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Blood and Hematopoiesis Quiz. ResponseWare Login ResponseWare Web Web Address: Session ID: 752003 ResponseCard RF Channels: NA.

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Presentation on theme: "Blood and Hematopoiesis Quiz. ResponseWare Login ResponseWare Web Web Address: Session ID: 752003 ResponseCard RF Channels: NA."— Presentation transcript:

1 Blood and Hematopoiesis Quiz

2 ResponseWare Login ResponseWare Web Web Address: Session ID: ResponseCard RF Channels: NA ResponseWare App Not Enabled

3 1. Reticulocytes may be identified by light microscopy due to their containing basophilic remnants of A.Amino acids B.DNA C.Lipids D.RNA E.Sugars

4 2. As the last step in neutrophilic granulocytopoiesis, A.Antigen-stimulated monocytes differentiate into plasma cells B.Band cell nuclei will begin to become segmented C.Orthochromatophylic eryhtroblasts divide to form reticulocytes D.Monoblasts divide to form lymphocytes E.Eosinophilic granules are produced

5 3. Hereditary spherocytosis is a condition which involves a defect in a cytoskeletal protein of the erythrocyte, causing an abnormal spherical cell shape. This protein is A.Albumin B.Band 3 protein C.Hemoglobin D.Spectrin E.P-selectin

6 4. One function of the helper T lymphocytes is to stimulate B lymphocytes to undergo mitosis and subsequent differentiation into A.Antibodies B.Antigens C.Cytotoxic cells D.Natural killer cells E.Plasma cells

7 5. The predominant component(s) of blood plasma, making up roughly 90% of its weight is/are A.Albumin B.Neutrophils C.Protein D.Solutes E.Water

8 6. The predominant protein(s) in blood plasma is/are A.Albumins B.Fibrinogens C.Globulins D.Hemoglobin E.Red blood cells

9 7. The predominant cell type(s) in blood is/are A.Leukocytes B.Lymphocytes C.Neutrophils D.Platelets E.Red blood cells

10 8. The predominant leukocytic cell type in blood is/are A.Basophils B.Lymphocytes C.Monocytes D.Neutrophils E.T cells

11 9. The agranulocyte lineage of leukocytes contains the lymphocytes and what other cell type? A.Erythrocytes B.Macrophages C.Megakaryocytes D.Monocytes E.Neutrophils

12 10. Senescence of red blood cells is a process in which aged cells are destroyed by macrophages. The Band 3 protein involved in this process is actually a type of A.Chloride channel B.Cytoskeletal filament C.Platelet D.Stereocilia E.Tight junction

13 11. What is the most common human hemoglobin type? A.HbA B.HbA 2 C.HbF D.HbH E.HbS

14 12. Erythrocyte senesence ultimately leads to destruction by macrophages predominantly in which organ ? A.Liver B.Lymph nodes C.Spleen D.Thymus E.Yellow bone marrow

15 13. The typical lifespan of a circulating erythrocyte is A.1-2 hours B.2 days C.120 days D.2 weeks E.2 years

16 13. Of the 4 common, human blood types, Type O is unique in that an individual possesses red blood cells with no A or B antigens and A.Both A and B antibodies B.No A or B antibodies C.Only A antibodies D.Only B antibodies E.Only C antibodies

17 15. Neutrophils are motile cells. Microtubules play an important role in this locomotion ability along with A.Actin and myosin B.Large cell size C.Non-staining granules D.Prolonged lifespan E.Segmentation of their nuclei

18 16. Eosinophil specific granules stain eosinophilic giving the cell its characteristic red color. The predominant protein in the eosinophil specific granule is A.Collagen B.Collagenase C.Hemoglobin D.Keratin E.Major basic protein

19 17. Basophils are functionally similar to mast cells in that they secrete granules containing similar protein content, notably A.Antibodies B.Collagenase C.Heparin and Histamine D.Major basic protein E.P-selectin

20 18. Humoral immunity is mediated by B cells which upon activation by antigen recognition differentiate into a cell capable of producing antibodies, the A.B cell B.Macrophage C.Natural Killer cell D.Plasma cell E.T cell

