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Rudy Dekeyser 21/04/05. origin of the species mission & objectives creating an innovative environment is basic high quality research compatible with tech.

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Presentation on theme: "Rudy Dekeyser 21/04/05. origin of the species mission & objectives creating an innovative environment is basic high quality research compatible with tech."— Presentation transcript:

1 Rudy Dekeyser 21/04/05

2 origin of the species mission & objectives creating an innovative environment is basic high quality research compatible with tech transfer?

3 origin of the species mission & objectives creating an innovative environment is basic high quality research compatible with tech transfer?

4 Origin of the species Ghent Antwerp Louvain Diepenbeek Brussels

5 Origin of the species Step 1. Flemish government evaluates the life sciences research [1994]

6 Origin of the species The 1994 conclusions: v big names in science v but lack of structural support critical mass translation in industrial activities

7 Origin of the species vDedicate a certain volume of an existing granting body to life sciences research danger: slice it thin lack of sustainability vEstablish a novel independent research institution danger: disturb the equilibrium lag phase The conventional approach:

8 Origin of the species Step 2. The VIB concept v unite existing quality v build synergy and critical mass research tech transfer

9 Origin of the species VIB – unite existing quality 60 biotech teams in 5 universities evaluation select 9 excellent teams

10 Origin of the species U2 U3 U4 U5 U1 VIB vzw

11 Origin of the species VIB – create critical mass v Flemish government invests 5y x 25M= = doubling research budget overnight = creating critical mass Framework agreement: long term commitment in depth evaluation every 5 year

12 Origin of the species VIB – create synergy v Framework agreement with universities key output: scientific publications 752 / October 2004 / volume 5

13 Origin of the species VIB – create synergy v Framework agreement with universities tech transfer: IPR – joint ownership – management: VIB – costs: VIB marketing/exploitation: VIB

14 Origin of the species VIB – create synergy vFramework agreement with universities tech transfer - return patent cost inventors VIB 50 univ 50 VIB Department 40 10

15 Origin of the species VIB – create synergy v Framework agreement with universities tech transfer – return UNIV: = 90% VIB: = 90%

16 Origin of the species VIB – key facts & figures v foundation:1996 v legal entity:not-for-profit v field:life sciences v budget 2004:~ 60 mio v headcount:~ 850

17 origin of the species mission & objectives creating an innovative environment is basic high quality research compatible with tech transfer?

18 Mission Molecular sciences to improve the quality of life

19 Objectives v conduct frontline basic research v translate inventions into products for the benefit of society v inform the public

20 origin of the species mission & objectives creating an innovative environment is basic high quality research compatible with tech transfer?

21 VIB - Research Major fields: vOncology vCardiovascular/angiogenesis vNeurobiology vInflammation/immunology vDevelopmental biology vPlant system biology vMicrobiology

22 TNF-R55 TNF membrane VIB - Research p50 p65 I B p50 p65 I B Ub P P nucleus p50 p65 NF- B dependent genes TNF-R75 FADD casp8 apoptosis P P IKK IKK / MAP3K TRADD TRAF2 P P inflammation Ub RIP ABIN A20

23 VIB - Research healthy colon Colitis ulcerosaCrohns disease Recombinant L.lactis, expressing IL-10 Novel treatment for IBD in clinical trial

24 VIB - Research VEGF mice show adult onset ALS phenotype Reduced levels of VEGF increase the risk for ALS VEGF promoter polymorphisms reduce VEGF expression

25 H 16 O Arg N Arc N C 16 O H C 18 O Ex.: Heatmap of ratios of amino-terminal peptides for 700 IDs from T-Lymphocyte VIB - Research Quantitative N-teromics According to reverse phase chromatography position According to ratio (O18/O16)

26 VIB - Research

27 VIB – Tech Transfer Tech Transfer = Technology Transfer = Knowledge Transfer = the movement of knowledge between different parties = the transfer of knowledge from an academic institution to industry = patenting, licensing and establishing start-ups = mining of knowledge => optimize knowledge creation

28 VIB - Research v Target:frontline v Create the environment: recognise excellence top performance => budget low performance => budget excellence bonus recruit internationally

29 39 nationalities 58% European countries 23 % Asia 11% N&S America 6,5 % Africa 1% Australia % internationalisation VIB – Research international recognition

30 VIB - Research v Target:frontline v Create the environment: recognise excellence up to date infrastructure

31 UGent-VIB research building

32

33 VIB - Research v Target:frontline v Create the environment: recognise excellence up to date infrastructure access to advanced technology platforms

34 VIB microarray facility

35 (Source: PhD thesis Kris Gevaert, 2000) VIB proteomics core facility

36 VIB Genetic Service Facility sequencing STR-genotyping SNP discovery SNP analysis

37 VIB technology – model organisms yeast drosophilazebrafish xenopusmousearabidopsis

38 VIB technologies Bio-informatics

39 VIB - Research v Target:frontline v Create the environment: Stimulate debate and interaction GLC VIB seminar VIB newsletter science clubs PhD program

