1. Slide Source: Lipids Online Slide Library www.lipidsonline.org 56 healthy premenopausal obese women (aged 25–44 years) compared with 40 age-matched nonobese women at baseline 56 healthy premenopausal obese women (aged 25–44 years) compared with 40 age-matched nonobese women at baseline Obese women treated with multidisciplinary approach including diet, exercise, behavioral and nutritional counseling, and liposuction surgery Obese women treated with multidisciplinary approach including diet, exercise, behavioral and nutritional counseling, and liposuction surgery Follow-up at 12 months in obese women, after decrease of 10% of body weight (mean 21.6 ± 3.3 lb, range 16.5–28.6 lb) Follow-up at 12 months in obese women, after decrease of 10% of body weight (mean 21.6 ± 3.3 lb, range 16.5–28.6 lb) Inflammatory Markers and Endothelial Function in Obesity and after Weight Loss Ziccardi P et al. Circulation 2002;105:804-809.

2. Slide Source: Lipids Online Slide Library www.lipidsonline.org Baseline Characteristics Obese (n=56) Nonobese (n=40) p Age, y 35.3 ± 4.8 34.1 ± 5.2 NS BMI, kg/m 2 37.2 ± 2.2 23.5 ± 1.7 <.001 Waist/hip ratio 0.84 ± 0.06 0.72 ±0.05 <.001 SBP, mm Hg 123.3 ± 6.2 121.7 ± 5.3 NS DBP, mm Hg 83.5 ± 3.9 82.1 ± 3.7 NS Fasting glucose, mg/dL 99.1 ± 7.2 88.3 ± 5.4 <.05 Fasting insulin, U/mL 16.6 ± 5.4 9.8 ± 3.3 <.02 LDL-C, mg/dL 131.5 ± 15.5 127.6 ± 15.5 NS HDL-C, mg/dL 38.7 ± 7.7 42.5 ± 7.7 NS Triglycerides, mg/dL 132.9 ± 26.6 115.1 ± 17.7 NS Ziccardi P et al. Circulation 2002;105:804-809.

3. Slide Source: Lipids Online Slide Library www.lipidsonline.org Effects of Obesity and Weight Loss on Inflammatory Markers Nonobese Obese/12 months Obese/baseline ng/mL pg/mL Ziccardi P et al. Circulation 2002;105:804-809. P-selectinVCAM-1ICAM-1 TNF- IL-6 *p<.01 vs nonobese and 12 months *p<.01 vs nonobese and 12 months **p<.02 vs nonobese and 12 months * ** * *

4. Slide Source: Lipids Online Slide Library www.lipidsonline.org Effects of Obesity and Weight Loss on Fasting Glucose and Fasting Insulin mg/dL U/mL Ziccardi P et al. Circulation 2002;105:804-809. Nonobese Obese/12 months Obese/baseline *p<.05 vs nonobese and 12 months **p<.02 vs nonobese and 12 months 88.3 99.1 91.9 9.8 16.6 12.9 * **

5. Slide Source: Lipids Online Slide Library www.lipidsonline.org Effects of Obesity and Weight Loss on Endothelial Function Nonobese Obese/12 months Obese/baseline Ziccardi P et al. Circulation 2002;105:804-809. Mean BP (mm Hg) Platelet aggregation (%) Blood viscosity (cp) Decrease with L-Arginine *p<.01 vs nonobese and 12 months *p<.01 vs nonobese and 12 months **p<.05 vs nonobese, p<.02 vs 12 months * **