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Ace Inhibitors & the Kidneys A A Jameson
CHF ! RENIN RENIN Or Diuretic Drop in perfusion and GFR
CHF ! Angiotensin II Vasocontriction Increases Glomerular Pressure and Filtration
CHF ! Angiotensin II CHF ! ACE Inh. C.O. Ace Inhibitors Can reverse this compensator y mechanism and shut down urine output You hope increased C.O. will restore flow
Early Diabetes Characterized by Hyperfiltration Normal A II tone
CHF ! Angiotensin II Diabetes post ACE Angiotensin constriction removed Hyperfiltration and damage reduced
CHF ! Angiotensin II CHF w/ renal function preserved by A II CHF w/ renal function preserved by A II Secondary benefit from Prostaglandin dilation on the supply side
CHF ! Angiotensin II PG
NSAID + ACE Drip The combination removes both the Prostaglandin dilation and the Angiotensin Efferent constriction
Determinants of GFR GFR = Capillary filtration coefficient X Net filtration pressure. Increased glomerular Capillary filtration coefficient increases GFR.
REGULATION OF GFR Dr. Eman El Eter. Glomerular Filtration Rate (GFR) Defined as: The volume of filtrate produced by both kidneys per min Averages.
The Physiology of the Afferent and Efferent Arterioles.
Human Physiology Physiology of the Kidneys Chapter 13.
P. 954 Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings © 2012 Pearson Education, Inc.
Renal Blood Flow. Total renal blood flow: TRBF ~ 1270 ml/min ~ 20-25% of CO (5000 ml/min) ~ 90% to cortex Total renal plasma flow: TRPF ~ 700 ml/min.
Afferent arteriole Efferent arteriole. Filtrate is forced through holes in glomerular capillary walls Glomerular Filtration.
Renal Physiology Overview
Glomerular Filtration As blood flows through the glomerulus protein-free plasma filters through the glomerular capillaries into Bowmans capsule Normally.
RENAL BLOOD FLOW Value, Measurement, Autoregulation, Factors & Conditions affecting---
Filtration coefficient (Kf ): Kf = GFR / net filtration pressure -GFR for both kidneys is about 125 ml/ min,the -- -net filtration pressure is 10 mm Hg,
Glomerular Filtration and Regulation of Glomerular Filtration Rate Reference: Principles of Anatomy and Physiology; Tortora & Derrickson Chapter 26 Dr.
Mechanisms and Management in Acute Kidney Injury Paul Stevens Kent Kidney Care Centre.
Regulation of kidneys work. Role of kidneys in homeostasis maintenance.
Control and regulation of GFR and renal blood flow Sympathetic nervous system activation _decreases_ GFR. –Strong activation of renal sympathetic nerves.
Renal System: Functional unit is the Nephron. Ureter (2) Bladder (1) Urethra (1) Kidneys (2)
Mechanism of urine forming. The Nephron Is the Functional Unit of the Kidney Each kidney in the human contains about 1 million nephrons, each capable.
All things Renal Peer Support Zoulikha Zair. RAAS.
The Urinary System. Outline Introduction – Basic Anatomy & Function Kidneys –Nephrons JGA Apparatus Glomerular Filtration Tubular Reabsorption Tubular.
Kidney Regulation. ADH Antidiuretic hormone – Diuretic: promotes production of urine Regulate reabsorption by kidneys Osmoreceptors in hypothalamus –
Dr. Aya M. Serry Renal Failure Renal failure is defined as a significant loss of renal function in both kidneys to the point where less than 10.
Regulation of Na +, K + and water Chapter 14 pages
RENAL PHYSIOLOGY DR SYED SHAHID HABIB MBBS DSDM FCPS Associate Professor Dept. of Physiology College of Medicine & KKUH.
Lecture – 2 Dr. Zahoor 1. Basic Renal Processes Glomerular filtration Tubular reabsorption Tubular secretion Urine results from these three processes.
Diabetic Nephropathy. Over 40% of new cases of end-stage renal disease (ESRD) are attributed to diabetes. In 2001, 41,312 people with diabetes began.
Regulatory functions of the kidneys Reabsorption of water – Excretion of hypertonic depends on reabsorption of water from collecting ducts Reabsorption.
CARDIOVASCULAR PHYSIOLOGY BLOOD PRESSURE AND ITS REGULATION.
Chapter 24 – The Urinary System $100 $200 $300 $400 $500 $100$100$100 $200 $300 $400 $500 The Glomerulus Kidney Tubules Urine “Kidneying” “Urine Town”
Glomerulotubular Balance-The Ability of the Tubules to Increase Reabsorption Rate in Response to Increased Tubular Load.
Chapter 17 Physiology of the Kidneys Dr. David Washington.
Blood Pressure Regulation- Background info ► Water will go where there are high concentrations of Salt ► Increase in water = increase in volume ► Increase.
Hypertension Robbins: 525 to 530, Cecil:
Copyright © 2006 by Elsevier, Inc. Figure 26-3; Guyton and Hall Nephron: functional unit of the kidney.
By Dr. Adrienne Hicks. Cardiology Pulmonology Renal Gastrointestinal Endocrine Reproductive Neurology Musculoskeletal Psychiatry Pediatrics.
Chapter 25 - The Urinary System $100 $200 $300 $400 $500 $100$100$100 $200 $300 $400 $500 Gross Anatomy Nephron Anatomy Filtration Renal Tubules Urine.
David Sadava H. Craig Heller Gordon H. Orians William K. Purves David M. Hillis Biologia.blu C – Il corpo umano Excretory System and Salt and Water Balance.
By Jessica Davies. Angiotensin Converting Enzyme Inhibitors Used to help control Hypertension Also they help with heart failure, preventing strokes, and.
Driving Force of Filtration n The filtration across membranes is driven by the net filtration pressure n The net filtration pressure = net hydrostatic.
14 Lesson 14.1: Anatomy of the Kidney Lesson 14.2: Urine Formation, Storage, and Excretion Lesson 14.3: Diseases and Disorders of Excretory System The.
Renal Physiology 1 Dr Derek Scott See also your renal lectures from BI25B2. These are still on the School of Medical Sciences Website.
Na + Homeostasis. Sodium reabsorption by the nephron 1% 3% 6% 65% 25% Percentages give the proportion from filtered load reabsorbed Normally, only 1%
Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 44 Drugs Acting on the Renin- Angiotensin-Aldosterone System.
Chapter 25 Urinary system Lecture 15 Part 3: Urine Formation, GFR, Control of GFR Marieb’s Human Anatomy and Physiology Ninth Edition Marieb Hoehn.
1 Endocrine Involvement: 1. ADH antidiuretic hormone (vasopressin) is a peptide hormone secreted by the pituitary gland regulates the amount of water excreted.
RENAL FUNCTIONS & GFR Dr. Eman El Eter. What are the functions of the kidney? Regulation of water and electrolyte balance. Regulation of body fluid.
Figure 25.3b. Renal Vascular Pathway Figure 25.3c.
© 2012 Pearson Education, Inc. What is the composition of the filtrate in the capsular space? a. like urine, only more concentrated b. similar to water.
Major Functions of the Kidneys and the Urinary System 1.Regulation of blood ionic composition 2.Maintenance of blood osmolarity 3.Regulation of blood volume.
Pharmacology DOR 101 Abdelkader Ashour, Ph.D. 9 th Lecture.
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