40 VIB - Research v Quality assurance: IAB

41 Institutional Advisory Board 2004

42 VIB - Research v Quality assurance IAB SAB strategic plan organigram [critical density]

43 VIB - Research

44 v Quality assurance IAB SAB strategic plan organigram performance criteria

45 VIB - Research Performance criteria: v scientifically 45 publications in IF > 10 journals 125 publications in IF > 5 journals v education 35 PhDs v tech transfer 25 patent applications 50% granted 5 mio industry funding

46 VIB - Research X 2.7 X 3.3 IF > 10 IF > 5

47 facilitate the commercialisation of research results for the benefit of society promote economic growth job creation generate research to dept. records of invention IPR agreements existing companies start-ups research VIB – Tech Transfer

48 Disclosure and recording of inventions Policy: vadapt to academic environment vpro-active vminimize administrative hurdles vtreat with priority

49 VIB - Tech Transfer Inventions

50 VIB - Tech Transfer ROI-benchmark 3 2,5 2 1,5 1 0,5 0 V IB M /ROI Cal Tech ARCH Stanford Can. Inst. US Inst. US Univ.

51 VIB - Tech Transfer # patent applications

52 VIB - Tech Transfer Patent applications (PA) VIB: 48% ROI => PA Benchmark: 50% ROI => PA

53 VIB – Tech Transfer Priority filing EU US UK PCT filing 2 nd filing Search report National phase Written opinion Preliminary Examination Report Granting portfolio management

54 VIB – Tech Transfer Budgets/year - cumulative

55 VIB - Tech Transfer vPfizer vNovartis vJohnson & Johnson vSolvay vAbbott vBayer Licensing/R&D: some collaborators vInnogenetics vTibotec vGalapagos vCropDesign vAblynx vTigenix

56 VIB - Tech Transfer vconceptualize and write business plan vstrengthen the technology/product base via inlicensing vassist in bringing the team in place vroad show to raise venture money vassist in the due diligence process VIB operates in a very hands-on manner by playing the role of seed financier: Start-up: basic principles

57 VIB - Tech Transfer Start-up: case study - nanobody Broad application spectrum diagnostics/proteomics therapeutics immuno-affinity feed/food

58 VIB - Tech Transfer Start-up: case study – nanobody (1)Technology building secured access to 3 basic patents covering product claims and production methodology (VUB) filed 6 more patent families > 40 patent applications and patents (2) Strategic investments: VIB grant complemented with: tech transfer project IWT grant

59 VIB - Tech Transfer Start-up: case study – nanobody (3) Business plan (Ablynx) (4) Attract lead investor (GIMV) (5) Establish legal entity (VIB + GIMV) (6) Attract CEO (M. Vaeck, ex-COO Ceres) (7) Ad interim management recruit first employees rent lab space furnish labs establish contacts with potential licensees

60 Ablynx nv vBiopharma vFoundation:2001 vLocation:Ghent vCEO:Dr. Mark Vaeck vVenture Capital 1st round:5 M vInvestors:GIMV, BFV, Sofinnova, Gilde Venture Capital 2nd round:25 M New investors:Abingworth, Alta Partners Employees: 40

61 Devgen nv vBiopharma & agbio vFoundation:1997 vLocation:Ghent vCEO:Dr. Thierry Bogaert vVenture Capital 1st round:9.4 M vInvestors 1st round:GIMV, Abingworth, BVF Venture Capital 2 nd round : 29 M New investors : Advent, LSP, Rendex, ING, DV, KBC, M&M Employees : 95

62 CropDesign nv vAgbio vFoundation:1998 vLocation:Ghent vCEO::Dr. Johan Cardoen vVenture Capital 1st round:11 M USD vInvestors 1st round:GIMV, Atlas Venture, Sofinnova, BFF Venture Capital 2 nd round: 25.6 M New Investors: Gilde, ING, DV, Burrill Agbio, KBC, Technolife 2010 Employees: 70 Venture Capital 3th round: 16 M

63 Peakadilly nv vBiopharma vFoundation:2004 vLocation:Ghent vCEO:Koen Kas vCapital 1st round:VIB vIncome:3 mio vEmployees:10

64 Tech Transfer Start-ups: employees

65 VIB start-up Benefit for society: v multiple therapeutics under development v novel agronomically improved crop varieties under deveopment

66 VIB - Tech Transfer

67 Innogenetics VIB Bio- incubator 2 VIB Bio- incubator 1 Innovation& Incubation centre 2 (University of Ghent) Innovation & Incubation centre 1 (University of Gent) Crop Design Bayer Bio Science research facilities University of Ghent/VIB DeVGen Service Center for biotech Buildings planned or under construction Ghent Technology Park

68

69 Conclusion v scientific output and quality improved significantly v tech transfer output has increased from almost zero to significant

70 origin of the species mission & objectives creating an innovative environment is basic high quality research compatible with tech transfer?

71 Balancing science & Tech Transfer science technology basic applied Yearly avg # pubs Groups without collaboration Groups with collaboration Source: K. Debackere et al., in prep.

72 Balancing science & Tech Transfer Table 1a – average number of SCIE publications ( ) InventorsNon-inventors Complete sample35,811,7 Sample without outliers (# pubs < 90) 22,812,1 Source: K. Debackere et al., in prep.

73 Balancing science & Tech Transfer Conclusion: High quality basic science & tech transfer are compatible


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