Presentation on theme: "Jürgen Barth, Essen1 Uridine 10% hand-foot- ointment and adhesive-paste For the treatment of the hand-foot syndrome (PPE) and mucositis induced by of 5-FU."— Presentation transcript:
Jürgen Barth, Essen1 Uridine 10% hand-foot- ointment and adhesive-paste For the treatment of the hand-foot syndrome (PPE) and mucositis induced by of 5-FU and its oral derivates (Capecitabine, UFT)
Jürgen Barth, Essen2 The (short) story of how it came into being Side effects of 5-FU (& derivates): PPE Mucositis Pharmacological considerations about an „antidot“ in the 90ies Various substances seemed to be a possibility Thymine Thymidine Uracil Uridine 2‘-Deoxyuridine
Jürgen Barth, Essen3 The (short) story of how it came into being Decision: Uridine Development of a formula in the Dept.of Pharmacy, Essen “Clinical experience“ after a short time: IT WORKS Since then: an “in-house-speciality” Useful after extravasation or skin contamination Uridin-Hand-Fußsalbe und Uridin-Haftpaste als effektive Antidota nach akzidenteller Hautkontamination mit 5-Fluorouracil – ein Fallbericht Krankenhauspharmazie 2000; 21: Evidence based data concerning efficacy (by systematical inquiry): NONE
Jürgen Barth, Essen4 The formulae Uridine 10% hand- & foot ointment Uridin10 g Propylene glycolq.s. Basiscreme DACad 100 g Uridine 10% adhesive-paste Uridin1 g Subliquid paraffin6,65 g Carbopol 9342,35 g Spearmint oil 1 gtt. -Uridine is mixed with a small amount of propylene glycol. -This dispersion is then added to DAC basic cream. -DAC basic cream is monographed in the Deutscher Arzneimittel Codex (German drug codex), representing a collection of drug monographs besides the European and German Pharmacopoeia. -DAC basic cream is an amphiphile nonionic cream. -Uridine is added to a hydrophobic adhesive-paste composed of subliquid paraffin and Carbopole 974P, a type of polyacrylic acid. -The paste is flavoured with spearmint oil.
Jürgen Barth, Essen5 Aim of an ESOP study Systematical data collection to evaluate the efficacy of the ointment and –if possible- the adhesive ( mucous membrane) paste How? ESOP will make the formulae (instructions how to prepare a drug) available to any interested pharmacist who feels able to prepare these medication and offer it to physicians who treat patients with 5-FU, Capecitabine or UFT Data will be collected by the individual pharmacist Summary and evaluation by ESOP
Jürgen Barth, Essen6 ESOP study Evaluation sheet (and this presentation) will be the ESOP homepage:
Jürgen Barth, Essen7 ESOP study Evaluation sheet