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Fluid and Hemodynamic Disorders
Where’s my water? Intracellular IonsIon specific gates in cell membrane Cellular proteins Extracellular Interstitial (between the cells) Lymph Intravascular Blood Lymphatic fluid
Movement of water in the vascular systemHydrostatic, the pumping pressure Heart Skeletal muscle action Oncotic or osmotic, holds fluid in. Proteins such as albumin Cellular elements such as RBCs
Intracellular & Extracellular Water
Things can go wrong Heart failure Kidney failure Myocardial infarctionPulmonary emobolus Tissue congestion Edema
Edema Too much extracellular fluid. Swelling Localized or Generalizedtumor Localized or Generalized Dependent action of gravity
Tansudate or Exudate? Exudate Inflammatory waterPart of the inflammatory reaction Rubor, dolor, calor, tumor Purposeful and intentional Localized
Tansudate or Exudate? Transudate Leakage, not part of healingIncreased hydrostatic pressure Heart failure Lymphatic obstruction Decreased oncotic pressure Decreased albumin
Congestive Heart Failure
Congestive Heart Failure
Chronic Passive Congestion, Nutmeg Liver
Chronic Passive Congestion
Water in Hollow Spaces Hydrothorax Hydropericardium HydroperitoneumAscites
Healthy Blood ClottingPlatelets Vessels Clotting Proteins
Thrombosis A pathological clotA clot forming in the fixed vascular system.
Thrombosis Endothelial damage Stasis and clotting factor activationClotting factor abnormalities Too many clotting proteins Pregnancy Cancers Too little inhibition Abnormal factors Leiden Factor (abnormal V)
Thrombosis Arterial Side Thrombi Venous Side ThrombiPlatelet activation Endothelial cell injury Venous Side Thrombi Stasis Clotting factor activation
Coronary Artery ThombosisAngiogram
Acute Myocardial Infarction
Aneurysm with Thrombus
Deep Leg Vein Thrombosis
Airplane Travel Gunner turret
Outcomes of a DVT
Embolus Space occupying mass moving in the fixed vascular systemBlood clot Bone Fragments Amniotic Fluid Air
Infarction Anemic Hemorrhagic End artery supply No blood WhiteVenous occlusion Loose tissues Dual blood supply Red
Shock Poor perfusion Tissue hypoxia Tissue acidosis Many causesPoor pumping by heart Low blood volume Loss of fluid Overwhelming infections
Types of Shock Cardiogenic Hypovolemic Anaphylaxis SepticDecreased output Hypovolemic Blood loss Fluid loss Anaphylaxis IgE and histamine Septic Gram negative rods Toxins
What Happens Next? Compensated Decompensated Irreversible Fluid shiftsProgression possible Irreversible No recovery
The Shock Spiral
Summary Fluid shifts Excessive tissue water Clot formation ThrombosisOncotic & Hydrostatic Pressures Excessive tissue water Exudate vs. Transudate Clot formation Vessels, platelets & proteins Thrombosis Pathological clot Arterial = endothelial damage & platelet activation. Venous = stasis and factor activation
Summary Infarction Ischemic = end artery organHemorrhagic = venous or dual blood supply Tissue vulnerability Brain Kidney muscle
Hemodynamic Disorders. Fluid Distribution ~60% of lean body weight is water ~2/3 is intracellular ~1/3 is extracellular (mostly interstitial) ~5% of total.
Hemodynamic Disorders Dr. Raid Jastania. Intended Learning Outcomes 1.Students should be able to define edema, congestion, hemorrhage, thrombosis and.
HEMODYNAMIC DISORDERS, THROMBOSIS AND SHOCK
Hemodynamics, Thromboembolism and Shock Review with Animations Nicole L. Draper, MD.
Hemodynamic Disorders, Thrombosis & Shock
Edema, Hyperemia and Congestion
Edema Excess fluid in the tissues Intracellular Edema Extracellular Edema.
The left frame shows marked narrowing as seen by angiography. The right frame shows the histology of the narrowed area. There is marked thickening of.
Hemodynamic Disorders د. بنان برهان محمد ماجستير / هستوباثولوجي.
Hemodynamic Disorders. Hyperemia and Congestion Increased blood volume in a certain tissueIncreased blood volume in a certain tissue Hyperemia is an active.
Tissue Fluid Formation and Oedema
60% of lean body weight = water (2/3) intracellular. (1/3)extracellular (interstitial fluid) 5% blood plasma. edema = an accumulation of interstitial.
Happy Year. Awatif Jamal, MD, MSc, FRCPC, FIAC Consultant & Associate Professor Department of Pathology King Abdulaziz University Hospital.
Shock It is a sudden drop in BP leading to decrease
Hemodynamic Disorders (Disorders of blood flow)
HEMODYNAMIC DYSFUNCTION May 19, 2008 Pathophysiology Premed 2 Dr. ROOPA.
Hemodynamic Disorders (Disorders of blood flow) Dr. Abdelaty Shawky Dr. Gehan Mohamed.
Weeks 4 and 5 Disturbances of Blood Flow Dr.İ.Taci Cangül Bursa-2008.
Thrombosis and Embolism. Thrombus Thrombus: a blood clot occurring in a vessel or the heart Thrombus: a blood clot occurring in a vessel or the heart.
Hemodynamics & Cellular Phases Types of Exudates (Role of Chemical mediators in inflammation)
Oedema Caused by increasing capillary filtration: - Increased capillary hydrostatic pressure: - Decreased oncotic pressure - Increase capillary permeability.
Hemodynamics 4 Dr. Hiba Wazeer Al Zou’bi. Embolism An embolus is a detached intravascular solid, liquid, or gaseous mass that is carried by the blood.
Chapter 3 Disorders of Vascular Flow Yiran Ni M.D
EDEMAEDEMA Fluid extravasation and accumulation in the interstitial spaces.
1.Pulmonary Vascular Disease 2.Pleural Disease Prof. Frank Carey.
HEMODYNAMIC DYSFUNCTION Pathophysiology Premed 3 Dr. ROOPA.
Acute inflammation 1 By Dr. S. Homathy.
Capillary Circulation & Edema Formation Dr. Eman El Eter.
By Dr Abiodun Mark. A. Identify the slide. What is going on with the organ?
Pulmonary Vascular Disease. Pulmonary Circulatuion Dual supply Pulmonary arteries Bronchial arteries Low pressure system Pulmonary artery receives.
Shock & Heamorrhage Dr. Eman EL Eter.
E MBOLISM An embolus is a detached intravascular solid, liquid, or gaseous mass that is carried by the blood to a site distant from its point of origin.
Lungs are distended and red
Capillary Circulation & Edema Formation
1 Fluid and Electrolyte Imbalances. 2 3 Body Fluid Compartments 2/3 (65%) of TBW is intracellular (ICF) 1/3 extracellular water –25 % interstitial fluid.
Infarct: Definition: An infarct is a localized area of ischemic necrosis resulting from sudden and complete occlusion of its arterial blood supply without.
2nd Year Pathology 2010 Vascular Disturbances I Oedema, Hyperaemia and Haemorrhage.
Shock & Hemorrhage Dr. Eman EL Eter. Objectives By the end of this lecture the students are expected to: Define circulatory shock. List types and causes.
Hemodynamic Disorders, Thrombosis, and Shock Dr Hisham Alkhalidi.
Anatomy Overview THE CIRCULATORY AND LYMPHATIC SYSTEMS.
The Physiology of Shock
Interventions for Clients in Shock. Shock Can occur when any part of the cardiovascular system does not function properly for any reason Can occur when.
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