1. AGRAZINC 100

2. WHAT IS AGRAZINC 100
AGRAZINC 100 is a concentrated for of micro-encapsulated ZINC OXIDE
For a more effective release int the gastrointestinal tract of animals.
For treatment against DIARREAH.

3. MODE OF ACTION
The lipid coating in AGRAZINC 100 is disolved by hy lipase enzyme when it reached the duodenum and ZINC OXIDE is slow released into the area for immediate action.
The micro-encapsulation prevents the AGRAZINC 100 from being adosorbed or changed before it gets to the duodenum.
The micro-encapsulation PREVENTS the natural negative effect on palatibility by ZINC OXIDE.

4. AGRAZINC 100: Effects on post weaned piglets 1
Design
90 hds at avg. 24 days, 3 hds per pen(30 pens)
Place and Period: Florida (US), for 28 days (OCT, 2006)

5. AGRAZINC 100: Effects on post weaned piglets 1
Diet design(normal)
1-12 days : CP 22%, Total lysine 1.6%
13-28 days : CP 18%, Total lysine 1.25%
* all diets are included with 100ppm ZnSO4
Treatments
Control: normal diet+ZnO, 150ppm Zn
Treated 1(T1): normal diet+ ZnO, 3000ppm Zn
Treated 2(T2): normal diet+ AGRAZINC 100, 200g/T

6. AGRAZINC 100: Effects on post weaned piglets 1
0.462
0.457
0.345
P<0.05
[United States, 2006]

7. AGRAZINC 100: Effects on post weaned piglets 1
0.7
0.694
0.578
P<0.05
[United States, 2006]

8. AGRAZINC 100: Effects on post weaned piglets 1
0.67
0.65
0.6
P<0.05
[United States, 2006]

9. AGRAZINC 100: Effects on post weaned piglets 1
13.4 %
3.7%
3.2%
P<0.05
[United States, 2006]

10. AGRAZINC 100: Effects on post weaned piglets 2
Design
Post weaned piglets 90 hds at avg. 20 days, 5 hds/pen(18pens), 3 replications
Place and Period: Florida (US), 28 days (DEC, 2006)
Diets design (normal) and materials
1-8 days: 1.5% total lysine
9-28 days: 1.3% total lysine
ZnO: Zn 72%
Antibacterial agent: Carbadox 55mg/kg

11. AGRAZINC 100: Effects on post weaned piglets 2
Treatments
control: normal diet
Treated 1(T1): control+ AGZ 200g/T
T2: control+ ZnO 3000ppm
T3: control+ Carbadox 55mg/kg
T4: T3+ AGZ 200g/T
T5: T4+ ZnO 3000ppm

12. AGRAZINC 100: Effects on post weaned piglets 2
Daily Gain, g
P<0.05
Carbadox 55mg/kg, No Carbadox
[United States, 2006]

13. AGRAZINC 100: Effects on post weaned piglets 2
Daily Feed Intake, g
P<0.05
Carbadox 55mg/kg, No Carbadox
[United States, 2006]

14. AGRAZINC 100: Effects on post weaned piglets 2
AGRAZINC 100 give ‘synergy effect’ to producers when it was used with AGPs
AGRAZINC g/t can replace the effect of ZnO at 3000 ppm, effectively.

15. AGRAZINC 100: Effects on post weaned piglets 3
Place and Period
National Swine Reaserch and Training Center(Thailand), 35 days
Design
Post weaned piglets 32 hds at 35 days, 8 hds/pen(4pens)
Infected 10 ml of 107cfu of E. coli and 10 ml of 107 cfu of haemolytic E. coli(K88) in every pig in the 3th days after weaning and keep the data same parameter
Antibiotics(Colistin 100ppm)

16. AGRAZINC 100: Effects on post weaned piglets 3

17. AGRAZINC 100: Effects on post weaned piglets 3

18. AGRAZINC 100: Effects on post weaned piglets 3
AGRAZINC 100 treatment had better performance, even in case of haemolytic E. coli(K88) infection.
AGRAZINC 100 show ‘synergy effects’ when it was used with antibiotics.
AGRAZINC 100 is the effective alternative for pharmacological level of ZnO in animal diets

