3. Scientific Coordinators (SCs) Jens Overgaard and Cai Grau International Advisory Committee (IAC) Professor Harry Bartelink, NKI-AVL, Amsterdam Professor Michael Baumann, Universitätsklinikum Dresden Professor Bengt Glimelius, University Hospital Uppsala Professor Clifton C. Ling, Memorial Sloan-Kettering Cancer Center, NY, USA Professor Philip Poortmans, Tilburg, The Netherlands Education Committee (EC) Danish Graduate School in Clinical Oncology (DAFKO) WP1 Individual radiosensitivity Jan Alsner WP2 Bioimaging Marianne Nordsmark WP3 Image management Thomas Sangild Sørensen WP4 Functional imaging Leif Østergaard WP5 Organ motion Carsten Brink WP6 Adaptive IG-IMRT Stine Korreman WP7 Implantable markers for IGRT Jesper Carl WP8 Dose verification Claus Andersen IP1 Head and neck Jens Overgaard IP2 Lung Olfred Hansen IP3a Breast Birgitte Offersen IP4 Lymphoma Lena Specht IP5 Upper GI Marianne Nordsmark IP6 Liver metastasis Morten Høyer IP7 Bladder Morten Høyer IP8 Prostate Peter Meidahl Petersen IP9 Rectum Anders Jakobsen IP10 Rectum (contact therapy) Jacob Lindegaard IP11 Cervix (hypoxia) Svend Aage Engelholm IP12 Cervix (MRI / brachy) Jacob Lindegaard IP13 Anal Hanne Havsteen Project Coordinating Committee (PCC) Jens Overgaard (SC, IP1), Cai Grau (SC) Jan Alsner (WP1), Marianne Nordsmark (WP2, IP5), Thomas Sangild Sørensen (WP3), Leif Østergaard (WP4), Carsten Brink (WP5), Stine Korreman (WP6), Jesper Carl (WP7), Claus Andersen (WP8), Ivan Vogelius (WP9), Olfred Hansen (IP2), Birgitte Offersen (IP3a), Marie Overgaard (IP3b), Lena Specht (IP4), Morten Høyer (IP6, IP7), Peter Meidahl Petersen (IP8), Anders Jacobsen (IP9), Jacob Lindegaard (IP10, IP12), Svend Aage Engelholm (IP11, RH), Hanne Havsteen (IP13), Ole Steen Nielsen (AAR), Lisbeth Juhler Andersen (AAL), Bente Sørensen (VS), Niels Holm (OUH), Lise Sengeløv (HH), Hans von der Maase (RH) WP9 Tools for dose plan evaluation and reporting Ivan Vogelius Administrative Coordinator (AC) Forskningsstøtteenheden Aarhus University Hospital IP3b Breast Marie Overgaard Collaborating international institutions and partners University of Wisconsin School of Medicine and Public Health (UWSMPH) Søren Bentzen Princess Margaret Hospital, University of Toronto (PMH) Rob Bristow Haukeland University Hospital, Bergen (HUH) Olav Dahl The Norwegian Radium Hospital, Oslo (DNR) Anne-Lise Børresen-Dale, Dag Rune Olsen Stanford University (SU) Amato Giaccia, Paul Keall Heidelberg (DKFZ) Oliver Jäkel Radboud University Nijmegen Medical Center (RU-NMC) Bert van der Kogel University of Maastricht (MAASTRO) Philippe Lambin Medical University of Vienna (MUV) Richard Pötter NKI-AVL, Amsterdam (NKI) Marcel Verheij

4. Work Packages laboratory-based translational research necessary methods will be developed toolbox for the tools to be applied in the clinical implementation WP1 Individual radiosensitivity Jan Alsner WP2 Bioimaging Marianne Nordsmark WP3 Image management Thomas Sangild Sørensen WP4 Functional imaging Leif Østergaard WP5 Organ motion Carsten Brink WP6 Adaptive IG-IMRT Stine Korreman WP7 Implantable markers for IGRT Jesper Carl WP8 Dose verification Claus Andersen WP9 Tools for dose plan evaluation and reporting Ivan Vogelius

5. Intervention Protocols clinical implementation of new methods in radiotherapy phase I, II, and III protocols protocols have been or will be designed with the necessary statistical power to secure a proper evaluation protocols will recruit patients from all institutions and thus exploit the benefit of a national centre IP1 Head and neck Jens Overgaard IP2 Lung Olfred Hansen IP3a Breast Birgitte Offersen IP4 Lymphoma Lena Specht IP5 Upper GI Marianne Nordsmark IP6 Liver metastasis Morten Høyer IP7 Bladder Morten Høyer IP8 Prostate Peter Meidahl Petersen IP9 Rectum Anders Jakobsen IP10 Rectum (contact therapy) Jacob Lindegaard IP11 Cervix (hypoxia) Svend Aage Engelholm IP12 Cervix (MRI / brachy) Jacob Lindegaard IP13 Anal Hanne Havsteen IP3b Breast Marie Overgaard