1. EE3080 Design and Innovation Project Programme: Electromedical Technologies Coordinator: Asst. Prof. Justin Dauwels jdauwels@ntu.edu.sg School of Electrical and Electronic Engineering Nanyang Technological University

2. What is Biomedical Engineering? Biomedical engineering is a multiple discipline and high technology area. It is to provide solutions for health care industries and services. ELECTROMEDICAL technologies: electrical engineering applied to healthcare

3. Electrical Engineers Play a Key Role in Health Care Industries

4. Electrical Engineers Play an Key Role in Health Care Industries and Services 750  m Papillary muscle Septum 4-shank probe Circuits and electronics Measurement and instrumentation Pacemaker

5. Electrical Engineers Play an Key Role in Health Care Industries and Services ECG Brain Mapping from EEG Information and signal processing Medical imaging and image processing

6. Electrical Engineers Play an Key Role in Health Care Industries and Services Modelling and control Telemedicine

7. Biomedical Engineering is Exciting It is important: Health Caring and Life Saving It is profound and challenging: Nobel Prizes in Medicine in 1979, for the development of Computed Tomography (CT) and in 2003 for the development of Magnetic Resonance Imaging (MRI). It is High Tech =

8. Health Care Industry is Robust and Resilient in the Economic Crisis Performance of Different Sectors of NYSE (2007 – 2013)

9. Baxter Becton Dickinson Siemens Medical Instruments Medtronic GE Medical Boston Scientific GlaxoSmithKline MDS Analytical Technologies Perkin Elmer NTU Universities Polytechnics SGH NUH NCC SNEC NHC NNI Institute of Bioengineering and Nanotechnology Bioinformatics Institute Institute of Molecular and Cell Biology Defence Medical Research Institute Bioprocessing Technology Centre Laboratories for Information Technology Johns Hopkins Singapore Pte Ltd Hospitals Research Institutions SINGAPORE Companies Academic Institutions/ Government Boards Where do Biomedical Engineers work ?

10. Quantum Dots Probe DCE Imaging Photo-Thermal Imaging nanochannel microchannel Lab-on-Chip Spectroscopy- on-Chip Microscope-on- Chip Opto- & Nano- Fluidic Chips POC Sensor Platform Wearable Respiratory Monitoring Brain Disorder Diagnostic Telemedicine Elderly Home Monitoring Neuro-Device Implants Research at School of EEE on Electromedical Technologies 25 Active EEE Faculty Members Inspired by Clinical Needs Reputed for Impactful Research Wireless Sensing

11. Distributed Diagnosis & Home Healthcare (D2H2) Clinics and Hospitals Primary Care Provider Tele-Rehabilitation Other Specialist & Clinicians Emergency Room Personal Health Information Management System (PHIMS) Non-Contact Vital Sign Biosensors Wherever the patient is.. Intelligent Controller Internet Handheld Devices Home Healthcare Monitoring or Diagnostic System Wearable System Smart Homecare Monitoring Prof. Tjin Swee Chuan, et al

12. Bio-Imaging & Signal Processing DCE Imaging of Tumor Microcirculation Diagnosis/Treatment of Brain Disorders  The use of dynamic contrast-enhanced MR imaging (DCE MRI) and dynamic contrast- enhanced CT imaging (DCE CT) as a biomarker for anti-angiogenesis therapy  Neuro-electric Engineering for Curing Brain Disorders  Nasopharyngeal Cancer Diagnosis with Optical Coherence Tomography  Fluorescence Life-time Imaging for Medical Diagnosis of Cancerous Tissue  Development of Photo thermal Imaging system for imaging sub-cellular organelles  Processing and Classification of Heart Rate Variability Signals Nasopharyngeal Cancer Diagnosis with optical Coherence tomography

13. Bio-Nano Technology and Devices Point-of-Care Biosensor Platform Integrated LSPR Chip LSPR simulation Nanopattern fabrication Microscope on Chip (3D Ultrasound, CMOS Imager) Micro-fluidic Chips and Devices  Multilayer micro-fluidic chip (to form single tumor spheroid), device (for neuron culture)  Lab on Chip (Nano-Droplet and bubble formation) – to mimic blood flow in artery  On-chip total internal reflection (TIR) microscope  Point-of-Care Biosensor platform for screening/diagnosis of cancer & infectious diseases  Microscope on Chip: 3D ultrasound system, CMOS imager near-field System Formation of hydrogel plug Transformation from plug to spherical droplet Lab on Chip (Nano-Droplet & Bubble Formation) Inlet Outlet nanochannel microchannel + Optofluidic channels CMOS Imager

14. Major Laboratory Facilities Cell Culture Room Research inverted microscope, Incubator, Centrifuge, Water bath, Ultrapure water system, Ultralow (-80o) freezer, Cryogenic tank Other Equipments Ultrasound X-Y-Z scanning system, Sonix RP ultrasound system, Medelec Profile EEG system, Biopac, NORAXON EMG system, Desktop MRI scanning system. Biochemical Room Chemical cabinet, Chemical benches, Chemical hood, Universal laser cutting system Dark Room Optical tables, Lasers, Supercontinuum light source

15. Thanks! Join this programme to become a leader in healthcare innovation … … and improve the quality of life of many patients! We welcome your ideas! Professors will soon upload projects.

16. EE3080 Design and Innovation Project Programme: Electromedical Technologies Coordinator: Asst. Prof. Justin Dauwels jdauwels@ntu.edu.sg School of Electrical and Electronic Engineering Nanyang Technological University