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Food and Drug Interactions Khalid A. Al-Madani, MPH, DSc Consultant In Clinical Nutrition & Vice Present of Saudi Society for Food and Nutrition.

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Presentation on theme: "Food and Drug Interactions Khalid A. Al-Madani, MPH, DSc Consultant In Clinical Nutrition & Vice Present of Saudi Society for Food and Nutrition."— Presentation transcript:

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2 Food and Drug Interactions Khalid A. Al-Madani, MPH, DSc Consultant In Clinical Nutrition & Vice Present of Saudi Society for Food and Nutrition

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7 Medications and Food Intake Drug Complications That Alter Food Intake

8 Medications and Food Intake (Conti.) Medication That Alter Appetite

9 Diet-Drug Interactions and Absorption Medication Effects on Nutrient Absorption

10 Drug-nutrient binding Diet-Drug Interactions and Absorption (Conti.)

11 Diet-Drug Interactions and Absorption (Conti.) Altered acidity in the stomach

12 Stomach Emptying Rate Diet-Drug Interactions and Absorption (Conti.)

13 Diet-Drug Interactions and Metabolism An increase leads to a decrease in enzyme activityin drug concentration and effect AND A decrease leads to an increase in enzyme activityin drug concentration and effect

14 Diet-Drug Interactions and Metabolism ( Conti.)

15 Diet-Drug Interactions and Metabolism ( Conti.) A New Concern - Grapefruit Can cause more of a drug to be absorbed from intestine – even toxic levels Can cause more of a drug to be absorbed from intestine – even toxic levels May cause a drug not to work May cause a drug not to work

16 Diet-Drug Interactions and Metabolism ( Conti.)

17 Diet-Drug Interactions and Metabolism ( Conti.) Vitamin K and Warfarin Keep intake of foods containing Vitamin K constant Keep intake of foods containing Vitamin K constant Vitamin K is high in spinach, kale, cauliflower, broccoli and other leafy greens Vitamin K is high in spinach, kale, cauliflower, broccoli and other leafy greens Also dont take Vitamin K Also dont take Vitamin K supplement supplement

18 Diet-Drug Interactions and Excretion Medication Effects on Nutrient Excretion

19 Diet-Drug Interactions and Excretion ( Conti.) Dietary Effects on Medication Excretion

20 Diet-Drug Interactions and Toxicity

21 Diet-Drug Interactions and Toxicity ( Conti.) MOA Inhibitors No beer, red wine No beer, red wine No cheddar, brie, mozzarella cheese No cheddar, brie, mozzarella cheese No beef or chicken liver, cured meats, caviar or dried fish No beef or chicken liver, cured meats, caviar or dried fish

22 Diet-Drug Interactions and Toxicity ( Conti.)

23 Conclusion Clinicians often overlook or fail to recognize diet-drug interactions, yet such interactions can raise health care costs and result in serious, and sometimes fatal, complications. With hundreds of diet-drug interactions known and more to be identified in the future, health care professionals must learn to take steps to prevent them.

24 THANK YOU FORLISTENING


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