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CHEE 450 March 30, 2009 Jeff DeMeza Blair Walker Richard Wong.

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Presentation on theme: "CHEE 450 March 30, 2009 Jeff DeMeza Blair Walker Richard Wong."— Presentation transcript:

1 CHEE 450 March 30, 2009 Jeff DeMeza Blair Walker Richard Wong

2  Removes particulates larger than a specified pore size from filtrate  Particulates accumulate as a filter cake  Batch operation  Flow properties change with time › Filtrate flux › Pressure drop

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4  Removes residual IBs, cell debris & biomass  Specifications › 1.25 hours filtration time, 23.3 kg filter cake/batch

5 3mm + 100% Safety Factor aste Permeate Filter A filter surface = 13.8 m 2

6  Through Put  Pressure  Disposable

7  Combined sterile filter and casing design  Dispose after each batch  Most expensive filter  Validation requirements are met  Low capital costs

8  Disposable filter  Reusable Stainless steel casing  No contact of filtrate with casing  Casing does not need to be cleaned between batches  Initial validation required  Large initial capital cost of casing

9 Steel Casing and Disposable Filter Disposable Filter and Casing Capital Cost$50 000~$0 Cost of filter per batch $2 500$3 900 Total cost for year 1 $ $

10 Note: does not include validation costs

11  Produced by Pall > ~ $2500 / batch > Area surface = 14m 2 > P = 3.5 bar > Pore size = 0.2  Quattro Flow pump manufactured by Triangle Process Equipment

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