21 19. Cell-mediated immunity is a function of many cells including T cells. A T cell which directly acts to kill cells expressing foreign antigens on their surface is termed A.Cytotoxic B.Helper C.Memory D.Natural E.Suppressor

22 20. Memory B cells derive from a naïve B cells initial exposure to a foreign antigen. What is true of the immune response of a memory B cell after a second exposure to that antigen? A.It doesn’t occur B.It involves the CNS C.It is larger in scope D.It is slower E.It is smaller

23 21. Platelets are cell fragments that derive from which cell type? A.Megakaryocytes B.Monocytes C.Osteocytes D.Plasma cells E.T lymphocytes

24 22. Platelets contain structures called granulomeres that contain numerous proteins. A key protein in the granulomere is a growth factor important in blood vessel growth and regeneration, and is named A.Leptin B.Major histocompatibility complex C.Platelet-derived growth factor D.P-selectin E.Perforin

25 23. Platelets possess contractile activity, and play an important role in repairs to blood vessels. This contractile activity in platelets is mediated in part by A.Actin and myosin B.Demarcation membranes C.Granulomeres D.Megakaryocytopoiesis E.Smooth muscle

26 24. Inactive marrow that functions primarily to store fat is termed A.Multilocular B.Red C.Unilocular D.White E.Yellow

27 25. Colony stimulating factors (CSFs) are compounds which influence hematopoiesis and promote the production of specific cell types. One key example, GM-CSF, when released, could lead to the increased production of which of the following cell types? A.B lymphocytes B.Basophils, eosinophils, neutrophils, monocytes C.Erythrocytes D.Megakaryocytes E.T lymphocytes

28 26. Hematopoietic growth factors direct the production of cell types in the bone marrow. Erythropoietin, a factor produced by the kidney increases the production of which cell type? A.B lymphocytes B.Basophils C.Erythrocytes D.Megakaryocytes E.T lymphocytes

29 27. Colony forming units (CFUs) are groups of cells which have committed to a common lineage in hematopoiesis. CFU-Ly defines cells which have committed to the lymphocyte lineage. Which common colony forming unit is responsible for the formation of granulocytes, monocytes, erythrocytes, and megakaryocytes? A.CFU-E B.CFU-GEMM C.CFU-GM D.CFU-Ly E.CFU-Meg

30 28. The bone marrow stroma is composed of adventitial cells which form a reticular network to support the marrow tissue and hematopoietic cell network. Hematopoietic cells bind to this network through a marrow-specific adhesion protein called A.Colony stimulating factor B.Hemonectin C.Heparin D.Lymphokine E.P-selectin

31 29. Examination of a normal peripheral blood smear reveals a cell more than twice the diameter of an erythrocyte with a kidney-shaped nucleus. These cells were <10% of total leukocytes. Which of the following cell types is being described? A.Basophil B.Eosinophil C.Lymphocyte D.Monocyte E.Neutrophil

32 30. Basophils, neutrophils, and eosinophils differentiate through a final common granulocytic precursor cell termed the A.Erythroblast B.Lymphoblast C.Platelet D.Promyelocyte E.Unilocular adipocyte

33 31. In the pathway of erythrocytopoiesis, the final defined precursor cell before the formation of a mature erythrocyte is called a :30 A.Erythroblast B.Myeloblast C.Platelet D.Reticulocyte E.T cell

34 32. The neutrophil is considered to ‘reside’ in several theoretical compartments during its development and lifespan. From its circulation in the bloodstream the neutrophil is able to migrate into connective tissue spaces upon binding a key endothelial cell adhesion molecule called :30 A.IgE antibody B.Collagenase C.Hemonectin D.Major binding protein E.P-selectin

35 33. When a blood vessel is damaged a coordinated sequence of events involving many cell types and proteins takes place. One of the initial steps is the aggregation of platelets to form a platelet plug at the site of the damage where collagen from connective tissue is exposed to the blood. The aggregation at this site is possible due to the platelets having :30 A.IgE antibody B.Collagenase C.Hemonectin D.Major binding protein E.Sticky glycoprotein coat

