1. Healthy Mind, Healthy Sight.

2. u Dr. Guy Eakin, BrightFocus Foundation u Dr. Elia Duh, Johns Hopkins University u Dr. Seth Margolis, Johns Hopkins University Healthy Mind, Healthy Sight.

3. BrightFocus Foundation  A Non-Profit Organization  Based in Clarksburg, Maryland  Supporting Research and Education to Save Mind and Sight

4. One in 16 Americans, age 40 and above, has Alzheimer’s disease, macular degeneration, or glaucoma. The Need for Cures is Great

5. Support Innovative, Cutting-Edge Research  BrightFocus has awarded more than 1,000 grants totaling $130 million. More than $26 million awarded in last four years. Our Research Mission

6. Providing the Public with Information:  Risk Factors  Early Detection /Diagnosis  Current Treatments  Coping Strategies for Patients and Caregivers Public Education

7. Glaucoma and Age-Related Macular Degeneration Elia Duh, M.D. Wilmer Eye Institute Johns Hopkins School of Medicine October 30, 2013

8. Glaucoma and Age-related Macular Degeneration (AMD) u Two of the most common causes of blindness in the United States u Risk factors: – AGE: especially over the age of 60 – Family history – Race

9. Glaucoma u Glaucoma: – Fluid builds up in the eye, so that the eye pressure rises – This higher eye pressure can damage the optic nerve over time

10. u Symptoms u Treatment u Research to improve treatments Glaucoma

11. Age-Related Macular Degeneration (AMD) u AMD: – Eye condition among people age 50 or older – It gradually damages (and even destroys) the macula u Dry form of AMD u Wet form of AMD

12. Age-Related Macular Degeneration (AMD) u Symptoms u Treatments u Research to improve treatments for AMD

13. Alzheimer’s Disease Dr. Seth Margolis Johns Hopkins University Department of Biological Chemistry Johns Hopkins School of Medicine October 30, 2013

14. Neurons Synapses Molecules Behavior Circuits

15. 040608010020(Years) Genetic mutation and Risk factors Misfolding and aggregation of A  and tau followed by plaques and tangles Inflammatory Cell damage Preventative Modifying Symptomatic Cell death Clinical diagnosis Abnormal Normal Amyloid Neuron Injury Memory Dementia Mild

16. Daniel Colon-Ramos Karl Deisseroth

17. Spine Abnormalities are a Hallmark of Cognitive Disorders Reviewed in Ramakers et al. 2002, TINS UnaffectedAffected Non-syndromic MR Down’s Syndrome Rett Syndrome Fragile X syndrome Phenylketonuria Angelman Syndrome Alzheimer’s disease

18. Spine density Age Wenbiao Gan Dendritic Spine Density Changes with Development

19. anti-N-E5 anti-EphB2 Braak 334556 Embryonic 8682931028988

20. Genetic Cross Between Alzheimer Mice Models and Ephexin5 Knockout Mice X FemaleMale Electrophysiological properties: Dendritic spine morphology: Learning and memory: Alzheimer Mice Ephexin5 - /Ephexin5 - Ephexin5 - /Ephexin5 + Alzheimer’s

21. If You Have Questions… u Visit our website: www.BrightFocus.org www.BrightFocus.org u Send us an email: info@BrightFocus.org info@BrightFocus.org u Give us a call: 1-800-437-2423