1. Symposium for Patients & Caregivers

2. Cognitive Impact of HH (and what can we do about it) Jennifer V. Wethe, Ph.D.* Clinical Neuropsychologist Hook Rehabilitation Outpatient Services Community Hospital Network Indianapolis, Indiana *Formerly with Barrow Neurological Institute/SJHMC

3. Outline Cognitive functioning in individuals with epilepsy and HH Cognitive outcome of neurosurgical interventions for HH Interventions for cognitive difficulties Working with schools

4. Cognitive Functioning

5. Cognitive Functioning in Epilepsy Epilepsy is associated with impaired/abnormal cognitive functioning High rates of mental retardation (MR) in patients with childhood-onset epilepsy Increased risk of MR if intractible seizures with onset during the first 2 years of life, especially if daily seizures Refractory epilepsy is associated with cognitive decline, particularly in children Bjornes et al., (2001), Dodrill (2004), Herman & Seidenberg (2007), Vasoncellos et al., 2001

6. Clinical Syndrome of HH with Epilepsy Neuropsychological/Behavioral Features Wide range of intellectual functioning Near normal Declining after a period of relatively normal development Mental Retardation & clear developmental delay Behavioral Disturbance Rage reactions, irritability Impulse control, ODD, CD, attention/ADHD, aggression, anxiety & compulsive behavior, depression, mood instability Autistic or Asperger’s-like interpersonal skills & affect Weissenberger et al, 2001; Prigatano et al, 2006; Veendrick-Meekes (2007) Not all elements occur in every patient

7. Cognitive Functioning in HH Patients Berkovic et al 1988 4 pediatric/adult patients with follow-up All had cognitive deficits with 3 showing deterioration over time Frattali et al 2001 All 8 children displayed cognitive deficits, ranging from mild to severe Gelastic/CPS seizure frequency and severity correlated with broad cognitive ability scores Relative weakness in long term retrieval and information processing speed Relative strength in visual processing

8. Cognitive Functioning in HH Patients Harvey et al 2003 29 patients aged 4-23 72.4% of patients in series had intellectual disability Mullatti 2003 14 patients whose HH was discovered at age 16 or later. No or minimal seizure difficulties Compared to series of younger patients: Fewer “learning difficulties,” although 2/14 had moderate to severe learning difficulties and were in residential care; 6 had “mild” learning difficulties More patients with “normal” IQ, although they may not show typical patterns of cognitive functioning Fewer behavior problems

9. Cognitive Functioning in HH Patients Quiske et al 2006 13 juvenile and adult patients IQ ranged from moderate MR to good 54% had below average IQ Memory impaired in most patients-both verbal & visual Impairments in attention, executive systems functioning and visuospatial abilities was common Regis et al 2006 27 patients aged 3 to 50 Mental retardation in 30% and low average IQ in an additional 26% of patients Difficulties with sustained attention, impulsivity, disinhibition

10. Cognitive Functioning in HH Prigatano et al 2008 49 HH patients aged 5-55. Three patterns were identified Pattern 1: ( “ near normal ” ) average or above average IQ with no significant verbal-nonverbal split (17 patients; 35%) Pattern 2: ( “ transitional ” ) Notable disparity between verbal and visuospatial skills -- One at least 1 SD below mean with other score normal (9 patients; 18%) Pattern 3a: Mentally retarded, but testable (16 patients; 33%)) Pattern 3b: Mentally retarded, untestable (7 patients; 14%) Wethe, Prigatano et al 32 pediatric & adult patients evaluated prior to surgery Mean pre-surgical IQ in the low average (mildly impaired) range Mildly to moderately impaired new learning and memory Mildly to moderately impaired speed of processing Severely impaired mental flexibility (e.g., multi-tasking) Low average basic language and motor abilities

11. Cognitive Functioning in HH: (Pre-surgical) Summary Highly variable, ranging from essentially or near normal to profoundly impaired High proportion of mental retardation Abnormalities in cognitive functioning even in patients with “normal” IQ Attention, memory, visuospatial skills, speed, mental flexibility Individuals with later onset of seizure disorder (e.g., late adolescent or adulthood) and less disabling seizures tend to have better cognitive functioning

12. Surgical Outcome

13. Surgery Surgical advances in the treatment of HH have been shown to improve seizure outcome, but little is known about cognitive and behavioral outcome. HH is located deep within the brain and neuroanatomical structures important for memory may be placed at risk by the surgical approach.

