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Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. CHAPTER 6 Gene Expression: Translation Peter J. Russell.

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Presentation on theme: "Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. CHAPTER 6 Gene Expression: Translation Peter J. Russell."— Presentation transcript:

1 Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. CHAPTER 6 Gene Expression: Translation Peter J. Russell

2 Translation and the genetic code

3 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.17 Diagram of a polysome, a number of ribosomes each translating the same mRNA sequentially Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings.

4 Fig. 6.3 Mechanism for peptide bond formation between the carboxyl group of one amino acid and the amino group of another amino acid

5 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.4 Four levels of protein structure

6 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.6 Reversion of a deletion frameshift mutation by a nearby addition mutation

7 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.7 Hypothetical example showing how three nearby + (addition) mutations restore the reading frame, giving normal or near-normal function

8 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.8 The genetic code

9 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.9 Example of base-pairing wobble

10 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.11 Molecular details of the attachment of an amino acid to a tRNA molecule

11 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.10 Charging of a tRNA molecule by aminoacyl-tRNA synthetase to produce an aminoacyl-tRNA (charged tRNA)

12 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.12 Initiation of protein synthesis in prokaryotes

13 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.14 Sequences involved in the binding of ribosomes to the mRNA in the initiation of protein synthesis in prokaryotes Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings.

14 Fig. 6.16 The formation of a peptide bond between the first two amino acids of a polypeptide chain is catalyzed on the ribosome by peptidyl transferase Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings.

15 Fig. 6.15 Elongation stage of translation in prokaryotes

16 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.18 Termination of translation Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings.

17 Fig. 6.19 Movement of secretory proteins through the cell membrane system Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings.

18 Fig. 6.20 Model for the translocation of proteins into the endoplasmic reticulum in eukaryotes Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings.


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