1. Section 3 Thrombosis Definition: Thrombosis is the formation of a blood clot within the vascular system during life. The blood clot is adherent to the vessel wall.

2. Etiology and Pathogenesis (1) Endothelial injury: ① Causes: atherosclerosis (probably the single most important cause), myocardial infarction, cardiac surgery, inflammatory or immunologic injuries to the heart valves or blood vessels.

3. Etiology and Pathogenesis (1) Endothelial injury: ② Mechanisms: a. Adhesion of platelets to exposed collagen at the site of endothelial damage. b. Secretion of adenosine diphosphate (ADP) and thromboxane A2 by the adherent platelets. c. ADP and thromboxane induce platelet aggregation d. Activation of blood coagulation by: (i) The intrinsic pathway, initiated by collagen activation of Factor Ⅻ (ii) The extrinsic coagulation pathway, initiated by tissue factor, derived from damaged endothelium

4. Slide 5.5 (from Robbins Basic Pathology,2003, a litter be changed)

5. Slide 5.6 (from Robbins Basic Pathology,2003, a litter be changed)

6. Slide 5.7 ( from Robbins Basic Pathology,2003, a litter be changed)

7. Slide 5.8 (from Robbins Basic Pathology,2003, a litter be changed)

8. Slide 5.11

9. Etiology and Pathogenesis (2) Changes in blood flow: ① Stasis ② Disruption of laminar flow.

10. Etiology and Pathogenesis (3) Changes in the constitution of the blood: Hypercoagulability ① Following major surgery or trauma ② In pregnancy and parturition ③ In some users of the oral contraceptive pill ④ After splenectomy ⑤ In endotoxic shock, hypersensitivity reactions. ⑥ In association with some tumors.

11. Photo is offered by Prof. Orr

12. Steps in the formation of a thrombus 参照武忠弼 病理学规划教材第一版 人民卫生出版社修改

13. Morphological types of thrombi (1) pale thrombus Constitution: alternating layers of platelet Location: arteria, cardiac valves and the initiative part of venous thrombus

15. (2) red thrombus Constitution: coagulated red blood cells Location: at the end part of venous thrombus

16. (3) mixed thrombus Constitution: fibrin with meshed red blood cells between platelet layers Location: at the middle part of venous thrombus,ball thrombus in cardiac atrium

18. (4) Fibrin thrombus( Microthrombus) Constitution: fibrin Location: microcirculatin in DIC

20. Consequences of thrombosis: (1) Resolution: (2) Organization and re-canalization. (3) Detachment: thromboembolism (4) Calcification: intravascular "stones" are formed.

21. Marked passive congestion of the left lower leg in a patient with a deep venous thrombus Surgical dissection of the thrombus. (Photos are offered by Prof. Orr)