14. Outcome of GK Surgery Regis et al 2006 27 patients at least 3 years post GKS 59% had “dramatic behavioral and cognitive improvement” and many had “developmental learning acceleration at school” but details not provided No complaints of worsening cognitive abilities or short- term memory complaint Mathieu et al 2010 9 patients aged 12-57 Quality of life and verbal memory improved

15. Outcome of Interstitial Radiotherapy Quiske et al 2007 14 adolescent and adult patients did not demonstrate any significant cognitive changes 3 months following interstitial radiotherapy

16. Outcome of Radiofrequency Thermocoagulation Kameyama et al 2009 25 patients aged 2-36 years 56% MR pre-surgery Intellectual improvement and resolution of behavior disorder

17. Outcome of TC surgery Harvey et al 2003 29 patients aged 4-23 14 patients had early short-term memory impairment. This persisted in 4 patients, 2 of which had undergone prior surgery Ng et al 2006 26 patients (no formal post-op testing) Subjective report of improved cognitive functioning in 65% of patients Transient post-operative memory impairment in 58%, persisted in 8% (2 patients) Anderson and Rosenfeld 2010 4 of the patients Improvement in perceptual/visuospatial functioning ¾ patients showed decline in memory

18. Outcome of TC and Endoscopic Resection: Barrow Series Pediatric and adult patients (3-39 yo; mean 12 yo) with refractory epilepsy 11 TC; 20 Endoscopic, 1 combined Mostly sessile Type II HH (within 3 rd ventricle) Early onset of epilepsy (most within 1 st months, all by age 5) Mean follow-up interval was nearly 2 years (range 5 – 47 months)

19. Raw or RangePercentages Demographics Mean (SD) Age at surgery (years)12.2 (7.0)3.3-39.3 Mos. btwn surgery & post-eval23.4 (12.0)5.1-47.2 Sex (male/female)20/1262.5/37.5 Handedness (right/left)22/1068.8/31.3 Precocious Puberty (Yes/No)9/23 28.1/71.9 HH Characteristics Pre-surgery Type (I/II/III/IV)1/24/4/33.1/75/12.5/9.4 Side of attachment (L/R/b)13/10/940.6/31.3/28.1 Pre-surgery Volume (cm3)4.45 (8.62)0.13-38.25 Seizure Characteristics Pre-surgery Age of onset (months)10.0 (15.1)1-60 Duration of epilepsy (months)136.3 (83.7)38-459 Seizure types (Gel only / multiple)6/2618.8/81.3 # of AEDs2.1 (0.76)1-4 Surgery Characteristics TC/Endoscopic/Combined11/20/134.4/62.5/3.1 % Resection83.7 (18.0)40-100 Thalamic Infarct 618.8 HH-NBOS Demographic & Clinical Characteristics

20. HH-NBOS Methods Pre and Post Assessment Measures Cognitive Screening BNIS or BNIS-C Intelligence Testing WAIS-III, WISC-III/IV, WPPSI-III Processing Speed Digit Symbol-Coding TMT Attention Digit Span Language Animal Fluency Memory RAVLT, CVLT-C BVMT-R Motor Halstead FTT Behavior CBCL

21. Outcome of TC and Endoscopic Surgery: Barrow Series 68.8% were seizure free at post-op assessment Patients were taking significantly fewer AEDs with 25+% not taking any AEDs Seizure freedom not necessary for cognitive gains

22. Cognitive Outcome of TC and Endoscopic Surgery: Barrow Series Performance on key and summary measures of intellectual functioning was improved FSIQ (12): 83  91.3 (Range -1 to 18) Performance on measures of attention and speed was improved No clear pattern for memory outcome (no overall decline) List Learning (17): 32.2  29.9 (Range -29 to 28) List delayed recall (14): 30.4  24.4 (Range -25 to 17) Trend toward decline on delayed verbal recall (n.s.) Some patients improved their memory performance while others clearly declined Patients with MRI Type III HH may be at greater risk of memory decline than patients with MRI Type II HH Verbal Fluency and nondominant hand finger tapping improved

23. Outcome of TC and Endoscopic Surgery: Barrow Series Younger patients and those with shorter duration of epilepsy were more likely to improve their intellectual functioning Patients with mental retardation at pre-surgery were more likely to have improved their intellectual functioning post-surgery Lower intellectual functioning and shorter duration of epilepsy at time of surgery was associated greater gains in intellectual functioning at post-surgical follow-up Complete seizure cessation not necessary for cognitive gains

