1. 33F Skin patches 3

2. 2

3. 1

4. McCune Albright

5. 13M Bone Age - ESRD 2

6. 1 year later 1

7. Healing rickets distal ulna

8. 25M 1

9. Osteopoikilosis Benign sclerosing bone dysplasia Melorrheostosis Osteopathiastriata

10. 35M Chronic illness 6

11. 5

12. 4

13. 3

14. 2

15. 1

16. ROD

17. 66F 3

18. 2

19. 1

20. Fibrous Dysplasia

21. 43F

23. RTA-ROD

24. 29M

27. POFD

28. 53M

32. Renal Tx – ROD - AVN

33. 57F Bone pain 8

34. 7

35. 6

36. 5

37. 4

38. 3

39. 2

40. 1

41. Gauchers

42. 49M Bone pain

44. Poly osstotic fibrous dysplasia

45. 25F

46. 4

47. 3

48. 2

49. 1

50. Primary oxalosis secondary hyperparathyroidism Primary Hereditary hyperoxaluria AR, enzyme deficiency - carboligase Diffuse calcium oxalate deposits Secondary Disturbance of bile acid metabolism Usually diseases of terminal ileum 25F

51. Acroosteolysis Tuft CVD, Psoriatic, Neuropathic, Thermal, Trauma, HPT, Porphyria, Epidermolysis bullosa, Phenytoin toxicity, Subungal exostosis, Snake venom Middle HPT, Hajdu Cheney, PVC Periarticular Psoriatic, Erosive OA, HPT, Thermal injury, Scleroderma, Multicetric reticulohistiocytosis

52. 20F 1

53. Familial osteolysis 20F

54. 7M Kyphosis

55. Mucolipidosis 3 - PseudoHurlers

56. Newborn

59. 3mM Short

61. 32M Stiffness and decreased ROM since child

63. Trevors disease Dysplasia epiphysialis hemimelica 32M Stiffness and decreased ROM since child

64. 29F Short stature 8

65. 7

66. 6

67. 5

68. 4

69. 3

70. 2

71. 1

72. Diastrophic dwarf 29F Short stature

73. 57M L hip pain 2

74. Sandwich vertebrae - Osteopetrosis 57M L hip pain 1

75. Osteopetrosis Marble bone, Defective osteoclasts AR, Infantile, Systemic, Leukaemia AD, Adult, Fxs, anaemia, CN palsy Sclerotic, peri and endosteal Erlenmyer flask Bone in bone, sandwich vertebrae Calvaria and mandible spared 57M L hip pain

76. 67F Lump 2

77. 1

78. Fibrous Dysplasia Common Hamartomatous fibro-osseous metaplasia 70% monoostotic Polyostotic tends to be unilateral Usually expansile Shepherds crook, ground glass Any bone, but spine unusual 67F Lump

79. Variable patients Same condition 6

80. 5

81. 4

82. 3

83. 2

84. 1

85. Pseudohypoparathyroidism X-linked, renal and skeletal resistance to PTH Short, retarded, Decreased Ca, normal/increased PTH Brachydactyly 1,4,5 MC Ca basal ganglia, skin, SubQ Variable patients Same condition

86. Same condition Various patients 8

87. 7

88. 6

89. 5

90. 4

91. 3

92. 2

93. 1

94. Dermatomyositis Damaged chondroitin sulfate Atrophy, oedema, necrosis of muscle 30-60, F>M Calcification extremities and girdles Pointing of tufts Ass. Malignancy, lung, kidney, ovary, breast Same condition Various patients

95. 37F acute torticollis, stiffness and shortness of breath

96. * Fibrodysplasia ossificans progressiva

97. MOP / Stone man Rare, AD, sporadic Presents in childhood Stiffness, Heterotopic ossification Malformed fingers and toes Bone morphogenic protein (BMP) signaling pathway problem Fibrodysplasia ossificans progressiva

98. Variable ages increasing stiffness

99. * Fibrodysplasia ossificans progressiva

100. MOP / Stone man Rare, AD, sporadic Presents in childhood Stiffness, Heterotopic ossification Malformed fingers and toes Bone morphogenic protein (BMP) signaling pathway problem Fibrodysplasia ossificans progressiva

101. 48M joint pains and dark pigmentation on ears

102. Alkaptonuria * Alkaptonuria / Ochronosis

103. Absence of homogentisic acid oxidase Pigmentation Arthropathy Osteoporotic with dense disc calcification Larger joints show DJD

104. 6mM Calcareous nodules

105. Idiopathic calcinosis universalis * Idiopathic calcinosis universalis

106. Rare, unknown cause Infants - subcutaneous Children - spreads to muscles Calcium phosphate and carbonate Serum calcium and phosphorous normal DDx - DMS, HPT, Calcium gluconate

107. 50F Life long problems

108. * OGI

110. 45M ITC

113. 23M Hemophilia

114. 23M

116. Mastocytosis

117. 65  Mastocytosis

118. 65  Mastocytosis

119. 65  Mastocytosis

120. 65  Mastocytosis

121. 65  Mastocytosis

122. 65  Mastocytosis Histamine release causes lucency, bodies reaction causes sclerosis. Mastocytosis

124. Cherub - Fibrous Dysplasia

126. 16mF Dysostosis multiplex

128. 4M Morquio’s

130. 24F NF1

132. 22F Calcinosis Interstitialis Universalis Dermatomyositis

133. McCune Albright

134. 9F McCune Albright

135. Polyostotic fibrous dysplasia

136. 24M Polyostotic fibrous dysplasia

138. 28BF mass in shoulder

139. Idiopathic Tumoral Calcinosis *

140. Periarticular calcified masses Shoulder, hip, elbow B>W, M=F Recur if resected Elevated phosphate, normal calcium Renal tubular phosphate resorption

141. 63F ITC

143. Rib osteochondroma

146. Massive osteolysis

149. Multiple hereditary exostoses

151. Multiple hereditary exostosis

152. Multiple hereditary exostoses 21mF

153. Multiple hereditary exostoses 21mF

154. Multiple hereditary exostoses

155. Newborn FLK

156. OGI

158. Camurati Engelman

161. Metaphyseal dysplasia