg CC-Sephadex LH –20 Methanol Methanol :water Increasing polarity Subfractions Further CC –Sephadex LH-20

32. 23 mg off-white needles, soluble in methanol Physical characters 201-203 °C Melting point 259MeOH UV λmax nm

33. M+M+ M + - H 2 O

34. H3 H4 H6 H3 H4 H6 1 23 4 56 Gentisic acid

35. C1 C6 C3 C4C5 C2 COOH 1 2 3 4 56 Gentisic acid

36. 1 23 4 56

37. 20 mg yellowish white powder, soluble in methanol. Physical characters 255-258 °C Melting point 272MeOH UV λmax nm

38. H2, H6 OH (3, 4 &5) 1 5 23 4 6 Gallic acid

39. C2, C6 C1 C4 C3, C5 COOH 1 5 23 4 6 Gallic acid

40. 1 5 23 4 6

41. 19 mg yellow powder, soluble in methanol. Physical characters 265-267°C Melting point 260, 329sh (isoflavone) MeOH UV λmax nm 274, 340 (free OH on ring A & B) NaOMe 271, 300sh, 374 (free OH on ring A) AlCl 3 270, 305sh, 374 (free OH at 5 & no ortho-OH in ring B) AlCl 3 /HCl 262, 328sh (occupied OH at 7) NaoAc 260, 329sh (no ortho-OH in ring B) NaoAc/H 3 Bo 3

42. H8H1’’ H2', 6' H2 H6 H3', 5'

43. C4'C7 C4 C9 C2 C5 C6'' C4'' C5'' C3'' C8 C10 C3', 5' C1' C3 C2', 6' C1’ C6 C2''

46. (1) Vedavanam, K.; Srijayanta, S.; O' Reilly, J.; Raman, A.; Wiseman, H.; "Phytother Res", 13(7), 601- 608,1999. (2) Hung, T.H.W.; Peng, G.; Kota, B.P.; "Toxicology and Applied Pharmacology", 207(2), 160-169, 2005.

48. The ethanolic extract of the bark possessed the most potent antihyperglycemic activity. This effect could be attributed to the synergistic action of the isoflavone and phenolic acid content. The result of the anti-inflammatory activity showed promising evidence for the anti-inflammatory effect of the alcoholic extract of the bark which can be attributed mainly to the phenolic acid content.

51. Acknowledgement Prof. Dr. Moshera M. El Sherei Professor of Pharmacognosy – Faculty of Pharmacy Cairo University Prof. Dr. Wafaa T. Islam Professor of Pharmacognosy – Faculty of Pharmacy Cairo University Mrs Shimaa Rashad Assistant lecturer of Pharmacognosy – Faculty of Pharmacy Cairo University

53.  School of Medicine and Pharmacy was established in Abu Zaabal in 1827.was established in Abu Zaabal in 1827.  It included 25 students for 5 years duration study.duration study.

54.  In 1955, Faculty of Pharmacy was separated as one of the Cairo University.  In 1970, the first internal bylaws was issued.  In 1993, bylaws was amended to include two semesters system and the cumulative average of the Bachelor.

59. Lets Meet again at Pharmacognosy-2015 3 rd International Conference and Exhibition on Pharmacognosy, Phytochemistry and Natural Products October 26-28, 2015 Hyderabad, India Theme: Advanced trends for the future of Herbal Drugs and Products Website: http://pharmacognosy-phytochemistry-natural- products.pharmaceuticalconferences.com/ http://pharmacognosy-phytochemistry-natural- products.pharmaceuticalconferences.com/http://pharmacognosy-phytochemistry-natural- products.pharmaceuticalconferences.com/