24. Cognitive Outcome Post Neurosurgical Intervention: Key Points HH with refractory epilepsy is associated with cognitive decline (epileptic encephalopathy). Successful neurosurgical intervention can halt and even reverse the cognitive and behavioral decline. Complete seizure cessation may not be necessary for improvements to be observed. Temporary and permanent surgical complications are a risk with the invasive approaches and may negatively impact cognitive functioning (e.g., memory is an area of particular risk, although some patients experience improved memory functioning with successful surgery) Early intervention is important. Greatest gains with shortest duration of epilepsy.

25. Interventions

26. Professional Assistance Cognitive Rehabilitation Speech therapy—address cognitive skills (e.g., attention, memory, problem solving) and compensations Occupational therapy—Address activities of daily living, cognitive skills-particularly as they relate to ADLs, and compensations Neuropsychology Tutoring and special education assistance

27. Learning and Memory Types of long term memory Episodic Semantic – knowledge base Procedural Stages of learning and memory Attention Encoding - learning Storage – memory/retention Retrieval – use what has been learned; recall, performance

28. Strategies for Severe Memory Impairment All these techniques rely on or can be used with errorless learning. They are used with specific tasks and have poor generalization to other tasks. Errorless learning “You teacher’s name is ____. What is your teacher’s name?” “A verb is an action word. What is a verb?” Spaced retrieval Errorless learning combined with asking the individual to recall information over progressively longer intervals (e.g., Immediate, 15 sec., 30 sec., 1 min., …days) Chaining—Train individual to perform sequence of steps via procedural memory Each step serves as the cue to perform the next step. Errorless learning is used. Complex task broken down into series of discrete steps Train step 1. Then train step 1 with step 2, and so on. May be helpful for daily routines. E.g., brushing teeth, bathing, bedtime routine Haskins et al (2011)

29. Strategies for (Mild) Learning & Memory Problems Mnemonics Association techniques Visual – Verbal Association or Schematics Visual Peg Method, Method of Loci Organization and Elaboration techniques First letter mnemonics (e.g., ROY G BIV- ex. of chunking as well) PQRST (Preview, Question, Read, State, Test) – Good for students Use of humor or storytelling Haskins et al (2011)

30. General Strategies to Facilitate Learning (and Memory) Make it an active process Take notes, Organize the information Use multiple modalities Visualize—drawing, mental imagery Make meaningful, personalize Link to information already known Input  Output Frequent review and rehearsal Short repeated practice; build knowledge base even beyond the point of mastery – greatly increases speed of processing

31. General Strategies to Facilitate Learning and Memory Studying helps recognition, testing helps recall (e.g., flash cards) Emotional enhancement Use advance organizers Context/state dependent learning—when possible learn, practice in the environment where information/skill will be needed. Healthy lifestyle Sleep Stress reduction Diet Exercise

32. Compensations / External Aids for Memory and other Deficits Must be highly individualized Examples Calendars/memory notebooks/assignment books Can be checked and signed off on my teachers and parents Schedules (pictoral or written) Procedural checklists Task checklists Electronic devices and reminders Organizers

33. Compensations / Interventions for Attention Deficits Reduce distractions Make sure you have the individual’s attention Keep instructions short, simple and concrete. One step at a time. Short practice/rehearsal sessions Consider training in attention and working memory (often need involvement of therapist/individual/coach) Attention process training CogMed Lumosity.com

34. Working with Schools

35. Education 504: Section 504 of the Rehabilitation Act of 1973 IDEA IEP: Individual Educational Plan 504 Plan

36. Section 504 of the Rehabilitation Act of 1973 Protect the rights of individuals with disabilities in programs and activities that receive federals funds… Physical or mental impairment that causes a substantial limitation on a major life activity Requires schools to provide a “free appropriate public education” to each qualified person with a disability An appropriate education could consist of education in regular classes, education in regular classes with the use of supplementary services, or special education and related services in separate classrooms for all or portions of the day. Special education may include specially designed instruction in classroom, at home, or in private or public institutions, and may be accompanied by related services as speech therapy, occupation therapy and physical therapy, and psychological counseling and medical diagnostic services necessary to the child Shepard, Leon, & Fowler (2009) www.acdl.com; www.ade.az.gov/esswww.acdl.comwww.ade.az.gov/ess

