Date of Birth : Tegal (Central Java), 23 September 1933QUALIFICATIONS: 1938 – 1947: Elementary School 1948 – 1951: High School 1951 – 1958: Medical Faculty.

Date of Birth : Tegal (Central Java), 23 September 1933QUALIFICATIONS: 1938 – 1947: Elementary School 1948 – 1951: High School 1951 – 1958: Medical Faculty at University of Indonesia, Graduated in 1958 1958 – 1961: University of California, San Francisco, Ph.D. degree in Pharmacology. Thesis: The Inhibition of Alcohol Dehydrogenase by Chlorpromazine and other Phenothazine Derivates MEMBERSHIP: 1970 - 1990: Member/Founder Yayasan Pengembangan Sumber Daya Manusia 1996 - 2006: Member Komnas Perempuan 1985 - Present : Member/Founder Yayasan Pengembangan Kreativitas 1990 - Present : Member Yayasan Keanekaragaman Hayati Indonesia 1990 - Present : Ketua Yayasan Pendidikan Kalbe 2005 - Present : Member Komnas Lansia 2005 - Present : Ernst & Young Lifetime Entrepreneurial Award 2008 - Present : Vice Chairman of Advisory Board, Indonesian Stem Cell Association / Asosiasi Sel Punca Indonesia (ASPI) 2010 : Honorary Reviewer Ristek Kalbe Science Award (RKSA) Curriculum Vitae Dr. Boenjamin Setiawan, Ph.D.

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.2

 Ageing begins the day we are born  There is no single measure of how “old” a person is  Ageing is highly individualized  Ageing proceeds at different rates in different people, and within different systems of the body  Ageing is GENETIC and the secret is stored in the DNA

Many theories to include:  Hereditary Factors, stored in DNA  Loss of cellular mass and ability of cells to divide and replicate, STEM CELLS  Accumulation of waste materials that clog cells and cause them to die, TELOMERASE  Oxidative damage as a result of normal METABOLISM caused by FREE RADICALS, ROS, use ANTIOXIDANTS  Changes in structure of connective tissue No single theory adequately describes the aging process

 Physical changes related to “Normal” aging ARE NOT disease  Changes occur in most body systems to include: 1. Sensory System : Hearing, Vision, Balance, Taste buds, etc. 2. Cardiovascular system 3. Central Nervous System 4. Skin, Muscles and Bones 5.Digestion system 6.Respiratory system 7.Immune system 8.Endocrine system 9.All Organ System starts to Degenerate

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.6 1. Oxidative Damage – ANTI-OXIDANTS 2. Cell DNA Damage 3. Mitochondrial Damage 4. Lipofuscin Accumulation 5. Chronic Inflammation - MESENCHYMAL STEM CELLS 6. Immune System Compromise - MSC 7. Neurological Degeneration 8. Declines in Hormone Levels–Growth Hormone, Testosteron 9. Susceptibility to Cancers 10. Susceptibility to Cardiovascular Disease 11. Telomere Shortening and Damage 12. Programmed Epigenomic Changes 13. Stem Cell Supply Chain Breakdown –STEM CELL SUPPLY

 Stem Cell Therapy  Regenerative Medicine  Human Cloning  Genomics  Induced Pluripotent SC  The Human Genome Project  Genetically Modified Crops  Biological Agents in Bioterrorism Boenjamin Setiawan,dr.,Ph.D. 7 Presentasi 16 Sept.2011, FIMA, YARSI Special edition to celebrate the 50 th anniversary of the discovery of DNA: February 17, 2003

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.8 Global Aging

10 Presentasi 16 Sept.2011, FIMA, YARSI

 'Healthy aging' is an oxymoron like a healthy dying or a healthy disease  More accurate terms instead of 'healthy aging' would be a delayed aging, postponed aging, slow aging, or negligible aging (senescence) Boenjamin Setiawan,dr.,Ph.D. 11 Presentasi 16 Sept.2011, FIMA, YARSI

Boenjamin Setiawan,dr.,Ph.D.12 World’s oldest person celebrates 129 th birthday, died March 2007 According to national records, Hernandez was born on May 3, 1878, in one of the country's central provinces, where she gave birth to 13 children. She now has 60 grandchildren, 80 great-grandchildren and 25 great-great grandchildren.

 Consist of 12 Organ Systems  Consist of 220 types of Tissues  Consist of 50-100 trillion cells  Consist of 100 billion neurons  Consist of 46 chromosomes (22 pairs and x and y chromosomes)  Consist of 30.000 genes  Consist of 3,2 billion base pairs Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.14

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.15 50-100 Trillion Cells form the Building Block of the Human Body

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.17 How are ES Cells Generated?

