Presentation is loading. Please wait.

Presentation is loading. Please wait.

PRELAB 4 PHARMACEUTICS II By Mohamad Naseef. Prelab. 4 Preparations: 1)Peppermint water 2)Ca lactate 3)Suspension ----- Mist alba Problems: Conversions.

Similar presentations


Presentation on theme: "PRELAB 4 PHARMACEUTICS II By Mohamad Naseef. Prelab. 4 Preparations: 1)Peppermint water 2)Ca lactate 3)Suspension ----- Mist alba Problems: Conversions."— Presentation transcript:

1 PRELAB 4 PHARMACEUTICS II By Mohamad Naseef

2 Prelab. 4 Preparations: 1)Peppermint water 2)Ca lactate 3)Suspension Mist alba Problems: Conversions Conversions

3 Conversions Equivalents of length 1 M in. 1 in.2.54 cm. Equivalents of volume 1 ml m 1 m0.06 ml. 1 f ℨ 3.69 ml. 1 f ℥ ml 1 pt.473 ml 1 gal. (U.S.)3785 ml Equivalents of Weight 1 g gr. 1 k.g.2.2 lb. (avoir) 1 gr g. or 65 mg. 1 oz.(avoir)28.35g. 1 ℥ 31.1 g. 1 lb. (avoir)454 g. 1 lb. (apoth.)373.2 g. Other Equivalents 1 oz. (avoir.)437.5 gr. 1 ℥ 480 gr. 1 gal. (U.S.) 128 f ℥ 1 f ℥ (water) 455 gr. p.15

4 2) The dose of a drug is 1/10 gr. per kg. of body weight. How many milligrams should be given to a person weighing 154 lb.? 1 kg  2.2 lb ??  154 lb Wt of the person =1x154/2.2 = 70 kg 1/10 gr  1 kg ?? gr  70 kg The dose for this person = 70 x 1/10 =7 gr. 1 gr  65 mg 7 gr  ?? mg the required dose = 65 x 7 = 455 mg

5 AROMATIC WATERS Peppermint Water Rx Peppermint oil 0.2 ml Talc 1.5 g Water to 100 ml Peppermint Water Rx Peppermint oil 0.2 ml Talc 1.5 g Water to 100 ml The Peppermint Water [E.P.] Uses: carminative and flavoured vehicle

6 PEPPERMINT WATER Add Talc + 4 drops of oil and levigate Add 70 ml water Transfer to bottle Rinse with 30 ml Shake for 10 min Leave for 5 min Filter on filter paper Transfer to cup measure and adjust volume Rx Peppermint oil 0.2 ml Talc 1.5 g Water to 100 ml

7 The role of Talc: (1)Distributing agent  expose oil to solvent action of water due to large surface area. (2) Filter aid  adsorb excess oil.

8 CALCIUM LACTATE Rx Calci Lactatis Recentis Ʒi Syrup Auranti Ʒiii Aqua ad ℥ iii Fiat: Mistura Sig: Cochlearia magna duo bis in die sumenda Rx Calci Lactatis Recentis Ʒi Syrup Auranti Ʒiii Aqua ad ℥ iii Fiat: Mistura Sig: Cochlearia magna duo bis in die sumenda Ca lactate Orange syrup Water Ca lactate should be freshly prepared ? CaCO 3 + Lactic acid  Good solubility  No sour milk odor SOLUTION BY CHEMICAL REACTION used as source of Ca for children

9 CALCIUM LACTATE Rx Calci Lactatis Recentis Ʒi Syrup Auranti Ʒiii Aqua ad ℥ iii Fiat: Mistura Sig: Cochlearia magna duo bis in die sumenda Rx Calci Lactatis Recentis Ʒi Syrup Auranti Ʒiii Aqua ad ℥ iii Fiat: Mistura Sig: Cochlearia magna duo bis in die sumenda = 4 X 1 = 4 g = 3 X 4 = 12 ml = 3 X 30 = 90 ml Calculation: Ca lactate Orange syrup Water 2 X M.wt. 100 g ?? Lactic acid contains lactic acid 87.5% (w/w) + lactide (dimer of lactic acid) 87.5 g100 g g actualbottle ?? / ml 2 lactic acid + CaCO 3 = Ca lactate + CO 2 + H 2 O

