1. Department of Life Sciences  Biological Sciences –Botany, Zoology, Marine Biology, Microbiology, Biochemistry, Molecular and Cell Biology, etc.  Agricultural Sciences –Agronomy, Horticulture, Forestry, Fishery, Animal Husbandry, Veterinary Science, Agricultural Chemistry, Food Science, etc.  Medical Sciences –Basic Medical Sciences: Anatomy, Physiology, Pharmacology, Biochemistry, Microbiology and Immunology, Molecular Medicine, Epidemiology, Public Health and Occupational Medicine, Legal Medicine and Forensic Science, etc. –Clinical Sciences: Internal Medicine, Surgery, Radiology, Nuclear Medicine, Gynecology and Obstetrics, Pediatrics, Dentistry, etc.  National Science and Technology Programs –Agricultural Biotechnology, –Genomics Medicine, –Pharmaceutical Biotechnology.

2. 1996-2005 Annual Budget, Dept. of Life Sciences (Thousand USD)

3. Life Sciences Grant Applications and Funding

4. Department of Life Sciences Funding Policy  Individual Grant  Program Project  Frontier Science Program  Team of Excellence Program  Inter-ministerial Health Food R & D Program  Inter-disciplinary Integration Program  International(Bilateral) Collaboration Program  Industrial-University Collaboration R & D Program  Biotechnology Successful Investment Program  National Science and Technology Research Program Genomic Medicine S & T Research Program Biotechnology Pharmaceuticals S & T Research Program Agriculture Biotechnology S & T Research Program

5. Bioengineering Program Project  To focus on research fields with integrated efforts of inter-departments, inter-institutes, and inter- universities.  To promote international collaboration Major research areas: 1.Functional tissue/molecular imaging 2.Mobile monitoring and distributing wireless integrated sensors system 3.Biomedical optics and biophotonic monitoring systems 4.New biomechanics of tissues, cells, and genes 5.Tissue and cell engineering and new biomaterials

6. Bioinformatics Multidisciplinary Research Programs  Genome annotation and development of its tools  Microarray and proteomic data analysis and value-added data bank  Macromolecular sequencing and structural data analysis  Phylogenetic data analysis

7. Industry-University Cooperative Research Program To promote advanced and applied technology research by the academic community, and also to encourage enterprises to actively participate in applied academic research, and thereby to enhance the R&D capabilities and skilled manpower of private sectors.

8. The Budget for the National Science and Technology Program million USD NSTPAB ： National Science and Technology Program for Agricultural Biotechnology NSTPBP ： National Science and Technology Program for Biotechnology and Pharmaceuticals NRPGM ： Nation Research Program for Genomic Medicine SARS ： SARS Research Project

9. Agricultural Biotechnology National Program Fifteen Research Teams  Development and integration of floral (Chrysanthemum and orchids) production and marketing systems.  Integration and industrial application of conventional and genetic- engineered post-harvest technology for vegetables and fruits.  Integration of key techniques for organic farming (e.g. stress tolerant varieties, bioprotectants and biofertilizers).  Promotion and establishment of production systems for high quality Chinese herbs and health foods.  Development of fry production systems with quality assurance (shrimp and grouper) and related transportation and marketing technology.  Biotechnology applications in the production of Taiwan tilapia for international market.  Application of biotechnology in the improvement of cage-culture and processing technology for Cobia.

10. Agricultural Biotechnology National Program Fifteen Research Teams  Agricultural waste treatments in generating value-added by- products.  Inventing and improving production systems for high quality swine and chicken.  Developing biological agents (vaccines and adjuvants) for plant- and animal-related applications.  Application of transgenic technology for ornamental plants and fishes, and for medical and feed industries.  Development of molecular techniques for diagnostic systems and marker-assisted breeding.  Development of bioreactor technologies for producing industrial and medical materials.  Establishment of GMO assessment and accrediting systems.  Research and development of novel functional genomics based technologies for biotechnological industries.

11. D.C.N. Chang

12. SWEET RICE transgenic rice seeds expressing an amylopullulanase (APU) gene S.M. Yu and J.F. Shaw

13. National Program in Biotechnology and Pharmaceuticals (1999-2006) Natural Products Synthetic Chemicals Protein Drugs Protein Chips Drug Screening and Evalulation Clinical Trials Industrial Applications and Technology Transfer

14. R&D on YC-1 and its Derivatives Project Academics ： China Medical University （ Sheng-Chu Kuo ）， National Taiwan University College of Medicine （ Che-Ming Teng ） Enterprise ： Health BioX Biotech. Co. （ Fang-Yu Lee ） Niche ： PCT patents with multi-indications, over 170 international SCI papers acknowledgements Challenge ： Compete with other pharmaceutical companies such as Aventis and Bayer etc. Targets ： 1. YC-1 clinical trial (US and Taiwan) 2. R&D on follow-up YC-1 derivatives 3. Establishment of a R&D Center

15. Project for Development of Microfluidic Biochip Systems Academy ： National Cheng Kung University （ Gwo-Bin Lee, Shu-Hui Chen, Jiunn-Jong Wu, Ching-Hsing Luo, Mei-Ling Tsai, Jyh-Ming Ting, Chih-Ching Chang ） Enterprise ： President Biosystem Inc. Niche ： 7 patents (10 in patent application process) Challenge ： Competition with overseas companies Targets ： 1. Develop a series of advanced biochip systems 2. Development of biochips for early detection of virus/bacteria – related diseases. The developed microfluidic biochip systems have successfully demonstrated their capability for fast diagnosis of virus/bacteria-related diseases. This project will collaborate several local companies to start up a competitive bio- MEMS company. 可攜式細胞前處理及 PCR 模組 PCR 溫度控制元件照片 Portable apparatus for cell pretreatment and PCR chips.

16. National Science and Technology Program on Genomic Medicine (2002 - 2009) CANCER LIVER LUNG ELSI INFECTIOUS DISEASES HIGHLY HERITABLE DISEASES INNOVATIVE RESEARCH Industrial Cooperation Interanational Cooperation

17. Core facilities The National Program attempts to coordinate national resources and to fund projects that are in line with Taiwan’s strategic development. Comprehensive cores have been established to support various scientific programs. Six major core facilities: Mutant Mouse Facility and Disease Models Clinical Tissues Bank High Throughput Genomics Facilities Proteomics and Structural Biology Facilities Bioinformatics Innovation and Key Technology Development

18. Result in Lung Cancer 1.Many tumor suppressor genes (TSGs) had 5’CpG hypermethylation in their promoter and/or exon1 regions in lung cancer. 2. These TSGs are: hMLH1 and hMSH2, p16INK4a), p14ARF, FHIT, BLU, RASSF1A, RARβ, HIF, SLIT2, BRCA1/2. 3. Overexpression of DNA methyltransfer enzymes (DNMTs) contributes to NSCLC tumorigenesis and associate with 5’CpG hypermethylation in their target TSGs. The mRNA and protein of DNMTs were highly expressed in tumor tissue.

19. ENU mutagenesis established mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. (J. Clin. Invest. 2004) ENU mutagenesis mouse models of human metabolic disease