19. AGRAZINC 100: Effects of ZnO sources on piglet’s performance(2007
AGRAZINC 100: Effects of ZnO sources on piglet’s performance(2007. April)
Trial design and Place
6 weeks old piglets weaned at 35 days, 60 heads.
20 heads/group, 3 test groups.
24 days trail
Dr. Wang, Ji-Hui(Prof.), Dalian Polytechnic Univ.(China)
Trial diets design
Control: normal diet spec. + ZnO 3000ppm
T1: normal diet spec. + Agrazinc 300ppm
T2: normal diet spec. +Agrazinc 100ppm
* Effects of pharmaceutical dosage of ZnO is well known, so we have conducted this trial without ‘negative control without 3000ppm’ intentionally.
Diet : Corn-soy based diet

20. Measuring Items Feed Intakes Average Daily Gain(ADG) FCR
Diarrhea rate(%)
Metabolism value, %
pH profile in digestive tract
Microorganism profile in digestive tract

21. Avg. Daily Feed Intake(ADFI)
0.897±0.162
0.816±0.333
0.730±0.074
ADFI, kg

22. Avg. Daily Gain(ADG)
0.483±0.050
0.459±0.109
0.318±0.166
ADG, kg

23. FCR
2.753±0.468
1.978±0.169
1.512±0.022

24. Diarrhea rate (%)
3.45±3.28
2.11±2.40
Diarrhea rate, %
1.48±1.92

25. Dry Matter(DM) Metabolism value, %
88.09±0.86
86.90±1.44
DM metabolism , %
81.95±1.76

26. Metabolism value, % Metabolism value, % 85.42 83.01 76.34 74.39 65.23
64.02
61.77
50.19
48.53
Metabolism value, %

27. pH profile in digestive tract
7.70
7.29
7.11
7.08
7.06
6.88
6.28
6.19
pH value
6.17
6.15
6.18
6.07

28. Microorganism profile in digestive tract: E. coli, log10
7.14
6.73
6.40
6.26
6.20
5.66
5.56
5.52
5.42
5.44
5.28
E. coli, log10
4.74

29. Microorganism profile in digestive tract: Lactobacillus acid., log10
8.89
8.88
8.81
7.82
7.69
8.66
7.76
7.66
7.35
7.20
Lactobacillus acid., log10
6.51
6.14

30. Bifidobacterium bif. , log10
Microorganism profile in digestive tract: Bifidobacterium bifidum, log10
9.80
9.62
9.49
9.39
9.40
9.24
9.23
9.07
8.12
8.03
Bifidobacterium bif. , log10
7.59
7.10

31. Summary
AGRAZINC 100…
It showed superior beneficial effects in growth, digestion, diarrhea and microorganism in the gut of piglet in comparison with normal pharmaceutical dosage of ZnO. It means we can reduce inclusion level of ZnO in animal diets with sustainable performances..
..and avoid environmental pollution. In addition, AGRAZINC 100 also showed a good performance in micro organism control in the gut; reduction in E. coli. It may replace AGPs in diets successfully.

32. AGRAZINC 100: benefits Treat and prevent Diarrhea
Minimize the excretion of Zn: prevent environmental pollution
Better Feed Intake
Alternative for AGPs
ADG & FCR improvement
Reduce pH in the gut
Increase the activity of beneficial micro organism
Reduction in pathogen; E. coli etc.

33. AGRAZINC 100 INCLUSION RATES:
PIGLETS and CALVES: 200 gr/MT of feed (if they encounter severe case, 300 gr/MT are recommened)
SWINES,LAYERS AND BROILERS:
100 gr / MT of feed
DAIRY AND BEEF CATTLE: 4 GRAMS/HEAD PER DAY
HORSES: 2 GRAMS / HEAD PER DAY
SHEEP: 2 GRAMS PER HEAD PER DAY.