2 Presentation Overview Invenios GroupFrom Lab to POCChallenges at creating advanced consumablesATB (True Room Temperature Bonding)Applications
3 Invenios Worldwide Langen (Hessen) Germany Eindhoven Netherlands Santa Barbara,California, USA
4 Health Tech Trends: from Lab to POC Laboratory:Large degree of freedom, versatile, high-end…Stationary, expensive, specialist-use..
5 Lab-On-a-Chip… Select necessary functionalities for test Shrink…in size …and in price!possible to scale down?absolutely necessary?combination possible?controllable -> pre-programmed!inputs and outputs?unambiguous interpretation of results!reproducible?mass-producible?low cost?
7 And if you do it right, you get a solution that is: Very portable! (true ‘Point-of-care’ solution)Cheap (uses less reagents, sample..)FastEasy-to-useSafe…
8 Design & Construction of Consumables Base material:Paper: very cheap!Plastic: cheap, easy to processGlass: transparancy, low autofluorescence, thermally stable, resistant against solventsSilicon: very mature semiconductor processes and tools availableConstruction:depends on material(s)ideal situation: combine materials!application dictates formfactor…. the smaller, the better ! (cheaper, portable,..!)FOTURAN ® PSGC
9 Pre-loaded Consumables / Sensors ProblemNeed to have locally coated/functionalised structures…but chip needs to be hermetically closedGlueing introduces toxicityAnodic Bonding and Diffusion Bonding are NOT options:
10 Ambient (Room) Temperature Bonding (patented) (->2) True Room temperature < 30o C(->1) Two or more substrates (different CTEs possible!)Thin film blocking layer on interfaceNo glue or high temperaturesAppropriate wavelength laserVery locally created plasma, so bulk of the material stays at room temperature
11 Room Temperature Bonding - Characteristics High bond strength > strength of the base materialLow temperatures, heat impacted zone < 1 µm of bond jointPossible to create electrical leads in the same process stepEmbed fluids or biomaterial/-coatings (Fibronectin, Poly-acrylamide gel, PFTE / Teflon,…)Seals hermetically and in a vacuum, inert gas or even under water, if requiredScalable process, designed for operating in clean room production lines
12 What can you bond?The following substrates can be bonded together in any combination:Several types of GlassesQuartz/Fuzed SilicaSapphireSiliconSilicon NitrideSilicon OxideMetals (Gold, Titanium,…)Several plastics