36 34. Identify this cell (arrow, black). :30 A.Basophil B.Eosinophil C.Lymphocyte D.Monocyte E.Neutrophil

37 35. Identify this cell (arrow, black). :30 A.Basophil B.Eosinophil C.Lymphocyte D.Monocyte E.Neutrophil

38 36. Identify this cell (arrow, black). :30 A.Basophil B.Eosinophil C.Lymphocyte D.Monocyte E.Neutrophil

39 37. Identify these structures (arrows, black). :30 A.Cellular debris B.Erythrocytes C.Platelets D.Processing artifact E.Reticulocytes

40 38. Identify this cell (arrow, black). :30 A.Basophil B.Eosinophil C.Lymphocyte D.Monocyte E.Neutrophil

41 39. Identify this cell (arrow, black). :30 A.Basophil B.Eosinophil C.Lymphocyte D.Monocyte E.Neutrophil

42 40. Identify this cell (arrow, black). :30 A.Basophil B.Eosinophil C.Lymphocyte D.Monocyte E.Neutrophil

43 41. Identify this cell (arrow, black). :30 A.Basophil B.Eosinophil C.Lymphocyte D.Monocyte E.Neutrophil

44 42. Identify this cell (arrow, black). :30 A.Basophil B.Eosinophil C.Lymphocyte D.Monocyte E.Neutrophil

45 43. Identify this cell (arrow, black). :30 A.Basophil B.Eosinophil C.Lymphocyte D.Monocyte E.Neutrophil

46 44. Identify this cell (arrow, black). :30 A.Basophil B.Eosinophil C.Lymphocyte D.Monocyte E.Neutrophil

47 45. Identify this cell (arrow, black). :30 A.B lymphocyte B.Eosinophil C.Megakaryocyte D.Monocyte E.Neutrophil

48 46. Identify this structure (arrow, black). :30 A.Eosinophil B.Lymphatic vessel C.Megakaryocyte D.Sinusoid E.T lymphocyte

49 47. Identify these cells (arrows, black). :30 A.Adipocytes B.Erythrocytes C.Lymphocytes D.Megakaryocytes E.Monocytes

50 48. Identify these cells (arrows, black). :30 A.B lymphocytes B.Eosinophils C.Megakaryocytes D.Monocytes E.Neutrophils

51 49. Identify these structures (arrows, black). :30 A.Eosinophils B.Lymphatic vessels C.Megakaryocytes D.Sinusoids E.Woven bone

52 50. In this image of a bone marrow smear, the indicated cells belong to which hematopoietic lineage (arrows, black)? :30 A.B lymphocyte B.Erythroid C.Lymphoid D.Monocytic E.Myeloid

53 51. Your patient is suffering from an infestation of parasites. To determine the proper therapy, you perform an analysis of a peripheral blood sample. Which of the following cells would you expect to be increased in a peripheral blood smear? :30 A.Basophils B.Eosinophils C.Lymphocytes D.Monocytes E.Neutrophils

54 52. A decrease in the number of tissue macrophages would result from reduced activity of precursor cells to which of the following cell types? :30 A.Basophils B.Erythrocytes C.Monocytes D.Neutrophils E.Megakaryocytes

55 53. Which of the following cells is the primary phagocytic cell within peripheral blood? :30 A.Basophil B.Eosinophil C.Lymphocyte D.Monocyte E.Neutrophil

56 54. Pernicious anemia develops as a consequence of which of the following? :30 A.Amino acid change of the globin moecule B.Decreased levels of intrinsic factor C.Decreased iron D.Decreased platelets E.Decreased synthesis of hemoglobins

57 55. While examining a peripheral blood smear, you notice an increased number of cells slightly larger than an erythrocyte. These cells have a large, round nucleus and scant cytoplasm. Which of the following would cause this condition? :30 A.Bacterial infection B.Hemorrhage C.Organ transplant rejection D.Parasitic infection E.Pollen infestation

58 56. A young man complains that he bruises easily. A laboratory report showed a normal white cell count. Erythrocytes were 5 million/mm 3, whereas platelets were 50,000/mm 3. Which of the following was the diagnosis? :30 A.Hemophilia B.Pernicious anemia C.Polycytothemia D.Thalassemia E.Thrombocytopenia

