16Glomerular Physiology Pathologic conditions:Renal Artery StenosisHypertension / Medication effectsMembrane problemsLead to blood in urine – hematuria-Loss of negative charge leads to protein in urine – proteinuria-Diabetes, Glomerulonephritis
28Renal Tubule Physiology Overview Prox. tubuleDistal Tubulesolute exchangereabsorptionCollecting ductimpermeable toimperm. toH2OsoluteADH +permeable to H2OLoop of HenleADH -impermeable
29Interstitium The tissue in between the tubules Function: AmmoniagenesisCountercurrent multiplierPathology:RTA, Loss of concentrating ability, AIN
30Countercurrent Multiplier Way to keep the concentrating ability of the kidney isolated from the rest of the bodyComponents:Urine flow with sodium chloride pumpBlood flow from Vasa RectaPathology:Sickle Cell /Trait, bladder obstruction
34Renal Physiology Endocrine Functions Renin – control of BPErythropoietin – turns on bone marrow to make red blood cellsVitamin D activation – regulates bone metabolism, Calcium, Phosphorus and Parathyroid Gland.
35Volume regulation Active Sensors Passive system Renal Autonomic nerves Like a system of lakes and spillways