1. PTENP1 serves as a ceRNA in the regulation of tumor growth in RCC
PTENP1 serves as a ceRNA in the regulation of tumor growth in RCC. A, cell proliferation in ACHN and SN12PM6 cells expressing miR21 or control.
PTENP1 serves as a ceRNA in the regulation of tumor growth in RCC. A, cell proliferation in ACHN and SN12PM6 cells expressing miR21 or control. Cell viability was quantified at each time point. miR21 promoted cell growth. Data are plotted as the mean ± SEM of three independent experiments. B, cell proliferation in ACHN and SN12PM6 cells expressing PTEN or control. Cell viability was quantified at each time point. PTEN suppressed cell growth. C, cell proliferation in ACHN and SN12PM6 cells expressing vector control or PTENP1 or miR21 or miR21 and PTENP1. Cell viability was quantified at each time point. PTENP1 reversed the promotion of cell growth by miR21. D, we designed five groups in the animal models, and then ACHN cells expressing vector control or miR21 or PTEN, or PTENP1 or coexpressing miR21 and PTENP1 were transplanted into mice. D, the size of transplanted tumors in different groups (a). Tumor weight of each mouse at the end of 41 days is indicated (b). Tumor volumes were determined at each time point (c). PTEN and PTENP1 suppressed tumor growth in vivo. miR21 promoted tumor growth in vivo. PTENP1 rescued the promotion of tumor growth by miR21. These data mean PTENP1 serves as a ceRNA in the regulation of tumor growth in RCC. **, P < 0.01.
Gan Yu et al. Mol Cancer Ther 2014;13:
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