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Eugenio Dr.Vincenzi Technical Manager Sintofarm. SintoMANN is a prebiotic rich in mannanoligosaccharides (MOS), produced from the cell wall of a specially.

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Presentation on theme: "Eugenio Dr.Vincenzi Technical Manager Sintofarm. SintoMANN is a prebiotic rich in mannanoligosaccharides (MOS), produced from the cell wall of a specially."— Presentation transcript:

1 Eugenio Dr.Vincenzi Technical Manager Sintofarm

2 SintoMANN is a prebiotic rich in mannanoligosaccharides (MOS), produced from the cell wall of a specially selected strain of Saccharomyces cerevisiae. Highly efficient in the agglutination of pathogens, reducing risk of pathogen colonization of gut. Modulates gut flora, with reduction of gut disorder episodes and negative impact on animals. Eugenio Dr.Vincenzi Sintofarm spa

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4 Competition Products – A Few Results Innactive Dry Yeast – Solubles due to wall rupture caused by fast water evaporation Hydrolysis – High solubles, added minerals (clay), loss of mannans Partial ‘Lysis’ – Low protein suggests separation of extracts to some extent, but still too much solubles Eugenio Dr.Vincenzi Sintofarm spa

5 Furlan e Berchieri Jr., 2008 Average (log 10) of counts of SALMO in cecal content of broilers (3 and 6 days after infection) Eugenio Dr.Vincenzi Sintofarm spa

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7 E.coli pili attaches to SintoMANN Yeast Cell Wall E.coli pili Yeast Cell Wall E.coli Layered Cell Wall Structure Eugenio Dr.Vincenzi Sintofarm spa

8 SintoMANN agglutinates isolated strains of Vibrio ordalii and atypical Aeromonas salmonicida ¹ Bacteria were cultivated in Luria agar and TSA agar (Tripticase Soy agar). ² After incubation, 2 bacterial suspensions were produced: 0.25 (7.5X10 7 ) and 0.50 McFarland scale (1.5X10 8 bacteria/ml). Negative(-): absence of agglutination reaction. Mild reaction (+): focal agglutination reaction Moderate reaction (++): diffuse agglutination reaction. Don´t produce type 1 fimbriae Eugenio Dr.Vincenzi Sintofarm spa

9 SintoMANN works in the pathogen agglutination. Experimental Trial in vitro (Santurio, J. M.; Alves, S. M Universidade Federal de Santa Maria). SintoMANN agglutinated pathogens GRAM - Eugenio Dr.Vincenzi Sintofarm spa

10 SintoMANN acts on the reduction of Clostridium perfringens. 8% Lower Mortality Positive Synergy with Antibiotic GRAM+ Experimental trial carried out with broilers challenged with Clostridium perfringens, added SintoMANN (1,5 kg/ton). (Mathis, G.F. et al Southern Poultry Research, Inc. Athens, GA). Eugenio Dr.Vincenzi Sintofarm spa

11 14% Better Feed Conversion LSD Test (P<0,05) Eugenio Dr.Vincenzi Sintofarm spa

12 18% Higher Weight Gain LSD Test (P<0,05) Eugenio Dr.Vincenzi Sintofarm spa

13 SintoMANN acts promotes intestinal health SintoMANN increased the number of Bifidobacteria. Experimental trial carried out with broilers, with dietary inclusion of SintoMANN in the starter and grower diets(1.5 and 1.0 kg/ton, respectively). (Bushansingh, B.; Zhao, X McGill University, Montreal, Canada). Eugenio Dr.Vincenzi Sintofarm spa

14 1 SEM (Standard Error of the Mean): Mean ± SEM of 9 replicates). Test of Scheffe (P>0.05) SintoMANN improved the integrity of the intestinal mucosa. Eugenio Dr.Vincenzi Sintofarm spa

15 SintoMANN allows the withdrawal of antibiotic growth promoter Tukey Test (P<0,05) Experimental trial carried out with broilers, with dietary inlcusion of SintoMANN in pre-starter / starter, grower and finisher diets (1.5, 1.0 and 0.5 kg/ton, respectively).. Eugenio Dr.Vincenzi Sintofarm spa

16 Tukey Test (P<0,05) SintoMANN was better than competitors in jejunum villi height and weight gain. Eugenio Dr.Vincenzi Sintofarm spa

17 SintoMANN improves performance Duncan Test (P<0,05) Experimental trial carried out with broilers, with dietary inclusion of SintoMANN in pre starter/starter, grower, and finisher diets, (1.5; 1.0 and 0.5 kg/ton, respectively). Eugenio Dr.Vincenzi Sintofarm spa

18 SintoMANN promoted: Weight Gain Better Feed Conversion Duncan Test (P<0,05) Eugenio Dr.Vincenzi Sintofarm spa

19 Assessment of SintoMANN additioned to broiler diets Improves on average the production by 3.3%. Eugenio Dr.Vincenzi Sintofarm spa

20 SintoMANN promotes weight gain in piglets 18% Higher Weight Gain 14% Better Feed Conversion 10% Higher Body Weight Eugenio Dr.Vincenzi Sintofarm spa

21 SintoMANN controls the incidence of diarrhea of newly – weaned piglets Fecal score of piglets fed different levels of a prebiotic, source of mannanoligosaccharides (SintoMANN) - 23,3% of diarrhea with 1kg/MT of SintoMANN - 47,5% of diarrhea with 2kg/MT of SintoMANN Eugenio Dr.Vincenzi Sintofarm spa

22 SintoMANN increases the production of acetic acid and propionic in dogs Short-chain fatty acids, derived from the metabolism / differential fermentation of certain sugars, are favorable for increasing the production of energy available for the maintenance of intestinal integrity. SintoMANN increased the concentration of butyric acid, linear and showed superior effect on the production of acetic acid and propionic. Eugenio Dr.Vincenzi Sintofarm spa

23 SintoMANN promotes reduction of tyramine and histamine in feces of dogs SintoMANN promoted linear reduction in the concentrations of tyramine and histamine in feces and resulted in responses in the fecal production of phenyl ethylamine. Eugenio Dr.Vincenzi Sintofarm spa

24 SintoMANN promotes adherence of E.coli Eugenio Dr.Vincenzi Sintofarm spa

25 SintoMANN is higher in agglutination of bacteria E. coli. SintoMANN promotes adherence of E.coli Eugenio Dr.Vincenzi Sintofarm spa


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