1. Izak, M.G.J., Cizmarova-Izakova, A., Nikel, J., Gablasova, K., Bielikova, A. Izak, M.G.J., Cizmarova-Izakova, A., Nikel, J., Gablasova, K., Bielikova, A. ASCRS 2009 San Francisco Eye Clinic F. D. Roosevelt Hospital Banska Bystrica, Slovakia Slovak Healthcare University Head: Prof. Milan G. J. I Z A K, M.D., PhD., FEBO Eye Clinic F. D. Roosevelt Hospital Banska Bystrica, Slovakia Slovak Healthcare University Head: Prof. Milan G. J. I Z A K, M.D., PhD., FEBO

2. Disclosure: The authors do not have any financial interest in material or methods mentioned.

3. 234 Eyes 149 Patients 1993-2007 ARTISAN Myopia PIOL implantation Follow-up time: 1 - 14 y. (  = 8.4 y. ) Eye Clinic F. D. Roosevelt Hospital, Banská Bystrica, SLOVAKIA ♀ 93 ( 62.4% ) ♂ 56 ( 37.6% ) Age: 18 - 50 y. (  = 29.7 y. )

4. ARTISAN Myopia PIOL implantation (1993-2007) ARTISAN Myopia PIOL implantation (1993-2007) Cataract incidence Eye Clinic F. D. Roosevelt Hospital, Banská Bystrica, SLOVAKIA Cataract ARTISAN non related No. Patients No. Eyes Cataract ARTISAN related 149 (100%) 234 (100%) 1 (0.42%) 14 (6.0%) 15 (6.41%) Cataract incidence after ARTISAN Myopia PIOL impl. Cataract incidence after ARTISAN Myopia PIOL impl.

5. Final BCVA: 0.1 ( Refr.: PLAN = -2.0 cyl. Spher. equiv.: -1.0 Dptr. ) 0.1 ( Refr.: PLAN = -2.0 cyl. Spher. equiv.: -1.0 Dptr. ) Eye Clinic F. D. Roosevelt Hospital, Banská Bystrica, SLOVAKIA ARTISAN RELATED CATARACT ARTISAN RELATED CATARACT 1 Pat. (0.67%) 1 Pat. (0.67%) 1 Eye (0.42%) 1 Eye (0.42%) 1 year later: retinal detachment, RD surgery 2 years later- cataract due to rubbing of the lens capsule caused by horizontal tilting of ARTISAN ARTISAN PIOL EXPL. WITH CONSEQ. CATARACT SURG. 2 years later- cataract due to rubbing of the lens capsule caused by horizontal tilting of ARTISAN ARTISAN PIOL EXPL. WITH CONSEQ. CATARACT SURG. Pat. H.F.: ♂, 20 years of age at the time of ARTISAN impl.

6. Eye Clinic F. D. Roosevelt Hospital, Banská Bystrica, SLOVAKIA ARTISAN NON RELATED CATARACT ARTISAN NON RELATED CATARACT 12 Pat. (8.1%) 12 Pat. (8.1%) 14 Eyes (6.0%) 14 Eyes (6.0%) ARTISAN PIOL EXPLANTATION AND CONSEQUENT CATARACT SURGERY ARTISAN PIOL EXPLANTATION AND CONSEQUENT CATARACT SURGERY

7. Eye Clinic F. D. Roosevelt Hospital, Banská Bystrica, SLOVAKIA Time from ARTISAN Myopia PIOL implantation to expl. and conseq. cataract surg. Time from ARTISAN Myopia PIOL implantation to expl. and conseq. cataract surg. 13 y. Ø = 8.3 y. 5 y. Age at the ARTISAN Myopia PIOL implantation Age at the ARTISAN Myopia PIOL implantation 49 y. Ø = 40.1 y. 20 y. from to fromto ARTISAN NON RELATED CATARACT (14 eyes)

8. Eye Clinic F. D. Roosevelt Hospital, Banská Bystrica, SLOVAKIA BCVA before ARTISAN Myopia PIOL implantation BCVA before ARTISAN Myopia PIOL implantation 0.8 Ø = 0.57 0.2 Myopic refraction before ARTISAN Myopia PIOL implantation (sph.eq.) Myopic refraction before ARTISAN Myopia PIOL implantation (sph.eq.) -17.5 Ø = -14.1 -7.5 from to fromto ARTISAN NON RELATED CATARACT (14 eyes)

9. ARTISAN PIOL EXPLANTATION WITH CONSEQ. CAT. SURG. ARTISAN PIOL EXPLANTATION WITH CONSEQ. CAT. SURG. - without PC IOL implantation Eye Clinic F. D. Roosevelt Hospital, Banská Bystrica, SLOVAKIA No. Eyes - secondary PC IOL implatation 14 1 1 8 8 - with PC IOL implantation 5 5 ARTISAN NON RELATED CATARACT

10. Eye Clinic F. D. Roosevelt Hospital, Banská Bystrica, SLOVAKIA BCVA after ARTISAN Myopia PIOL explantation and conseq. cataract surg. BCVA after ARTISAN Myopia PIOL explantation and conseq. cataract surg. 1.0 Ø = 0.75 0.2 Refraction after ARTISAN Myopia PIOL explantation and conseq. cat. surg. (sph.eq.) Refraction after ARTISAN Myopia PIOL explantation and conseq. cat. surg. (sph.eq.) -4.75 Ø 2 = -2.83 +2.25 from to fromto Ø 1 = +1.12 ARTISAN NON RELATED CATARACT (14 eyes)

11. - regenerative cataract Complications postoperative : Eye Clinic F. D. Roosevelt Hospital, Banská Bystrica, SLOVAKIA No. Eyes - CNV ( PDT Th ) 0 0 1 ( BCVA 0.2 ) Complications peroperative : - others 2 2 - - - retinal detachment - - ARTISAN NON RELATED CATARACT (14 eyes)

12. Eye Clinic F. D. Roosevelt Hospital, Banská Bystrica, SLOVAKIA Conclusion 2. The incidence of ARTISAN NON RELATED CATARACT in myopic patient was 6.4%. 2. The incidence of ARTISAN NON RELATED CATARACT in myopic patient was 6.4%. 3. Consequent cataract surgery after previous ARTISAN Myopia PIOL implantation can restore very good visual acuity again. 3. Consequent cataract surgery after previous ARTISAN Myopia PIOL implantation can restore very good visual acuity again. 1. 1. Our 8.4 years follow-up proves very rare incidence of ARTISAN RELATED CATARACT ( 0.4% ). 1. 1. Our 8.4 years follow-up proves very rare incidence of ARTISAN RELATED CATARACT ( 0.4% ).