1. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Innovations in Aesthetic Medicine A Patient’s Guide to Restylane ®

2. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR What happens as we age? Young skin is smooth and elastic As we age, skin loses volume and wrinkles appear This is due, in part, to skin losing its ability to produce enough of a naturally occurring substance called hyaluronic acid (HA) Line Wrinkle Fold

3. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR What can be done? Dermal fillers with HA are an effective nonsurgical option –Fillers can fill in lines, restore lost volume, and soften facial folds –Fillers should be chosen by you and your doctor with care For illustration purposes only; not actual results.

4. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR What defines an ideal filler? Natural-looking results Long-lasting, but not permanent Quick and easy treatment Cost-effective Non-animal in origin No allergy testing required* Minimal side effects *Restylane contains traces of gram-positive bacterial proteins and is contraindicated for patients with allergies to such material.

5. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® is an innovative dermal filler Restylane is a crystal- clear, non-animal, biodegradable HA gel First non-animal HA dermal filler approved for cosmetic use in the United States Gel is injected into the skin using a very fine needle to minimize discomfort Note: Volume injected depends on patient, location, and degree of correction required. Photo courtesy of Q-Med.

6. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® is natural and safe Used by dermatologists and plastic surgeons worldwide since 1996 Contains HA, which is a natural part of human skin Free from animal proteins. This limits any risk of animal-based disease transmission or allergic reaction* Maintains an excellent safety profile –More than 1.5 million treatments worldwide Most clinical experience worldwide *Restylane contains traces of gram-positive bacterial proteins and is contraindicated for patients with allergies to such material.

7. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® is long-lasting, not permanent Restylane effects generally last for about six months Because the face changes with age, permanent fillers may not look good over time Unlike permanent dermal fillers, your future needs can be re-evaluated when the treatment wears off With Restylane, follow-up treatments can be performed at any time

8. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR How do other fillers compare? Collagen –Bovine collagen is derived from animals (cows) and requires an allergy test –Restylane ® lasts for about six months Other HA-based products –Restylane has the highest HA concentration available (20 mg/mL) –Free from animal proteins - this limits any risk of animal-based disease transmission or allergic reaction* *Restylane contains traces of gram-positive bacterial proteins and is contraindicated for patients with allergies to such material.

9. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR How does Botox ® Cosmetic differ? Restylane ® is a natural cosmetic filler and Botox Cosmetic is a drug that relaxes the underlying muscles that cause wrinkles Some physicians use Botox Cosmetic for the upper third of the face and Restylane for the lower third Patients have been very pleased after treatment with both products

10. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR What do Restylane ® treatments cost? Restylane is a customized treatment based on your specific needs, so the cost will vary from patient to patient In general, the cost of a treatment is comparable to the cost of similar procedures However, because Restylane is long-lasting, it may be more economical over time

11. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR What should be done before treatment? There are things you can do before being treated with Restylane ® to improve your experience and results –Avoid using St. John’s Wort, high doses of vitamin E supplements, aspirin, or nonsteroidal anti- inflammatory medications, such as ibuprofen, for one week prior to treatment because these may increase bruising or bleeding at the injection site –For patients prone to facial cold sores, treatment can cause a recurrence; a medication may be prescribed to reduce your risk

12. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Treatment: Getting the look you desire Restylane ® is injected directly into the skin using an ultra fine needle to minimize discomfort The procedure is short, simple, and convenient, and the results are nearly instantaneous

13. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Will I feel discomfort? Many patients experience little to no discomfort during treatment, but everyone is different and certain parts of the face are more sensitive After the procedure, many patients felt that the pain was not as bad as expected

14. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR How to increase comfort during treatment A topical cream applied half an hour before treatment An injection of anesthesia, usually needed only when treating the sensitive area around the mouth Ice, which can be applied at the time of injection

15. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Avoid touching the area for at least six hours Keep a low profile that day –Postpone social engagements for one to two days –Avoid alcohol and vigorous exercise After your treatment, you might have some redness or swelling. This will normally last less than seven days Cold compresses can be applied immediately after treatment to reduce swelling Next morning, the area can be gently washed and light makeup applied Sunbathing and cold outdoor activities should be avoided until any redness or swelling disappear. If you are pregnant, breastfeeding, or under 18, you shouldn't use Restylane ® What to do after treatment

16. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® Results

17. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® Results Creates volume in the skin to smooth wrinkles and folds Produces an instantaneous, long- lasting, natural-looking enhancement Effects generally last for about six months

18. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® Results BeforeAfter Individual results may vary. Treatment of smile lines with 1 mL syringes

19. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® Results BeforeAfter Individual results may vary. Treatment of smile lines with 1 mL syringes

20. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® Results BeforeAfter Individual results may vary. Treatment of smile lines with 1 mL syringes

21. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® Results BeforeAfter Individual results may vary. Treatment of smile lines with 1 mL syringes

22. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® Results BeforeAfter Individual results may vary. Treatment of smile lines with 1 mL syringes

23. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® Results BeforeAfter Individual results may vary. Treatment of smile lines with 1 mL syringes

24. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® Results BeforeAfter Individual results may vary. Treatment of smile lines with 1 mL syringes

25. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Restylane ® is redefining satisfaction Provides immediate, long-lasting results Effects generally last for about six months No allergy testing required* More than 1.5 million treatments worldwide Excellent safety profile A simple, convenient procedure Ask for Restylane by name! *Restylane contains traces of gram-positive bacterial proteins and is contraindicated for patients with allergies to such material.

26. Restylane and Restylane (stylized) are registered trademarks of HA North American Sales AB. © 2004-2005 Medicis Aesthetics Holdings Inc. RES04089AR Product Information Visit www.RestylaneUSA.com to register for exclusive offers and benefits! This site features –Restylane Rewards TM of up to $ 475 –Facts about Restylane ® –Demonstrations and videos –Newsletters –Before-and-after photos –Complete product and safety information Don’t miss out!