1. The CART Fund Coins for Alzheimer’s Research Trust A project of Rotary Clubs of Southeast US

2. Rotary International District 7570

3. My Classmate Governor Byron (07-08) and lovely wife Kathy Introduced by Assistant Governor Mary Miller

4. In Governor Byron’s December 2007 Newsletter, this photo and caption appeared together. Youth Exchange from page 1

5. Governor Elect Woody and First Lady Elect Lori

6. What we will cover today What is Alzheimer’s disease? How does Alzheimer’s affect the brain? What is CART? CART History Example CART Research Grants

7. Alzheimer’s Disease What you need to know

8. Alzheimer’s (AHLZ-high-merz) disease is brain failure -a progressive brain disorder that gradually destroys brain cells and affects a person's memory, ability to learn, make judgments, communicate, and carry out basic daily activities. Alzheimer’s is not normal aging. It is a progressive, fatal disease, the cause is unknown and it has no cure.

9. New meanings for familiar Words * Sun-downing * Wandering *Elopement

10. Alzheimer’s Disease: From Basic Research to Disease Cure The CART Fund Columbia, SC May 7, 2008 Sanjay W. Pimplikar Cleveland Clinic

11. We do not know for sure! Amyloid hypothesis What causes AD?

12. Alzheimer’s destroys brain cells There are 100 billion nerve cells, or neurons, creating a branching network. Signals traveling through the neuron forest form memories, thoughts and feelings. Alzheimer’s destroys neurons, thus also destroying memories, thoughts, impulse control, personality, etc

13. Aβ AICD AD

15. Alzheimer’s causes the brain to shrink (due to the death of neurons)

16. History of CART.  In October 1995, the Sumter, S.C., Rotary Club initiated the effort to prove CART works by conducting an eight month testing program which was highly successful  July 1996: District 7770 in South Carolina adopted CART as a project.  April 1999: Our first grant of $100,000 is made to Emory University's Alzheimer's Research Center under the leadership of Dr. Allan Levey. AFAR ( American Federation for Aging Research).

17. History of CART (cont).  In the 18 months from January 1999 until June 2000, 10 more Rotary districts of the Carolinas and Georgia adopt CART as a project. The first Board of Directors meeting was held in November 2000, bylaws were adopted. They state that 100% of donated funds must go to Research!!  Each district that joins the CART program has two representatives on the board and two votes. The District Chair and the DGN

19. Success to date: $3.5m

21. This is how we are related

22. 1999 Emory University: Allan I. Levey, M.D. Ph.D. and Jim Lau 2001 Case Western Reserve University: Karl Herrup, Ph.D. and Gary Landreth 2003 University of Pennsylvania: John Q. Trojanowski, M.D. Ph.D. History of CART Awards

23. 2006 University of Texas Medical Branch: Claudio Soto, Ph.D. 2007 Mayo Clinic Jacksonville: Todd E. Golde, M.D., Ph.D. 2008 The Cleveland Clinic: Sanjay W. Pimplikar, Ph.D. 2009: Mayo Clinic, Jacksonville, Fl: Dr. Malcom LeissringS, Ph.D. History of CART Awards

24. 2010 University of Kentucky: Paul Murphy, M.D. $250,000 2010 University of Wisconsin-Madison: Dr. Luigi Puglieli, Ph. D. $150,000 2010 University of Pennsylvania: Dr. Kurt Brunden, Ph.D. $50,000 History of CART Awards

25. 2011 University of Pennsylvania: Dr. Kurt Brunden $250,000 2011 Case Western: Dr. Gary Landreth $100,000 2011 Mass General Dr. Brad Hyman $50,000 History of CART Awards

26. 2012 Dr. Maya Koronyo-Hamaoui Cedars Sinai, Oakland, CA. $250,000 2012 University of Washington Dr. Valarie Daggett, Ph. D. $100,000 History of CART Awards

27. How devastating is AD on a personal level. We lose contact with the individual that we knew. How do we know what they are thinking and feeling? How do they see themselves?

28. 1967 1996 1997 1998 1999 2000 William Utermohlen: Self portraits “..depict sadness, anxiety, resignation, feeling of feebleness and shame.” (NY Times, Oct 24, 2006)

29. You can help!! Lets find the cause, and find the cure/prevention for this dreaded disease!!