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.19 The blastocyst is the stage of development (~1,000 cells) at which the embryos inner cell mass (ICM) forms. It is the ICM that harbors ES cells. Stem cells exist only fleetingly at this stage of development

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.20 5 days of development Who did it first? In 1998, Prof. James Thomson, U. Wisconsin research team isolated stem cells from IVF- blastocysts In 1998, Prof. James Thomson, U. Wisconsin research team isolated stem cells from IVF- blastocysts

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.26 Embryonic Stem cells: - spare embryos, from IVF - special purpose embryos - cloned embryos Adult stem cells: - adult tissue, - Bone marrow, Peripheral blood, Adipose tissue, Lung, Liver, Pericytes Other sources: - aborted fetuses - umbilical cords Sources of stem cells

1. Culturing and multiplications of hUCB stem cells for BURNS and CHRONIC WOUNDS 2. Culturing and multiplications of Chondrocytes for Osteoarthritis 3. Culturing and multiplication of Autologous MNC/EPC from Peripheral blood for AMI and Heart failure 4. Culturing hUC. MSC for Stroke and Cerebral Palsy 5SCI Developed VascGrow a Cocktail to Grow and Differentiate Human EPC Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.27

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.28 Reagents and consumables  Controlled storage  Controlled temperature for refrigerators  Controlled SOPs for procedures  Certificate of analysis Cell Banking, Processing and Analysis Facility

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.29 Stem Cells Isolation from Lipoaspirates for further Research Application - Routinely prepares Mesenchymal Stem Cell isolation from lipoaspirate - Collaborates with several Plastic surgeons - On going research to study several distinct molecules

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.30 Clinical Grade  Standardized procedures  Provide cells for stem cells clinical trials  Allogeneic & autologous Cell Banking, Processing and Analysis Facility  Cryopreservation facility (vapour phase)  Controlled Transported samples (temperature logger)  Complete report of product quality and evaluation  GMP Facility

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.31 SCI projects Stem Cell Research Division 1. Cell Analysis, Processing and Banking Facility 2. Immunogenicity Characterization of Mononucleated Cells Originated from UCB 3. Endothelial Progenitors Cell Expansion - scientific explanation for allogeneic UCB MNC therapy - Determination of EPCs frequency as biological marker for vascular function & cardiovascular disease risk - MI, Rejuvenation, & anti-aging 4. Stem Cells Isolation from Lipoaspirates for further Research Application

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.32 Applications : Heart Failure in Harapan Kita Hospital Blood Collection 1 3 Medium 2 EPC culture Ready for EPC implantation Cells are collected and washed

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.34COMMERCIALIZATION  Windpipe Transplant

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.35  Beating Rat Heart Created In Laboratory: Method May Revolutionize How Organ Tissues Are Developed  ScienceDaily (Jan. 14, 2008) — University of Minnesota researchers have created a beating RAT heart in the laboratory

1. Repair, Molecular Changes in the Microenvironment through Paracrine Secretions of STEM CELLS 2. Replacement of dead cells with somatic stem cells in affected tissues/organs 3. Regeneration of all the functions of the affected tissues/organs 4. Rehabilitation of all the tissues/organs in a multi-organ failure 5. Rejuvenation the dream of everybody to be able to rejuvenate all the molecules, cells, tissues/organs of the body through changes/reprogramming of the DNA molecule with a protein cocktail (elixir of life) Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.36

Blood Diseases  Bone marrow transplants (BMT) are a well known clinical application of hematopoietic stem cell (HSC) therapy  HSCs can regenerate all of the different cell types in blood  BMT is used for the treatment of blood cancers like leukemia and lymphoma, as well as breast cancer and any other disease requiring immune system regeneration Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.39

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.40  The cardiovascular circulatory system’s main role is to transport nutrients and oxygen to the 50-100 trillion cells that makes up our body and remove the waste material from the body.  The most prevalent disease that affects the CVS is: 1.Atherosclerosis 2.Hypertension 3.Acute myocardial infarction 4.Stroke

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.43  Major Role of CNS: The main role of the nervous system is to relay electrical signals through the body. The nervous system directs behaviour and movement and, along with the endocrine system, controls physiological processes such as digestion, circulation, etc.  The most prevalent diseases that affect the CNS is Stroke, Parkinson’s disease, Alzheimer’s disease, ALS and Autism

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.44  The brain microvascular endothelium constitutes a major exchange area between the blood and the brain: it forms a physiological barrier, known as the blood-brain barrier (BBB), which plays a central role in maintaining cerebral homeostasis.

