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口 腔 病 理 科口 腔 病 理 科 Salivary gland-embryology 唾液腺 - 胚胎學 陳玉昆副教授 : 高雄醫學大學 口腔病理科 07-3121101~2755

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Presentation on theme: "口 腔 病 理 科口 腔 病 理 科 Salivary gland-embryology 唾液腺 - 胚胎學 陳玉昆副教授 : 高雄醫學大學 口腔病理科 07-3121101~2755"— Presentation transcript:

1 口 腔 病 理 科口 腔 病 理 科 Salivary gland-embryology 唾液腺 - 胚胎學 陳玉昆副教授 : 高雄醫學大學 口腔病理科 07-3121101~2755 yukkwa@kmu.edu.tw

2 學 習 目 標學 習 目 標 1. Origins of salivary gland 2. Stages of development 3. Differentiation of terminal tubule cells 4. Cleft formation during salivary gland branching 5. Factors affecting branching of salivary gland cell cords 6. Classification of salivary gland cell cords 7. Classification, innervation, anatomy of major salivary gland 8. Classification, anatomy of minor salivary gland 9. Ductal system - components, comparison, histology 10. Saliva – composition, function 參考資料 References 1.Avery JK. Oral development and histology. 2 nd edition, Chapter 21, p. 352-81 2.Avery JK. Oral histology-a clinical approach. 1 st edition, Chapter 15, p. 184-95 3.Berkovitz BK, Holland GR, Moxham BH. 2 nd edition, p.215, 220 4. de Almeida PDV, et al.. Saliva Composition and Functions: A Comprehensive Review. J Contemp Dent Pract 2008 3:72-80 5. Kaohsiung Medical University, Oral Pathology Department

3 Origins of salivary gland 8th prenatal week 6th prenatal week Minor gland: 12 prenatal weeks Frontal section through developing face Epithelial outgrowth of buccal epithelium invading the underlying mesenchyme Epithelial outgrowth of buccal epithelium invading the underlying mesenchyme Nasal septum Tongue Parotid bud Sublingual bud Submandular bud 7th prenatal week Ref: 1

4 Stages of development Bud formation Stage I Ref: 1

5 Stages of development Stage II Cord growth Ref: 1

6 Stages of development Stage III Branching of cord Ref: 1

7 Stages of development Stage IV Lobule formation Ref: 1

8 Stages of development Stage V Canalization of cords to form ducts Ref: 1

9 Stages of development Lobule of gland Connective tissue septa Ref: 2

10 Stages of development Stage VI Cytodifferentiation Ref: 1

11 Differentiation of terminal tubule cells Terminal tubule cell Proacinar cell Intercalated duct cell (Stem cell) Acinar cells

12 Factors affecting branching of salivary gland cell cords Hyaluronidase Collagen Generalized cell proliferation No branching Basal lamina Branching Digest the collagen Ref: 1

13 Cleft formation during salivary gland branching ABC M BM E M = messenchyme BM = basement membrane E = epithelium Type IV Type III Type I Collagen Type Ref: 1

14 Classification of salivary gland cell cords Tubuloacinar type Exocrine - duct system for secretion transportation Tubular Tubulo- acinar Branching duct Main duct Grape-like acinar Ref: 1

15 Classification of salivary gland cell cords Method of secretory production Discharge Membrane Secretory granule Golgi Merocrine type secretory process Ref: 1

16 Classification- major salivary gland Size LocationCapsule (14-28g) (7-8g) (3g) Parotid gland Subman- dibular gland Sublingual gland Ref: 1

17 Anatomy - major salivary gland Stensen’s duct (7 cm long) Warthin’s duct (5 cm long) Bartholin’s duct (Rivinus’s ducts) Ref: 2

18 Classification- major salivary gland Type of secretion Contribution of saliva Striated duct intercalated duct Paro- tid gland Paro- tid gland Subman- dibular gland Sublin- gual gland % % % Refs: 1, 4

19 Classification - major salivary gland Parotid gland Sublingual gland Sublingual gland Submandinular gland Submandinular gland Sympathetic innervation Parasympathetic innervation PreganglionicPostganglionic Ref: 1

20 Innervation of salivary gland Parotid gland Sublingual gland Submandibular gland Auriculotemporal n Chorda tympani Otic ganglion Submandibular ganglion Superior cervical ganglion Superior salivary nucleus Inferior salivary nucleus VII IX Sympathetic Ref: 1 Parasympathetic

21 Anatomy- major salivary gland Facial nerve vs fetal parotid gland Ref: 1

22 Classification- major salivary gland Parotid gland Submandinular gland Sublingual gland Blood supply ArterialVenous Ref: 1

23 Anatomy - minor salivary gland Uncapsulated; named by location Ref: 2

24 Classification- minor salivary gland NameLocation Type of secretion Contribution of saliva : 5-10% Ref: 1

25 Classification- minor salivary gland Ref: 3 A: Small serous glands of von Ebner empty into the base of trench Taste buds Circumvallate papillae in longitudinal A A Taste buds

26 Ductal system Ref: 3 Acinus Capsule Septa Lobe Secretory Units Intercalated Striated Excretory Ducts

27 Ductal system Ref: 3 Intra-Lobular Striated duct Excretory duct Serous cell Serous demilune Mucous acinus Mucous cell Intercalcated duct Myoepithelial cell Inter-Lobular

28 Ductal system Oral cavity Major salivary gland duct orifice Oral epithelium Interlobular duct system Intralobular duct system Excretory duct Mucous acinus Mixed acinus Serous acinus Ref: 2

29 Comparison of ductal system Relative ductal length Parotid gland Submandinular gland Sublingual gland Key Excretory Striated Intercalated Intercalated duct: P > M > L Striated duct: M > P > L Ref: 1

30 Histology of ductal system Intercalated duct Excretory duct Myoepithelial cells Mucous acini Serous demilune Mixed acini Striated duct 1 2 Ref: 1

31 Histology of ductal system Mixed alveolus Mucous alveolus Serous alveolus Serouis demilune Ref: 2

32 Histology of ductal system Ref: 2

33 Histology of ductal system Ref: 2

34 Histology of ductal system Myoepithelial cell Myoepithelial cell Mucous cell Ref: 2

35 Histology of ductal system Ref: 5 Intercalated duct Myoepithelial cell Serous acini Excretory duct Adipose tissue

36 Histology of ductal system Ref: 5 Myoepithelial cell Serous acini Striated duct Mixed acini Mucous acini

37 Histology of ductal system Intralobular duct Blood vessel Ref: 2

38 Histology of ductal system Scanning electron microscope Myoepithelial cell processes Ref: 2

39 Histology of ductal system Serous cellMucous cell Ref: 2

40 Composition of saliva Ref: 1 ml

41 Composition of saliva Ref: 2

42 Composition of saliva Ref: 2

43 Function of saliva 1 2 3 4 5 6 Ref: 2 3 pints = ? liter

44 Function of saliva Ref: 2

45 Function of saliva Refs: 2, 4

46 Function of saliva Ref: 2

47 Summaries Knowing: 1. Origins of salivary glands 2. Stages of development 3. Differentiation of terminal tubule cells 4. Cleft formation during salivary gland branching 5. Factors affecting branching of salivary gland cell cords 6. Classification of salivary gland cell cords 7. Classification, innervation, anatomy of major salivary gland 8. Classification, anatomy of minor salivary gland 9. Ductal system - components, comparison, histology 10. Saliva – composition, function


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