1. CLINICAL & TRANSLATIONAL SCIENCE AWARDS CLINICAL & TRANSLATIONAL SCIENCE AWARDS Transforming Biomedical Research To Improve the Health of Our Nation’s People Donna Jo McCloskey, Ph.D., RN Program Officer Clinical Division National Center for Research Resources mccloskd@mail.nih.gov

2. Impetus for the CTSA Program Integrative  Across health disciplines  Between scientific areas  Into the community  engagement/participation Translational  Laboratory to Clinic to Community to Laboratory Educational  Scientists  Health care providers  Community Provides resource infrastructure  NIH funded research  Non-NIH funded research  Public-private partnership

3. Clinical and Translational Science Award (U54) RFA-RM-006-002  Trans-NIH collaboration  First RFA released October, 2005 reviewed in summer of 2006 for October 2006 funding  U54 mechanism Cooperative agreement between awardee academic institution and NIH Multi-faceted research program Complex award mechanism: Combined U54, T32 and K12 5 year award

4. MT WY ID WA OR NV UT CA AZ ND SD NE CO NM TX OK KS AR LA MO IA MN WI IL IN KY TN MS AL GA SC VA WV MI PA NJ MA ME VT NH AK HI UC, Davis Duke UCSF University of Rochester OHSU UT, Houston Mayo Clinic Columbia Yale OH University of Washington Emory University of Iowa University of Michigan Washington University, St. Louis Vanderbilt Weill Cornell FL Since 2007 Since 2006 University of Chicago Rockefeller University of Pennsylvania Johns Hopkins UT Southwestern Case Western Reserve NY University of Wisconsin Participating Institutions University of Pittsburgh Building a National CTSA Consortium Stanford Scripps Univ. of Utah Univ. of Colorado Harvard Boston University Tufts University OSU UNC Univ of Alabama at Birmingham Indiana University Northwestern UT San Antonio Albert Einstein Since 2008

5. Trial Design Advanced Degree-Granting Programs Participant & Community Involvement Regulatory Support Biostatistics Clinical Resources Biomedical Informatics Clinical Research Ethics CTSA Academic Center NIH & other government agencies Healthcare organizations Industry Key Functions

6. Consortium Governance & Organization Governance Manual available at http://ctsaweb.org/Docs/CTSA_Governance_Manual.pdf http://ctsaweb.org/Docs/CTSA_Governance_Manual.pdf Governance for Cooperative Agreement

7. Consortium Governance & Organization Governance Manual available at http://ctsaweb.org/Docs/CTSA_Governance_Manual.pdf http://ctsaweb.org/Docs/CTSA_Governance_Manual.pdf CTSA Community Engagement Steering Committee Priorities  Develop evaluation outcomes and metrics for community engagement research  Share resources and instruments  Establish a registry of community-generated research ideas and needs assessment  Design educational curriculum

8. Consortium Governance & Organization Governance Manual available at http://ctsaweb.org/Docs/CTSA_Governance_Manual.pdf http://ctsaweb.org/Docs/CTSA_Governance_Manual.pdf CTSA Community Engagement Steering Committee Additional Priorities  Leverage partnerships for funding  Interact with other CTSA programs  Foster new research on the dissemination and implementation of relevant clinical & population-based research  Establish community based advisory boards

9. Consortium Governance & Organization Governance Manual available at http://ctsaweb.org/Docs/CTSA_Governance_Manual.pdf http://ctsaweb.org/Docs/CTSA_Governance_Manual.pdf CTSA Community Engagement Steering Committee Recent CTSA Community Engagement Activities: Established 2 topic-based workgroups: Regional Workshops Workgroup Community-Based Academic and Practice partnership Workgroup Education Workgroup Regional Workshops Jointly Sponsored by NCRR and APTR: “Kick-off” Workshop May 9 th in Bethesda, MD: “Accelerating the Dissemination and Translation of Clinical Research into Practice” Future workshops planned in 5 national regions

10. http://www.aptrweb.org/workshops/agenda.html

11. Community Engagement Milestones  Established Community Based Advisory Boards  Performed Community Engagement Needs Assessments  Established/Leveraged Partnerships for Funding  Developed Relevant trans-CTSA educational curriculum  Developed a Forum for Sharing Resources/Instruments

12. CTSAWeb.org

13. Community Engagement  Institutional Activities  National Activities  Membership  Meeting schedules and summaries http://www.ctsaweb.org/

15. CTSAWeb.org

16. NIH Transforming medicine and health through discovery