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.45 Hwang Mi-Soon: South Korea Paralyzed 19 years Multipotent adult stem cells injected into her spinal cord Currently: debilitating pain Published in 2005 (Cytotherapy)

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.46  Ische mic Stroke

Type 1 Diabetes  Patients lack pancreatic beta cells and cannot produce insulin  Insulin-producing structures similar to pancreatic islets have been generated from mouse ES cells in culture  It may also be possible to isolate pancreatic stem cells from adult tissue  Early stage of development Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.49

 Mesenchymal stem cells are used to be inserted into the synovial cavity where they transdifferentiate into chondroblasts and form new cartilage Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.50

Shinya Yamanaka, 45, working in Japan's Kyoto University with mouse cells, made the iPS breakthrough. He screened 24 candidate proteins before finding four that were able to reprogram adult cells, reverting them to their embryonic state. He and others then showed that these factors are also effective in human cells. James Thomson,49, a Development Biologist of the University of Wisconsin was the first to identify a slightly different group of factors that do the same Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.51

1. CRAN = Caloric Restriction Adequate Nutrition, Healthy DIET, Vegetables/ FRUITS 2. Regular Exercise, Walking and Weight Lifting 3. Have ACTIVE LIFESTYLE, WORK, NEVER RETIRE !! 4. Use BRAIN ACTIVELY, use INTERNET 5. Sharpen your SAW, have a regular BREAK 6. Take VITAMINS, ANTI-OXIDANTS, MINERALS and Hormones 7. HAVE A POSITIVE MIND, BE OPTIMISTIC !!! 8. BE HAPPY ALL THE TIME !!! 9. Use of Mesenchymal Stem Cells to slow down the Ageing Process Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.52

1. Adult stem cells can be obtained from BM, hUCord, Dental pulp, Adipocytes and Peripheral blood, It will not create any ethical problems 2. Adult stem cells from fetuses and hUC are the most PLASTIC 3. Embryonic stem cells obtained from the INNER CELL MASS for THERAPEUTIC purposes are allowed in 38 countries (UK, Sweden, Belgium, Netherland, China, India, Korea, Taiwan, Singapore, Malaysia etc.) 4. Embryonic stem cells for reproductive cloning is not allowed in ALL COUNTRIES Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.53

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.54 5. Mesenchymal Stem Cells from BM, Fetuses, hUCord, can be used as Progenitor Neuronal Cells for transplantation in Neurodegenerative Diseases. 6. EPCs as well as MSC from BM, hUCord, Adipocytes and peripheral blood can be used for AMI, Heart Failure, Auto-immune diseases, and can clear Sclerotic Plaques in Arteries, etc. 7.Stem Cell Research should become a PRIORITY to be carried out in Indonesia and the rest of the WORLD to SLOW DOWN THE AGEING PROCESS 8.Academic Institutions, Business and Government (ABCG) must Cooperate Closely to Stimulate RND for the Benefit of Society

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D.55 5. Mesenchymal Stem Cells from BM, Fetuses, hUCB, can be used as Progenitor Neuronal Cells for transplantation in Neurodegenerative Diseases. 6. EPCs as well as MSC from BM, hUCB, Adipocytes and peripheral blood can be used for Acute Myocardial Infarction 7. Stem Cell Research should become a PRIORITY to be carried out in Indonesia 8. Academic Institutions, Business and Government (ABCG) must Cooperate Closely to Stimulate RND for the Benefit of Society

Presentasi 16 Sept.2011, FIMA, YARSIBoenjamin Setiawan,dr.,Ph.D. Thank You Live with the 5 E’s: Energy, Enable, Enthusiasm, Empower, and Enrich. 56

Date of Birth : Tegal (Central Java), 23 September 1933QUALIFICATIONS: 1938 – 1947: Elementary School 1948 – 1951: High School 1951 – 1958: Medical Faculty.

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Date of Birth : Tegal (Central Java), 23 September 1933QUALIFICATIONS: 1938 – 1947: Elementary School 1948 – 1951: High School 1951 – 1958: Medical Faculty.

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Presentation on theme: "Date of Birth : Tegal (Central Java), 23 September 1933QUALIFICATIONS: 1938 – 1947: Elementary School 1948 – 1951: High School 1951 – 1958: Medical Faculty."— Presentation transcript:

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