Presentation on theme: "RABIES VIRUS. What ’ s this? Morphology and structure Replication Pathogenesis Clinical symptoms Diagnosis Prevention and Treatment."— Presentation transcript:
What ’ s this?
Morphology and structure Replication Pathogenesis Clinical symptoms Diagnosis Prevention and Treatment
Morphology bullet-shaped; 45-100 nm in diameter; 100-430 nm long.
structure Core -ssRNA L-protein (large protein) ---RNA dependent RNA polymerase RNP Capsid N-protein ---protect RNA from hydrolysis P-protein Envelope Bilipid layer M-protein (matrix protein) G-protein (glucoprotein) ---spike ---bind to the receptor of the host cell
Rabies is an RNA virus. The genome encodes 5 proteins designated as N, P, M, G, and L. The order and relative size of the genes in the genome are shown in the figure below. The arrangement of these proteins and the RNA genome determine the structure of the rabies virus.
Replication Adsorption Penetration Uncoating Biosynthesis Assembly and release
biosynthesis -ssRNA RNA polymerase +ssRNA -ssRNA protein virus