Presentation is loading. Please wait.

Presentation is loading. Please wait.

Graver Technologies 200 Lake Drive, Glasgow, DE 19702 Liquid Filter Products Applications Training.

Similar presentations


Presentation on theme: "Graver Technologies 200 Lake Drive, Glasgow, DE 19702 Liquid Filter Products Applications Training."— Presentation transcript:

1 Graver Technologies 200 Lake Drive, Glasgow, DE Liquid Filter Products Applications Training

2 Graver Technologies 200 Lake Drive, Glasgow, DE Beverage Applications Prefiltration – Facility Water – Compressed Gas – Steam – Detergents / Cleaning Solvents – DE Trap – Polishing Prior To Bottling Final Filtration – Facility Water – Facility Gas – Tank Venting – Chill Haze Removal

3 Graver Technologies 200 Lake Drive, Glasgow, DE Beer Filtration Aging Tank Diatomaceous Earth Filter F1 Holding Tank Raw Beer Sheet Filter F1 F3 OR F1 Keg Filling - Bottle Filling - Can Filling F3 F2

4 Graver Technologies 200 Lake Drive, Glasgow, DE Beer Filtration

5 Graver Technologies 200 Lake Drive, Glasgow, DE Wine Filtration Crushed Grapes Fining Stage Aging Tank Sheet Filter Holding Tank F1 F2 F3 Bottling Tank Fermentation Filling Station To Wine Cooler Processing Wine

6 Graver Technologies 200 Lake Drive, Glasgow, DE Wine Filtration

7 Graver Technologies 200 Lake Drive, Glasgow, DE Wine Cooler Filtration Bulk Wine Storage Tank F1 Blend Tank F2F3 Filling Station Carbonator Wine Cooler

8 Graver Technologies 200 Lake Drive, Glasgow, DE Wine Cooler Filtration

9 Graver Technologies 200 Lake Drive, Glasgow, DE Food and Beverage Industry Heating or Cooling Sanitize Rinse Product Formulation F1 F3F2 F5F4 Process Water Process Equipment CIP (Clean In Place) Process Water

10 Graver Technologies 200 Lake Drive, Glasgow, DE Food and Beverage Industry Process Water

11 Graver Technologies 200 Lake Drive, Glasgow, DE Bio-processing of Food Products Steam F1 Seed Fermenter Compressed Air F5 F2F3 F4 Harvest Vessel F11F10 F9 F7F6 F8 Ammonia pH Adjust Final Product Purification Fermenter ( Production) Nutrients or Make-up water

12 Graver Technologies 200 Lake Drive, Glasgow, DE Bio-processing of Food Products

13 Graver Technologies 200 Lake Drive, Glasgow, DE Soft Drink Filtration F2 Corn Syrup F1 F3 F4 F5 Container Wash Filling Station Storage Tank Flavor Water Blending Tank

14 Graver Technologies 200 Lake Drive, Glasgow, DE Soft Drink Filtration

15 Graver Technologies 200 Lake Drive, Glasgow, DE Bulk Chemical Distribution Systems (BCDS) Semiconductor Applications VLSI-GRADE BULK-CHEMICAL MANUFACTURERS F1 F2 TO CHEMICAL DELIVERY SYSTEMS

16 Graver Technologies 200 Lake Drive, Glasgow, DE Filtered Bulk Chemicals 55 Gallon Drums 55 Gallon Drums F4F3 IN-HOUSE “CHEM-MIX” AREAS PACKAGERS, BOTTLERS, SPECIALTY MIXERS F4 BOTTLES Semiconductor Applications Bulk Chemical Delivery

17 Graver Technologies 200 Lake Drive, Glasgow, DE Bulk Chemical Delivery

18 Graver Technologies 200 Lake Drive, Glasgow, DE Deionized Water (DIW and UPW) –Change-out cycle - 2 years –Most competition –Most price competitive Key Factors for Cold UPW –Resistivity rebound – rinse-up –TOC rebound gal. to reach 99% of feed values –Extractables –Retention –Flow rate vs ΔP Semiconductor Applications

19 Graver Technologies 200 Lake Drive, Glasgow, DE F1 Incoming Water RO Storage Tank Reverse Osmosis System Resin Bed Ion Exchangers F2 Storage Tank Polishing Bottles F2 UV Lights F4 F3 F5 Point-Of-Use Filters DI Water Filtration

