Presentation Overview Invenios Group From Lab to POC Challenges at creating advanced consumables ATB (True Room Temperature Bonding) Applications
Invenios Worldwide Santa Barbara, California, USA Langen (Hessen) Germany Eindhoven Netherlands
Health Tech Trends: from Lab to POC Laboratory: Large degree of freedom, versatile, high-end… Stationary, expensive, specialist-use..
Lab-On-a-Chip… Select necessary functionalities for test Shrink…in size …and in price! possible to scale down? absolutely necessary? combination possible? controllable -> pre-programmed! inputs and outputs? unambiguous interpretation of results! reproducible? mass-producible? low cost?
And if you do it right, you get a solution that is: Very portable! (true ‘Point-of-care’ solution) Cheap (uses less reagents, sample..) Fast Easy-to-use Safe …
Design & Construction of Consumables Base material: Paper: very cheap! Plastic: cheap, easy to process Glass: transparancy, low autofluorescence, thermally stable, resistant against solvents Silicon: very mature semiconductor processes and tools available Construction: depends on material(s) ideal situation: combine materials! application dictates formfactor…. the smaller, the better ! (cheaper, portable,..!) FOTURAN ® PSGC
Pre-loaded Consumables / Sensors Problem -Need to have locally coated/functionalised structures…but chip needs to be hermetically closed -Glueing introduces toxicity -Anodic Bonding and Diffusion Bonding are NOT options:
Ambient (Room) Temperature Bonding (patented) (->2) True Room temperature < 30 o C (->1) Two or more substrates (different CTEs possible!) Thin film blocking layer on interface No glue or high temperatures Appropriate wavelength laser Very locally created plasma, so bulk of the material stays at room temperature
Room Temperature Bonding - Characteristics High bond strength > strength of the base material Low temperatures, heat impacted zone < 1 µm of bond joint Possible to create electrical leads in the same process step Embed fluids or biomaterial/-coatings (Fibronectin, Poly-acrylamide gel, PFTE / Teflon,…) Seals hermetically and in a vacuum, inert gas or even under water, if required Scalable process, designed for operating in clean room production lines
What can you bond? The following substrates can be bonded together in any combination: Several types of Glasses Quartz/Fuzed Silica Sapphire Silicon Silicon Nitride Silicon Oxide Metals (Gold, Titanium,…) Several plastics