Presentation on theme: "Jürgen Barth, Essen1 Uridine 10% hand-foot- ointment and adhesive-paste For the treatment of the hand-foot syndrome (PPE) and mucositis induced by of 5-FU."— Presentation transcript:
Jürgen Barth, Essen1 Uridine 10% hand-foot- ointment and adhesive-paste For the treatment of the hand-foot syndrome (PPE) and mucositis induced by of 5-FU and its oral derivates (Capecitabine, UFT)
Jürgen Barth, Essen2 The (short) story of how it came into being Side effects of 5-FU (& derivates): PPE Mucositis Pharmacological considerations about an „antidot“ in the 90ies Various substances seemed to be a possibility Thymine Thymidine Uracil Uridine 2‘-Deoxyuridine
Jürgen Barth, Essen3 The (short) story of how it came into being Decision: Uridine Development of a formula in the Dept.of Pharmacy, Essen “Clinical experience“ after a short time: IT WORKS Since then: an “in-house-speciality” Useful after extravasation or skin contamination Uridin-Hand-Fußsalbe und Uridin-Haftpaste als effektive Antidota nach akzidenteller Hautkontamination mit 5-Fluorouracil – ein Fallbericht Krankenhauspharmazie 2000; 21: 625-628 Evidence based data concerning efficacy (by systematical inquiry): NONE
Jürgen Barth, Essen4 The formulae Uridine 10% hand- & foot ointment Uridin10 g Propylene glycolq.s. Basiscreme DACad 100 g Uridine 10% adhesive-paste Uridin1 g Subliquid paraffin6,65 g Carbopol 9342,35 g Spearmint oil 1 gtt. -Uridine is mixed with a small amount of propylene glycol. -This dispersion is then added to DAC basic cream. -DAC basic cream is monographed in the Deutscher Arzneimittel Codex (German drug codex), representing a collection of drug monographs besides the European and German Pharmacopoeia. -DAC basic cream is an amphiphile nonionic cream. -Uridine is added to a hydrophobic adhesive-paste composed of subliquid paraffin and Carbopole 974P, a type of polyacrylic acid. -The paste is flavoured with spearmint oil.
Jürgen Barth, Essen5 Aim of an ESOP study Systematical data collection to evaluate the efficacy of the ointment and –if possible- the adhesive ( mucous membrane) paste How? ESOP will make the formulae (instructions how to prepare a drug) available to any interested pharmacist who feels able to prepare these medication and offer it to physicians who treat patients with 5-FU, Capecitabine or UFT Data will be collected by the individual pharmacist Summary and evaluation by ESOP
Jürgen Barth, Essen6 ESOP study Evaluation sheet (and this presentation) will be downloadable @ the ESOP homepage: http://www.esop.li/
Jürgen Barth, Essen7 ESOP study Evaluation sheet http://www.esop.li/