1. Senate Education Committee Briefing Russell Ingram, Executive Director March 23, 2011

2. MRC—why now? “Science and medicine are at one of those inflection points that you get every so often, giving rise to very significant opportunities.” Professor Sir John Bell

3. “New Science” opportunities  Computational life science: advanced computing to solve complex life science problems  Genomics: studies a person’s entire DNA sequence  Population health: systems approach to genomic, environmental, and behavioral determinants of health  Regenerative medicine: synthetic tissues and cells, laboratory-made compounds, and artificial organs

4. The MRC plan  Build on existing “New Science”  Leverage the excellence of private institutions  Develop the strengths of the State’s universities  Promote productive inter-institutional collaborations  Increase revenue and output  Promote aggressive tech transfer and commercialization

5. The MRC goals  Perform great science  Grow annual research spending past $1B  $300m increase from current level  Build new blockbuster ventures  Educate next generation of professionals

6. A strong foundation for growth

7. Building on strengths  Around $100M new computational science and genomics investments at St. Jude  Existing “New Science” assets at UTHSC and UoM  Clinical research and genomics at the new, $350M Lebonheur Children’s Hospital  Clinical healthcare and clinical research  The Memphis medical device industry  Fedex focus on biologistics

8. Building on strengths  UTHSC  Center for Integrated Translational Genomics  Tennessee Mouse Genome Consortium: experimental genomics resource used worldwide  Clinical translational science programs  Molecular Resource Center  University of Memphis  School of Public Health  Innovative bioinformatics program  Major funded efforts in disease intervention  Comprehensive science resources  Joint UM/UTHSC biomedical engineering program  Offers graduate degrees in the fastest growing engineering field in the country  Joint MCAN 10GB fiber optic network  Robust VC, startup, and incubator community

9. Proposed state investment  Total FY 2011-2012: $10M  $6M: Computational science for genomics and population health to fight pediatric obesity and diabetes Startup funds for 5-7 senior, funded scientists Includes needed infrastructure  $4M: Materials science and tissue engineering for regenerative medicine Startup funds for 2-3 senior, funded scientists Includes needed infrastructure

10. Use of FY 2011 startup funds  Total FY 2010-2011: $500k

11. Repeat TN’s UTK/ORNL success UTK/ORNL’s 2002 position is comparable to Memphis in 2010. With help, Memphis will grow as aggressively as UTK/ORNL.

12. Expected economic impact  Create prosperity 1  5,800 new jobs 2011-2020  $257 million in new direct wages 2011-2020  $17 billion in new business activity impact 2  Fight pediatric obesity and diabetes at ground zero  Tennessee’s burden of diabetes in 2006 was $3 billion  Memphis burden of diabetes in 2006 was $420 million  Memphis research will design meaningful interventions 1. Projections based on US Dept of Commerce RIMS II data 2. Business activity returns over a 10-15 year period.

13. Memphis research delivers... …a source of pride for Tennessee …a growing bioscience workforce …a new generation of enterprise …new treatments and cures …reduced burden of chronic disease Memphis research is paying off for Tennessee.