37. IDEA Individuals with Disabilities Education Act Free and appropriate education (FAPE) Child Find Special Education and related services tailored to child’s unique needs Prepare for further education, employment, and independent living

38. Eligibility Categories Autism (A) Emotional Disability (ED) Hearing Impairment (HI) Mental Retardation Multiple Disabilities (MD) Multiple Disabilities—Severe Sensory Impairment (MDSSI) Orthopedic Impairment (OI) Other Health Impairment (OHI) Specific Learning Disability (SLD) Speech Language Impairment (SLI) Traumatic Brain Injury (TBI) Vision Impairment (VI) Preschool Moderate Delay (PMD) Preschool Severe Delay (PSD) Preschool Speech/Language Delay (PSL)

39. IDEA / IEP Process Family can request an initial evaluation (in writing) Once the school district receives written parental consent, they have 60 days to complete the evaluation Can use outside sources of information Private school students: district in which the school is located is responsible for performing the evaluation, not the district of residence

40. IEP Describes how the school tailors education to meet child’s unique needs How the school will provide related services (e.g., ST, OT, PT, etc.) that are necessary for the child to benefit from special education

41. Who attends the IEP? Multidisciplinary Evaluation Team (MET) Parents Regular education teacher Special education teacher Representative of the public agency Someone who can interpret test results and explain the educational implications of tests If needed, additional individuals knowledgeable of the student Student, if appropriate for transition services

42. Considerations / Elements in the IEP Strengths Parent concerns Evaluation data Needs Special factors (e.g., behavior) English fluency Extended School Year (ESY) Other services Modifications Accommodations Placement decisions Regular classes Special classes Special school Home Hospital/institution Least restrictive environment (LRE)

43. To the extent possible, children with disabilities are educated with nondisabled children (mainstream) Use of supplementary aids and services to maintain placement in regular classroom

44. 504 Accommodation Plan Written plan listing the necessary accommodations to minimize the impact of impairment http://www.ade.az.gov/ess/

45. Accommodations Provisions made to allow a student to access and demonstrate learning. These do not substantially change the instructional level, the content, or the performance criteria. The changes are made to provide the student equal access to learning and equal opportunities to demonstrate knowledge. AZ Department of Education (2008) Examples of Accommodations: http://www.osepideasthatwork.org/parentkit/school_acc om_mods_eng.asp http://www.osepideasthatwork.org/parentkit/school_acc om_mods_eng.asp

46. Adaptations Changes made to the environment, curriculum, instruction, and/or assessment practices for a student to be a successful learner. Adaptations include accommodations and modifications. Adaptations are based on an individual student’s strengths and needs. AZ Department of Education (2008)

47. Modifications Substantial changes in what a student is expected to learn and to demonstrate. Changes may be made in the instructional level, the content or the performance criteria. Such changes are made to provide a student with meaningful and productive learning experiences, environments, and assessments based on individual needs and abilities. AZ Department of Education (2008)

48. Accommodation Examples Preferential seating Additional time Reduced distractions Lecture outlines; copies of notes Test format (font, recognition vs free response) Mode of responding

49. Other Adaptations to Consider Quality over quantity Open book, open note tests Intermediate goals for longer assignments Memory or assignment book checked by teachers Use of an aid Many children with HH have similarities to children ADHD or Autistic Spectrum disorder. Similar strategies may be useful.

50. Resources and References for Parents/Students http://idea.ed.gov/ Part B: Ages 3-21 Part C: Ages birth – 2 http://www.c-c-d.org/task_forces/education/IdeaUserGuide.pdf PACER Center (http://www.c-c- d.org/task_forces/education/IdeaUserGuide.pdf)http://www.c-c- d.org/task_forces/education/IdeaUserGuide.pdf FAPE (http://www.fape.org/)http://www.fape.org/ http://www.help4adhd.org/en/education/rights/idea Executive Skills in Children & Adolescents by Dawson & Guare Late, Lost, & Unprepared by Cooper-Kahn & Dietzel

51. A Special Thanks to our Sponsors Aesculap Barrow Neurological Institute @ St. Joseph’s Hospital Barrow Neurological Institute @ Phoenix Children’s Hospital Great Council for the Improved Hope for Hypothalamic Hamartoma Foundation KARL STORZ Endoskope