20 Graver Technologies 200 Lake Drive, Glasgow, DE DI Water Filtration

21 Graver Technologies 200 Lake Drive, Glasgow, DE CMP (Chemical Mechanical Planarization) Slurry of abrasives for removing thin layers (angstrom) via both grinding and etching for presenting an extremely smooth & normal surface for photolithography Remove particulate while leaving abrasive components Customer objective: reduce scratches and increase yield$ Recommendations day & mixing tanks…. PMC >20 um global loop (recirc)…. PMC um –coarse rating results in removal of agglomerates without removal of abrasives Semiconductor Applications

22 Graver Technologies 200 Lake Drive, Glasgow, DE CMP oxide slurries for silica removal pH abrasive size um agglomerates form from exposure to air CMP metal slurries for metal removal pH 2-4 Tends to settle; requires fast recirc. to keep suspended agglomerates Semiconductor Applications CMP Slurries

23 Graver Technologies 200 Lake Drive, Glasgow, DE Chemicals Most common Photoresist strip Phosphoric acid RCA Etch (SC 1 and SC 2… contains 1/3 peroxide) Sulfuric acid (for making piranha in fab) Nitric acid Photoresists Developers Semiconductor Applications

24 Graver Technologies 200 Lake Drive, Glasgow, DE Most common HF and BOE NOE (contains ethylene glycol…correct for viscosity when sizing) Acetone Piranha Baths 98% sulfuric acid; 2% hydrogen peroxide 3 - 6% more aggressive than “neat” sulfuric For removing metal Recirculating Etch Baths Using various % HF acid (attacks silica incl. glass) and BOE...buffered oxide etch (93% ammonium fluoride & 7% HF acid) Semiconductor Applications Tools

25 Graver Technologies 200 Lake Drive, Glasgow, DE Bottled Chemicals F6 F5 F7 F6 F5 F8 Wafer Cleaning “Piranha” “RCA Clean” Primers e.g., HMDS Etchants Developers, Rinses, Solvents Strippers Acid Processing Equipment Wet Tool Benches

26 Graver Technologies 200 Lake Drive, Glasgow, DE Tool Filtration

27 Graver Technologies 200 Lake Drive, Glasgow, DE Pharmaceutical Applications Prefiltration Facility Water Compressed Gas Steam Solvents & Intermediates LVPs (those to be terminally sterilized) Vaccines Fermentation Broth Serum / Culture Media Diagnostic Reagents Cosmetics / Creams / Lotions Orals / Ophthalmics

28 Graver Technologies 200 Lake Drive, Glasgow, DE Pharmaceutical Applications Final Filtration Facility Water Facility Air & Gas SVPs/LVPs Serum / Culture Media Biologicals (aseptic processing) Fermentation Products Fermentation Feed Air

29 Graver Technologies 200 Lake Drive, Glasgow, DE F1 Pretreatment Ion Exchange F2 F4 F3 F5 DI Water Tank F4 Pump Distilled Water Tank Pump POINT OF USE F3 F6 Process Water System Schematic POINT OF USE F4 POINT OF USE Steam Generator The process water system produces sterile water that is used throughout the facility in the manufacture and testing of product, and in support of the plant.

30 Graver Technologies 200 Lake Drive, Glasgow, DE Process Water

31 Graver Technologies 200 Lake Drive, Glasgow, DE Fermentation F1 F4 F2 F3 F2 F5 INLET GAS SUPPLY Steam Coolant Fermentation Broth Fermentation Tank Additives Fermentation : Specific organisms are grown in culture vessels producing a byproduct which can be isolated from the fermentation broth (e.g., Citric acid, fructose, alcohol, or certain drugs)

32 Graver Technologies 200 Lake Drive, Glasgow, DE Fermentation

33 Graver Technologies 200 Lake Drive, Glasgow, DE Antibiotic Processing Antibiotics Compounds intended to kill off specific bacterial infections. Made naturally as by-products of fermentation by certain bacteria, molds, and fungal species (e.g., Penicillin is a by-product of the mold genus penicillium).

