1. NIH Training Grants, Fellowships, and Career Development Awards Milton J. Hernández, Ph.D. Director Office of Special Populations and Research Training National Institute of Allergy and Infectious Diseases (NIAID)

2. Purpose of Ts, Fs, and Ks To ensure that we have an adequate number of highly trained scientists to meet our Nation’s present and future health research needs Ultimately we want to see new generations of independent biomedical investigators

3. Support by Career Stage- M.D. Track M.D. Faculty Position Award Types Your Career Stage High School Student Medical Student Clinical Training Phase Research Training Phase Independent Investigator T35T32 Diversity Supplements F32 K01 K08 K23 K22K99 or R00 K99/R00 K02F33K24 T35- NRSA Short Term Institutional Research Training Grant T32- NRSA Institutional Research Training Grant F32- NRSA Individual Postdoctoral Fellowship K01- Mentored Research Scientist Development Award K08- Mentored Clinical Scientist Research Career Development Award K23- Mentored Patient-Oriented Research Career Development Award K24- Mid-Career Investigator Award in Patient-Oriented Research K22- Different names for this transition award K99/R00- Pathway to Independence Award K02- Independent Scientist Award F33- NRSA Senior Postdoctoral Fellowship

4. Support by Career Stage- Ph.D. Track Ph.D. Faculty Position Award Types Your Career Stage High School Student Graduate Student Independent Investigator T32 Diversity Supplements F32K22K99 or R00 K99/R00 K02F33K01 Postdoc Phase F31

5. General Principles

6. Training Grants (Ts) NRSA- National Research Service Award Legislated, program began in 1974 (P.L. 93-348) Multi-slot awards Domestic institutions only Fund training programs for pre- and postdocs in any scientific area within our scientific mission Can be basic or clinical Trainees work in a mentor’s lab MDs, PhDs, DVMs Awards go the best training programs in the Nation

7. Fellowships (Fs): NRSA- National Research Service Award Legislated, program began in 1974 (P.L. 93-348) Individual awards under a mentor Training can be at domestic or foreign institutions Fund pre- and postdoc trainees in any scientific area within our scientific mission Can be basic or clinical- most are basic Most awardees are for Ph.D.s

8. Career Development Awards (Ks) Individual awards Mostly for MDs More senior award than a fellowship Some mentored others not Newer ones (K22 and K99/R00) are transition awards- for MDs and PhDs

9. Mechanisms

10. Training Grants Some all predoc/some all postdoc Most are a mixture of slots Funds are mostly for tuition and trainees Training Related Expenses may be used to defray costs such as staff salaries, equipment, research supplies, and other expenses directly related to the training program Costs:  Tuition- 60% of requested tuition, capped at $16,000 ($21K for MD- PhD programs)  Stipends- $20,772 pre/ postdoc $36,996 (level 0)-$51,036 (level 7)  Training Related Expenses- $4,200 pre/$7,850 (post); both include health insurance  Travel- $400-$1000  F&As- 8%

11. F31s- Ruth Kirschstein NRSA Awards for Individual Predoc Fellowships to Promote Diversity in Health-related Research Predoc fellowship for minorities and students with disabilities Individual awards Cannot change the scope, move fellowship, or change mentor without prior NIH approval Tuition- 60% of requested tuition, capped at $16,000 ($21K for MD-PhD programs) Stipends- $20,772 pre Training Related Expenses- $4,200 includes health insurance Travel- $400-$1000 F&As- 8%

12. F32s Postdoc Fellowships Postdoc only Individual award Cannot change the scope, move fellowship, or change mentor without prior NIH approval Stipends- $36,996 (level 0)-$51,036 (level 7)  Training Related Expenses- $7,850; includes health insurance  Travel- $400-$1000  F&As- 8%

13. F33s Senior Postdoc Fellowships Not for postdocs who have been postdocs a long time Used for associate or full professors who want to go off on a sabbatical For MDs or PhDs Few applicants- too little money Stipend = $51,036 Training Related Expenses- $7,850; includes health insurance Travel- $400-$1,000

14. K01 Mentored Research Scientist Development Award Used in different ways by ICs MDs or PhDs 3-5 years Salary: $75,000/ yr + FBs Research Support: $20,000/yr F&As= 8%

15. K02 Independent Scientist Award Best candidate is a “senior” assistant professor or “junior” associate professor Close to or just got promoted and tenured Must have independent grant support Best award to have: R01 MDs (very few) and PhDs Salary support only $75,000/yr + FBs for 5 years Gives up salary support from all other NIH grants! Relatively few applicants F&As= 8%

16. K08- Mentored Clinical Scientist Development Award K23- Mentored Patient-Oriented Research Career Development Award K08- for basic research project K23- for clinical/ patient-oriented project K08- 3 or 5 yr award  3 yrs for more senior individual  5 yrs for more junior individual, but must justify a “didactic” 2 yr phase Salary: $75,000 + FBs/ yr Research Support:  K08- $20,000/yr  K23- $25,000/yr F&As= 8%

17. K24 Mid-Career Investigator Award in Patient-Oriented Research Purpose: to provide support for clinician investigators to allow them protected time to devote to patient-oriented research (POR) and to act as research mentors primarily for junior clinicians 3-5 years MDs Salary- 25-50% at institutional rate (maximum Congressionally-mandated level) + FBs Research Development Support- $50,000 F&As= 8%

18. K25 Mentored Quantitative Research Development Award For individuals from a quantitative background who want to apply their expertise to a biomedical problem For engineering, mathematics, computer science- NOT individuals who are already working in a biomedical or epidemiological area 3-5 years Salary: $75,000 + FBs Research Support: $20,000 F&As= 8%

19. K22 Research Scholar Development Award Transition award for postdocs moving to positions of assistant professor Two-phased application Phase 1  Scientific merit  No institution yet If applicant gets a fundable score, they have a year to find a position as assistant professor Phase 2  Assistant Professor  Own lab  Significant start-up funds  Little teaching/ no administrative responsibilities F&As= 8%

20. K99/R00 Pa thway to Independence Award Transition award for postdocs moving to assistant professors positions Has mentored phase Citizenship and green card not required- new feature for any K Has a mentored phase (K99) and an independent phase (R00) VERY competitive

21. Contact me: mh35c@nih.gov 301-496-3775