10 CALCIUM LACTATE Rx Calci Lactatis Recentis Ʒi Syrup Auranti Ʒiii Aqua ad ℥ iii Fiat: Mistura Sig: Cochlearia magna duo bis in die sumenda Rx Calci Lactatis Recentis Ʒi Syrup Auranti Ʒiii Aqua ad ℥ iii Fiat: Mistura Sig: Cochlearia magna duo bis in die sumenda = 4 X 1 = 4 g = 3 X 4 = 12 ml = 3 X 30 = 90 ml 2 lactic acid + CaCO 3 = Ca lactate + CO 2 + H 2 O Calculation: Ca lactate Orange syrup Water 2 X M.wt. 100 g ?? = 32.4 g = 4o g xss

11 CALCIUM LACTATE Rx Calci Lactatis Recentis Ʒi Syrup Auranti Ʒiii Aqua ad ℥ iii Fiat: Mistura Sig: Cochlearia magna duo bis in die sumenda Rx Calci Lactatis Recentis Ʒi Syrup Auranti Ʒiii Aqua ad ℥ iii Fiat: Mistura Sig: Cochlearia magna duo bis in die sumenda = 4 X 1 = 4 g = 3 X 4 = 12 ml = 3 X 30 = 90 ml Lactic acid: 100 g Ca lactate  55.2 ml lactic acid 4 g  x Lactic acid = 4 X 55.2 / 100 = 2.2 ml CaCO 3 : 100 g Ca lactate  40 g CaCO 3 4 g  x CaCO 3 =40 X 4 / 100 = 1.6 g 100 g Ca lactate needs 40 g CaCO 3 and 55.2 ml lactic acid The Mixture One coffeecupful to be taken twice daily. Ca lactate Orange syrup Water 2 TABLESPOONFULS = 2 X 15 ml = 30 ml = One coffeecupful b.d.s. = twice daily

12 Preparation: In the flask: 2.2 ml lactic acid 1.6 g CaCO 3 60 ml water Boil for 15 minutes (3 precautions ) Filter on filter paper Transfer to cup measure cool Add syrup auranti Complete volume to 90 ml

13 CALCIUM LACTATE Lactide on storage hydrolysis  lactic acid which is of sour taste we must change all lactide to lactic acid then add CaCO 3  Ca Lactate by: 1 ) Diluting lactic acid with water 2) Boil for 15 min (heat break lactide to lactic acid). 3) Add excess CaCO3 (convert any lactic acid from lactide hydrolysis to Ca lactate) Storage effect (Commercial form have objectionable odor of sour milk:) 1) Lactide (hydrolysis)  lactic acid sour taste & bad odor. 2) Solubility decrease. Lactic acid contains lactic acid 87.5% (w/w) + lactide (dimer of lactic acid) 2 lactic acid + CaCO 3 = Ca lactate + CO 2 + H 2 O

14 SUSPENSIONS

15 Mist alba Rx Magnesium sulphate 5 g Light magnesium carbonate 1 g Peppermint water to 15 ml Fiat: Mist Sig.: 15 ml o.m. Factor = 4 X 4 20 g 4 g 60 ml Mitte: iv doses

16 Preparation: Grind MgSO 4 in mortar Add MgCO 3 in mortar Add peppermint water till pourable Continue volume with peppermint water Transfer to cup measure Rx Magnesium sulphate 5 g Light magnesium carbonate 1 g Peppermint water to 15 ml Fiat: Mist Sig.: 15 ml o.m. Use: Laxative and antacid in liver cirrhosis Rinse mortar with a LITTLE of peppermint water

17 The Mixture One tablespoonful to be taken every morning. Shake The Bottle

18 TAKE CARE!!!!!!!!!!!!  Light magnesium carbonate is self- diffusable & suspending so, NO need for suspending agent


Download ppt "PRELAB 4 PHARMACEUTICS II By Mohamad Naseef. Prelab. 4 Preparations: 1)Peppermint water 2)Ca lactate 3)Suspension ----- Mist alba Problems: Conversions."

Similar presentations


Ads by Google