1. 12 May 2015 ACR TRIAD IMAGE MANAGEMENT SYSTEM NCI CQIE – Centers of Quantitative Imaging Excellence Program NCI Centers of Quantitative Imaging Excellence Program Jim Gimpel RT (R)(MR) Imaging Analyst ACR Clinical Research Center

2. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program

3. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program Centers of Quantitative Imaging Excellence Program (CQIE) To be conducted at 50+ NCI Cancer Centers nationwide Annual renewal program Training and qualification in advanced, quantitative imaging for CT, MRI and PET On-site and on-line training components

4. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program NCI Cancer Centers source: cancer.gov GROUP 1 Abramson Cancer Center City of Hope National Medical Center USC Norris Comprehensive Cancer Center UC Davis Cancer Center University of Colorado Cancer Center H. Lee Moffitt Cancer Center Winship Cancer Institute University of Chicago Comprehensive Cancer Center Sidney Kimmel Comprehensive Cancer Center Greenebaum Cancer Center The Barbara Ann Karmanos Cancer Institute University of Michigan Comprehensive Cancer Center Mayo Clinic Cancer Center

5. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program NCI Cancer Centers source: cancer.gov GROUP 1 Siteman Cancer Center UNC Lineberger Comprehensive Cancer Center Memorial Sloan-Kettering Cancer Center Albert Einstein Cancer Center (Montefiore) NYU Cancer Institute Herbert Irving Comprehensive Cancer Center OSU-James Comprehensive Cancer Center Fox Chase Cancer Center University of Pittsburgh Cancer Institute Vanderbilt -Ingram Cancer Center M.D. Anderson Cancer Center Massey Cancer Center UW Paul P. Carbone Comprehensive Cancer Center

6. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program NCI Cancer Centers source: cancer.gov GROUP 2 UAB Comprehensive Cancer Center Arizona Cancer Center Chao Family Comprehensive Cancer Center Jonsson Comprehensive Cancer Center Moores Cancer Center Stanford Cancer Center UCSF Helen Diller Family Comprehensive Cancer Center Yale Cancer Center Lombardi Comprehensive Cancer Center Cancer Research Center of Hawaii Holden Comprehensive Cancer Center Robert H. Lurie Comprehensive Cancer Center Indiana University Melvin and Bren Simon Cancer Center Dana-Farber/Harvard Cancer Center Masonic Cancer Center Duke Comprehensive Cancer Center

7. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program NCI Cancer Centers source: cancer.gov GROUP 2 Wake Forest Comprehensive Cancer Center Norris Cotton Cancer Center The Cancer Institute of New Jersey University of New Mexico Cancer Research & Treatment Center Roswell Park Cancer Institute Case Comprehensive Cancer Center OHSU Knight Cancer Institute Kimmel Cancer Center Hollings Cancer Center St. Jude Children ’ s Research Hospital Dan L. Duncan Cancer Center Cancer Therapy & Research Center Huntsman Cancer Institute UVA Cancer Center Fred Hutchinson Cancer Research Center

8. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program Training to be “Trial-ready” Scanning for Qualification ACR Accreditation scans for all modalities, plus CTMRIPET Volumetric (Body) Volumetric (Brain) DCE-MRI (Brain/Body) Static (Brain) Dynamic (Brain/Body)

9. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program ACR CT Phantom Scans CQIE Volumetric Protocol Scan (HRCT) CT Volumetric (Body)

10. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program ACR MRI Phantom Scans CQIE Volumetric Scan Diffusion In Vivo Scan DCE-MRI Brain DCE-MRI Body MRI Volumetric (Brain) DCE-MRI (Brain/Body)

11. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program ACR Whole Body/Brain Scans In Vivo test case Uniform Phantom Whole Body/Brain/Dynamic Scans PET Static (Brain) Dynamic (Brain/Body)

12. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program Site Qualification Process  Site Initiation Packet sent to site  Execution of a participation agreement (MOU)  Submission of the Site Assessment Form  Completion of CQIE Web Learning Modules  Site Visit (first year)  MR/CT Site Visit (2 consecutive days, ~4 hours each)  PET Site Visit (~4 hours)  Site submission of a CQIE Application

13. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program Site Qualification Process (cont’d)  Images and Data Form submissions  Evaluation of images and data (ACRIN)  Notification of results  Site compensation  Qualification imaging is performed  Annual renewal (site responsibility!)

14. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program Site Initiation

15. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program Imaging

16. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program Evaluation

17. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program National Cancer Institute Roles:  Committed funding to support CQIE development of qualification guidelines and the process to qualify cancer centers  NCI will maintain oversight for the project  Will serve as a liaison to the cancer center community

18. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program ACRIN Roles:  Development and dissemination of the CQIE qualification requirements and managing the qualification process  Maintain a Manual of Procedures (MOP) to serve as a resource for participating cancer centers  Develop and maintain the training curriculum  Provide assistance with obtaining phantoms

19. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program  Administer a one-time payment to each CQIE qualified cancer center  Create a list of qualified CQIE sites that will be published on both the ACRIN and NCI web sites  At the direction of the NCI, perform annual requalification of participating institutions

20. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program

21. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program  Cancer centers will need to execute the CQIE Memorandum of Understanding (MOU)  Each site is asked to identify a project leader to serve as the primary point of contact with ACRIN  Project leader will help coordinate and oversee the qualification activities at the site Site Roles

22. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program  Active participation and an ongoing commitment from all three imaging modalities (MR, CT and PET).  Completion of on-line learning modules  Submission of the required test case images  CQIE specified phantom scans  Attest to required ongoing Quality Control (QC) activities Site Roles

23. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program  Annual acquisition and submission of qualification imaging  Be committed to completing the qualification process expeditiously  Must agree to conduct annual requalification for 3 years Site Roles

24. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program www.acrin.org/NCI-CQIE.aspx ACRIN.ORG

25. ACR TRIAD IMAGE MANAGEMENT SYSTEM Divider (sub-section) Slide NCI – CQIE Program NCI CQIE – Centers of Quantitative Imaging Excellence Program Project ManagerDeborah Harbison CQIE-Manager@acr-arrs.org Project Support Sheryia Scott sscott@acr-arrs.org CT Imaging James Gimpel CQIE-MR-CT@acr-arrs.org Frank McCoy MR Imaging James Gimpel CQIE-MR-CT@acr-arrs.org Frank McCoy PET Imaging Adam Opanowski CQIE-PET@acr-arrs.org Amanda Griffith Project PhysicistMehdi Adineh madineh@acr-arrs.org

26. 12 May 2015 ACR TRIAD IMAGE MANAGEMENT SYSTEM NCI CQIE – Centers of Quantitative Imaging Excellence Program Jim Gimpel RT (R)(MR) Imaging Analyst ACR Clinical Research Center