1. Salivary gland-embryology
口 腔 病 理 科
Salivary gland-embryology
唾液腺-胚胎學
陳玉昆副教授: 高雄醫學大學 口腔病理科
~2755

2. 學 習 目 標 參考資料 1. Origins of salivary gland 2. Stages of development
3. Differentiation of terminal tubule cells
4. Cleft formation during salivary gland branching
5. Factors affecting branching of salivary gland cell cords
6. Classification of salivary gland cell cords
7. Classification, innervation, anatomy of major salivary gland
8. Classification, anatomy of minor salivary gland
9. Ductal system - components, comparison, histology
10. Saliva – composition, function
參考資料
References
Avery JK. Oral development and histology. 2nd edition, Chapter 21, p
Avery JK. Oral histology-a clinical approach. 1st edition, Chapter 15, p
Berkovitz BK, Holland GR, Moxham BH. 2nd edition, p.215, 220
4. de Almeida PDV, et al.. Saliva Composition and Functions: A Comprehensive
Review. J Contemp Dent Pract :72-80
5. Kaohsiung Medical University, Oral Pathology Department

3. Origins of salivary gland
8th prenatal
week
6th prenatal
Minor gland: 12 prenatal weeks
Frontal section
through
developing face
Epithelial outgrowth of
buccal epithelium
invading the underlying
mesenchyme
Nasal
septum
Tongue
Parotid bud
Sublingual
bud
Submandular
7th prenatal
Ref: 1

4. Stages of development
Stage I
Bud formation
Ref: 1

5. Stages of development
Stage II
Cord growth
Ref: 1

6. Stages of development
Stage III
Branching
of cord
Ref: 1

7. Stages of development
Stage IV
Lobule formation
Ref: 1

8. Stages of development Stage V Canalization of cords to form ducts
Ref: 1

9. Stages of development
Lobule
of gland
Connective
tissue
septa
Ref: 2

10. Stages of development
Stage VI
Cytodifferentiation
Ref: 1

11. Differentiation of terminal
tubule cells
Terminal
tubule cell
Proacinar cell
Intercalated
duct cell
(Stem cell)
Acinar
cells

12. Factors affecting branching of salivary gland cell cords
Hyaluronidase
Collagen
Generalized cell
proliferation
No branching
Basal lamina
Branching
Digest the collagen
Ref: 1

13. Cleft formation during salivary gland branchingBM E
M = messenchyme
BM = basement membrane
E = epithelium
Type IV
Type III
Type I
Collagen Type
Ref: 1

14. of salivary gland cell cords
Classification
of salivary gland cell cords
Tubuloacinar
type
Exocrine -
duct system
for secretion
transportation
Tubular
Tubulo-
acinar
Branching
duct
Main duct
Grape-like
Ref: 1

15. of salivary gland cell cords
Classification
of salivary gland cell cords
Method of secretory
production
Discharge
Membrane
Secretory granule
Golgi
Merocrine
type
secretory
process
Ref: 1

16. Classification- major salivary gland
Size
Location
Capsule
(14-28g)
(7-8g)
(3g)
Parotid
gland
Subman-
dibular
Sublingual
Ref: 1

17. Anatomy - major salivary gland
Stensen’s duct
(7 cm long)
Warthin’s duct
(5 cm long)
Bartholin’s duct
(Rivinus’s ducts)
Ref: 2

18. Classification- major salivary gland Contribution of saliva
Type of
secretion
Contribution of saliva
Striated duct
intercalated duct %
Paro-
tid
gland %
Subman-
dibular
gland
Sublin-
gual
gland %
Refs: 1, 4

19. Classification - major salivary gland
Parotid gland
Sublingual
gland
Submandinular
Sympathetic
innervation
Parasympathetic innervation
Preganglionic
Postganglionic
Ref: 1

20. Innervation of salivary gland
Parotid
gland
Sublingual
Submandibular gland
Auriculotemporal n
Chorda
tympani
Otic
ganglion
Submandibular
Superior
cervical
salivary
nucleus
Inferior
Parasympathetic
VII IX
Sympathetic
Ref: 1

21. Anatomy- major salivary gland Facial nerve vs fetal parotid gland
Ref: 1

22. Classification- major salivary gland
Parotid gland
Submandinular
gland
Sublingual
Blood supply
Arterial
Venous
Ref: 1

23. Anatomy - minor salivary gland
Uncapsulated;
named by
location
Ref: 2

24. Classification- minor salivary gland
Name
Location
Type of secretion
Contribution
of saliva
: 5-10%
Ref: 1

25. Classification- minor salivary gland
A: Small serous glands of von Ebner empty into the base of trench
Taste buds
Circumvallate papillae in longitudinal A
Ref: 3

26. Ductal system Acinus Capsule Septa Lobe Secretory Units Intercalated
Striated
Excretory
Ducts
Ref: 3

27. Ductal system Intra-Lobular Inter-Lobular Ref: 3 Striated duct
Excretory
Serous cell
Serous
demilune
Mucous
acinus
cell
Intercalcated
Myoepithelial cell
Inter-Lobular
Ref: 3

28. Ductal system Oral cavity Excretory duct Interlobular duct system
Major salivary gland duct orifice
Oral epithelium
Interlobular
duct system
Intralobular
Excretory duct
Serous
acinus
Mucous
acinus
Mixed
acinus
Ref: 2

29. Comparison of ductal system
Relative ductal length
Parotid gland
Submandinular gland
Sublingual gland
Key
Excretory
Striated
Intercalated
Intercalated duct:
P > M > L
Striated duct:
M > P > L
Ref: 1

30. Histology of ductal system
Excretory duct
Histology of ductal system
Serous demilune
Mixed acini
Striated duct 2
Intercalated duct 1
Myoepithelial cells
Mucous acini
Ref: 1

31. Histology of ductal system
Mixed alveolus
Mucous alveolus
Serous
alveolus
Serouis
demilune
Ref: 2

32. Histology of ductal system
Ref: 2

33. Histology of ductal system
Ref: 2

34. Histology of ductal system
Myoepithelial
cell
Mucous
Ref: 2

35. Histology of ductal system
Intercalated duct
Adipose tissue
Serous
acini
Myoepithelial
cell
Excretory duct
Ref: 5

36. Histology of ductal system
Ref: 5
Myoepithelial
cell
Serous
acini
Striated duct
Mixed
Mucous
acini

37. Histology of ductal system
Intralobular
duct
Blood
vessel
Ref: 2

38. Histology of ductal system
Scanning
electron
microscope
Myoepithelial
cell processes
Ref: 2

39. Histology of ductal system
Serous cell
Mucous cell
Ref: 2

40. Composition of saliva ml
Ref: 1

41. Composition of saliva
Ref: 2

42. Composition of saliva
Ref: 2

43. Function of saliva
3 pints = ? liter 1 2 3 4 5 6
Ref: 2

44. Function of saliva
Ref: 2

45. Function of saliva
Refs: 2, 4

46. Function of saliva
Ref: 2

47. Summaries Knowing: 1. Origins of salivary glands
2. Stages of development
3. Differentiation of terminal tubule cells
4. Cleft formation during salivary gland branching
5. Factors affecting branching of salivary gland cell cords
6. Classification of salivary gland cell cords
7. Classification, innervation, anatomy of major salivary gland
8. Classification, anatomy of minor salivary gland
9. Ductal system - components, comparison, histology
10. Saliva – composition, function