Once the pathogen has been identified & antibiotic sensitivities determined, the most appropriate drug or drugs should be selected. For most gram-negative enteric bacteria, Ampicillin & an Aminoglycoside or a 3rd-generation cephalosporin (cefotaxime or ceftazidime) should be used. Enterococci should be treated with both a penicillin (Ampicillin or piperacillin) & an aminoglycoside because the synergy of both drugs is needed. Ampicillin alone is adequate for L. monocytogenes, and penicillin suffices for GBS. Clindamycin or metronidazole is appropriate for anaerobic infections
Is determined by pattern of disease and the organisms that are common for the age of infant& the flora of the nursery. Duration of Rx; meningits(14—21days) Pneumonia(7—10)
Aggressive management of suspected maternal chorioamnionitis with antibiotic therapy during labor,along with rapid delivaryof the infant,reduces the risk of early Nnsepsis. Intrapartum chemoprophylaxsis reduced the vertical transmission of GBS.
That is unexpected by history and unexplained by a thorough postmortem examination,which includes a complete autopsy,investigation of the scene of death, and review of medical history.
Maternal ; Smoking,Drugs Nutritional deficiency Decreased age,education Single marital status IGR,increas parity Low socioeconomic status Infant; Age(2-4mo),PT,Male Pron sleep position Growth failure Recent(febrile) illness Soft bedding