1. 1 Baseline BMI and Age-Adjusted Incidence of Diabetes Mellitus White Men Level of BMI Percent 35 30 25 20 15 10 5 0 <20<23<26 <29 <3232 Black Men Level of BMI Percent 35 30 25 20 15 10 5 0 <20<23<26<29<3232 White Women Level of BMI Percent 35 30 25 20 15 10 5 0 <20<23<26 <29 <3232 Black Women Level of BMI Percent 35 30 25 20 15 10 5 0 <20<23 <26 <29<3232 NHANES I Epidemiologic Follow-up Study. 1971-1987. Lipton R.B. et al. Am J Epidemiol 1993;138:826-39. Bars: frequency distribution of body mass index (BMI). Squares and lines: incidence of diabetes (%).

2. 2 Obesity and Diabetes Risk BMI Levels Incidence of New Cases per 1,000 Person-Years Knowler WC et al. Am J Epidemiol 1981;113:144-156.

3. 3 Weight Gain and Diabetes Risk Body Mass Index at Age 21 Relative Risk Weight Change Since Age 21 Adapted from Chan JM et al. Diabetes Care 1994;17:960-969.

4. 4 Metabolic Characteristics of Non-Obese and Obese Women With Low and High Levels of Deep Abdominal Fat Despres JP et al. Arteriosclerosis 1990;10:497-511. *Significantly different from non-obese women. +Significantly different from obese women with low levels of deep abdominal fat, p<0.05. The values represent means + SD. The number of subjects is shown in parentheses. Triglyceride data were log 10 transformed for statistical analysis.

5. 5 26 -Year Incidence of Coronary Heart Disease in Men Incidence/1,000 BMI Levels Adapted from Hubert HB et al. Circulation 1983;67:968-977. Metropolitan Relative Weight of 110 is a BMI of approximately 25.

6. 6 26 -Year Incidence of Coronary Heart Disease in Women Incidence/1,000 BMI Levels Adapted from Hubert HB et al. Circulation 1983;67:968-977. Metropolitan Relative Weight of 110 is a BMI of approximately 25.

7. 7 Relationship of BMI to Excess Mortality 300 Age at Issue Bray GA. Overweight is risking fate. Definition, classification, prevalence and risks. Ann NY Acad Sci 1987;499:14-28. 20-29 250 Mortality Ratio Body Mass Index (kg/[m 2 ]) 200 150 100 50 15 0 30-39 202530 Low Risk 4035 High Risk Moderate Risk