34 Graver Technologies 200 Lake Drive, Glasgow, DE Antibiotic Processing Seed Tank Fermentation Vessel F1 Bulk Clarification & Concentration F7 F6 F5 F4 F3 F2 HPLC Purification Crystallization F8 Coolant Solvent Precip’n Activated Carbon Ion Exchange Purification Depyrogenation Reconstitution Final Dosage Form Steam

35 Graver Technologies 200 Lake Drive, Glasgow, DE Antibiotic Processing

36 Graver Technologies 200 Lake Drive, Glasgow, DE Therapeutic Production Therapeutics (other than antibiotics) Manufactured through a fermentative process, whether occurring naturally (e.g., Taxol), or as by-products from culture in genetically engineered organisms (e.g., Insulin).

37 Graver Technologies 200 Lake Drive, Glasgow, DE Therapeutic Production F1 F5F4 F3F2 Fermentation Vessel F5 F4 F7 F6 Bulk Clarification Isolation / Purification Virus Removal Steam Coolant Fermentation Broth/ Culture Media Inlet Gas Supply Growth Additives / Water, Serum Final Product

38 Graver Technologies 200 Lake Drive, Glasgow, DE Therapeutic Production

39 Graver Technologies 200 Lake Drive, Glasgow, DE LVP/SVPs Large Volume Parenterals Generally fluid in nature Must be administered intravenously (e.g., TPA/TPN solutions, IV Bags). The filter is removes bacteria and any particulate that could block tiny blood vessels. Small Volume Parenterals Vials of liquid (usually fewer than 100 ml) or powder. The key to filtration is removal of bacteria and particulate impurities that could clog a blood vessel, or block the nozzle of a filling machine.

40 Graver Technologies 200 Lake Drive, Glasgow, DE LVPs F1 Storage Tank F3 F2 Depyrogenation Autoclave Parenteral Formulation QC Testing and Release

41 Graver Technologies 200 Lake Drive, Glasgow, DE LVPs

42 Graver Technologies 200 Lake Drive, Glasgow, DE SVPs Mix Tank F4 F1 F3 F2 Vial/Stopper Washer Filling Machine F5 Lyophilizer Parenteral Ingredients Air Supply Liquids Powders vials / stoppers

43 Graver Technologies 200 Lake Drive, Glasgow, DE SVPs

44 Graver Technologies 200 Lake Drive, Glasgow, DE Ophthalmic Solutions Ointments, drops and medications placed intraocular. Filtration makes these sterile and safe to use by removing bacteria and particulate impurities that might scratch the cornea, or cause other discomfort in the eye.

45 Graver Technologies 200 Lake Drive, Glasgow, DE Ophthalmic Solutions F5 F4F3 F2 Heated Holding Tank Pump Sterile Blending Tank Petrolatum Drug Additives Testing and Final Packaging System Schematic F1

46 Graver Technologies 200 Lake Drive, Glasgow, DE Ophthalmic Solutions

47 Graver Technologies 200 Lake Drive, Glasgow, DE Glossary of Terms Antibiotic – class of compounds derived synthetically or naturally that have bacteriacidal characteristics BOE – buffered oxide etch – etch chemical composed of ammonium fluoride and hydrofluoric acid CMP slurry – chemical mechanical polishing - Slurry of abrasives used to remove thin layers (angstrom) from a wafer via both grinding and etching. Fermentation - process of converting sugars to harvestable intermediate of end products such as alcohol, antibiotics, HF – hydrofluoric acid

48 Graver Technologies 200 Lake Drive, Glasgow, DE Glossary of Terms LVP – Large volume parenteral – liquid intravenous solutions administered in doses of larger than 100ml NOE - etch chemical composed of ammonium fluoride and ethylene glycol Petrolatum – petroleum based “gel” Piranha - etch chemical composed of hydrogen peroxide and sulfuric acid.

49 Graver Technologies 200 Lake Drive, Glasgow, DE Glossary of Terms Pyrogen –portion of the cell wall of a gram negative bacterial resulting in a pyrogenic (fever) reaction in mammalian systems RCA Etch – etch chemical composed of either hydrogen peroxide and ammonium hydroxide (SC1) or hydrogen peroxide and hydrochloric acid (SC2) SVP – small volume parenteral – liquids administered intravenously in volumes of less than 100ml VLSI Grade- purity grade of semiconductor chemicals – derived from Very Large Scale Integration


Download ppt "Graver Technologies 200 Lake Drive, Glasgow, DE 19702 Liquid Filter Products Applications Training."

Similar presentations


Ads by Google