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Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. CHAPTER 6 Gene Expression: Translation Peter J. Russell.

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Presentation on theme: "Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. CHAPTER 6 Gene Expression: Translation Peter J. Russell."— Presentation transcript:

1 Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. CHAPTER 6 Gene Expression: Translation Peter J. Russell

2 Translation and the genetic code

3 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig Diagram of a polysome, a number of ribosomes each translating the same mRNA sequentially Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings.

4 Fig. 6.3 Mechanism for peptide bond formation between the carboxyl group of one amino acid and the amino group of another amino acid

5 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.4 Four levels of protein structure

6 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.6 Reversion of a deletion frameshift mutation by a nearby addition mutation

7 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.7 Hypothetical example showing how three nearby + (addition) mutations restore the reading frame, giving normal or near-normal function

8 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.8 The genetic code

9 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig. 6.9 Example of base-pairing wobble

10 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig Molecular details of the attachment of an amino acid to a tRNA molecule

11 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig Charging of a tRNA molecule by aminoacyl-tRNA synthetase to produce an aminoacyl-tRNA (charged tRNA)

12 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig Initiation of protein synthesis in prokaryotes

13 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig Sequences involved in the binding of ribosomes to the mRNA in the initiation of protein synthesis in prokaryotes Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings.

14 Fig The formation of a peptide bond between the first two amino acids of a polypeptide chain is catalyzed on the ribosome by peptidyl transferase Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings.

15 Fig Elongation stage of translation in prokaryotes

16 Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings. Fig Termination of translation Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings.

17 Fig Movement of secretory proteins through the cell membrane system Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings.

18 Fig Model for the translocation of proteins into the endoplasmic reticulum in eukaryotes Peter J. Russell, iGenetics: Copyright © Pearson Education, Inc., publishing as Benjamin Cummings.


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