2. Food and Drug Interactions
Khalid A. Al-Madani, MPH, DSc
Consultant In Clinical Nutrition & Vice Present
of Saudi Society for Food and Nutrition

7. Medications and Food Intake Drug Complications That
Alter Food Intake

8. and Food Intake (Conti.)
Medications
and Food Intake (Conti.)
Medication That Alter
Appetite

9. Diet-Drug Interactions on Nutrient Absorption
and Absorption
Medication Effects
on Nutrient Absorption

10. Diet-Drug Interactions and Absorption (Conti.)
Drug-nutrient binding

11. Diet-Drug Interactions and Absorption (Conti.)
Altered acidity in the
stomach

12. Diet-Drug Interactions and Absorption (Conti.)
Stomach Emptying Rate

13. Diet-Drug Interactions
and Metabolism
An increase leads to a decrease
in enzyme activity in drug concentration
and effect
AND
A decrease leads to an increase

14. Diet-Drug Interactions and Metabolism ( Conti.)

15. Diet-Drug Interactions and Metabolism ( Conti.)
A New Concern - Grapefruit
Can cause more of a drug to be absorbed from intestine – even toxic levels
May cause a drug not to work

16. Diet-Drug Interactions and Metabolism ( Conti.)

17. Diet-Drug Interactions and Metabolism ( Conti.)
Vitamin K and Warfarin
Keep intake of foods containing Vitamin K constant
Vitamin K is high in spinach, kale, cauliflower, broccoli and other leafy greens
Also don’t take Vitamin K
supplement

18. Diet-Drug Interactions
and Excretion
Medication Effects on
Nutrient Excretion

19. Diet-Drug Interactions
and Excretion ( Conti.)
Dietary Effects on
Medication Excretion

20. Diet-Drug Interactions
and Toxicity

21. Diet-Drug Interactions
and Toxicity ( Conti.)
MOA Inhibitors
No beer, red wine
No cheddar, brie, mozzarella cheese
No beef or chicken liver, cured meats, caviar or dried fish

22. Diet-Drug Interactions
and Toxicity ( Conti.)

23. Conclusion
Clinicians often overlook or fail to recognize diet-drug interactions, yet such interactions can raise health care costs and result in serious, and sometimes fatal, complications. With hundreds of diet-drug interactions known and more to be identified in the future, health care professionals must learn to take steps to prevent them.

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