59 57. Which of the following blood cells differentiate outside of the bone marrow? :30 A.Basophils B.Eosinophils C.Megakaryocytes D.Neutrophils E.T lymphocytes

60 58. An analysis of a peripheral blood smear showed that reticulocytes were 10% of total cells. Which of the following represents the proper diagnosis? :30 A.Cell-mediated immune response B.Hemorrhage C.Humoral-mediated immune response D.Infection E.Myelocytic leukemia

61 59. Which of the following is not derived by a mitotic division of a precursor cell? :30 A.Monocyte B.Osteoblast C.Polychromatophilic erythroblast D.Platelet E.Proerythroblast

62 60. Examining a peripheral blood smear, you note a cell type that consists of both large and small cells intermixed with normal size cells, a condition described as anisocytosis. This abnormal condition refers to which of the following? :30 A.Basophils B.Erythrocytes C.Lymphocytes D.Monocytes E.Platelets

63 61. Your patient suffers from a blood disorder that requires chemotherapy. A bone marrow transplant is subsequently performed. Transplants containing which of the following cells in the erythrocytic series would not provide proliferative cells? :30 A.Basophilic erythroblast B.Hematopoietic stem cell C.Orthochromatophilic erythroblast D.Polychromatophilic erythroblast E.Proerythroblast

64 62. At which of the following stages are specific cells of the granulocytic series first recognizable? :30 A.Hematopoietic stem cell B.Metamyelocyte C.Myeloblast D.Myelocyte E.Promyelocyte

65 63. Hemoglobin is first seen in which of the following cells of the erythrocytic series? :30 A.Basophilic erythroblast B.Orthochromatophilic erythroblast C.Polychromatophilic erythroblast D.Proerythroblast E.Reticulocyte

66 64. In which of the following cells of the erythrocytic series is the nucleus extruded? :30 A.Basophilic erythroblast B.Orthochromatophilic erythroblast C.Polychromatophilic erythroblast D.Proerythroblast E.Reticulocyte

67 65. While examining cells of a bone marrow smear with the light microscope, you notice a cell whose cytoplasm has no noticeable granules. The nucleus of this cell in indented and contains no nucleoli. Which of the following cells are you examining? :30 A.Basophilic erythroblast B.Myelocyte C.Neutrophilic metamyelocyte D.Polychromatophilic erythroblast E.Promyelocyte

68 66. Which of the following best characterizes bone marrow? :30 A.All blood cells undergo maturation within the bone marrow B.Destruction of erythrocytes is carried out in red bone marrow C.Lymphocytes mature in bone marrow D.Monocytes mature in bone marrow E.Yellow bone marrow does not function to produce blood cells

69 67. A sample of peripheral blood from a patient reveals a larger than normal population of cells that have large, round nuclei with 1 or 2 nucleoli. The cytoplasm of these cells shows azurophilic granules. Which of the following forms of leukemia would you suspect? :30 A.Basophilic leukemia B.Eosinophilic leukemia C.Lymphoblastic leukemia D.Promyelocytic leukemia E.Stem cell leukemia

70 68. A peripheral blood smear of a person suffering from a mild form of leukemia showed a large number of cells with more than 1 nucleolus. Which of the following cells is being described? :30 A.Myeloblast B.Neutrophilic metamyelocyte C.Neutrophilic myelocyte D.Orthochromatophilic erythroblast E.Polychromatophilic erythroblast

71 69. Your patient suffers from lymphocytic leukemia. Chemotherapy is administered to destroy cancerous cells of the bone marrow. Precursor cells to erythrocytes are destroyed. To specifically re-establish the erythrocytic cell line, which of the following cells should be transplanted? :30 A.Basophilic erythroblasts B.Megakaryoblasts C.Metamyelocytes D.Orthochromatophilic erythroblasts E.Reticulocytes

72 70. As cells undergo the process of erythropoiesis, which of the following occurs? :30 A.Chromatin becomes more diffuse B.Nuclei become lobulated C.Nuclei decrease in size D.Nucleoli increase in number E.Rough endoplasmic reticulum increases within the cytoplasm


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