1. THE PREMIER GLOBAL INFECTIOUS DISEASE KNOWLEDGE MANAGEMENT SYSTEM www.GIDEONonline.com Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com

2. D IAGNOSIS D ISEASES T RAVEL D RUGS V ACCINES I NFECTIOUS D ISEASES M ODULE

3. Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com …and Disease comparisons D IAGNOSIS …Country of acquisition and presumed incubation periods …Suggestions With over 200 signs and symptoms… Continue for GIDEONs step-by-step program demonstration I NFECTIOUS D ISEASES M ODULE

4. Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com What is your diagnosis?... A 55 year old American photographer returned home after a six-week trip to the game parks of Tanzania. Four weeks after return, he developed headache, myalgia, arthralgia, weight loss and intermittent fever. The patient is noticeably confused and distracted, and physical examination reveals hepatosplenomegaly and lymphadenopathy in the supraclavicular and cervical regions. The hemogram is normal, but the cerebrospinal fluid contains 20 lymphocytes per mm3. I NFECTIOUS D ISEASES M ODULE

5. Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com Main Diagnosis Page I NFECTIOUS D ISEASES M ODULE

6. We can then add information such as: … and Incubation period Click to select that a symptom is present and to specify that a symptom is not present Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com Country of acquisition… The diagnosis updates after each selection Select symptoms and signs, country of acquisition, incubation period. I NFECTIOUS D ISEASES M ODULE

7. The results from GIDEON indicate that our photographer has HIV infection – initial illness. With these results we can: Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com Run a disease comparison by selecting the diseases we wish to compare and pressing the Compare button Click on a disease name to view more detailed information I NFECTIOUS D ISEASES M ODULE

8. We can also use the results from GIDEON to: Ask GIDEON to explain why a certain disease does not appear in the results by clicking on the Why Not button Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com Save the results Print the results Email the results Next, we explore the use of the Disease tab in the Infectious Diseases Module I NFECTIOUS D ISEASES M ODULE

9. D ISEASES With over 30,000 graphs and images available for presentations & lectures… Generates disease lists compatible with any combination of vector, vehicle, reservoir, agent and country. This module follows the real-time status of every disease in every country ! Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com I NFECTIOUS D ISEASES M ODULE

10. …and images Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com D ISEASES The Clinical tab offers a wealth of information on the signs, symptoms, laboratory abnormalities... and much more We can also display distribution information by clicking on theDistribution tab Display general information by selecting it from the disease list below This module also includes graphs… I NFECTIOUS D ISEASES M ODULE

11. I NTERACTIVE M APS In the Infectious Diseases module you can find and display interactive distribution maps To start click on the globe icon below Which then displays the following distribution map: I NFECTIOUS D ISEASES M ODULE

12. For country-specific information, we can zoom in on Sudan… …and when we click the red dot, individual country notes will appear Find country-specific distribution maps and information I NFECTIOUS D ISEASES M ODULE

13. The Infectious Diseases Module has a wealth of information about diseases abroad and travelers health concerns …and health warnings, guidelines and disease information worldwide T RAVEL …Country-specific traveler information Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com Information for medical professionals… I NFECTIOUS D ISEASES M ODULE

14. V ACCINES D RUGS The Infectious Diseases Module also includes a wealth of information about drugs and vaccines Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com General information on specific drugs and vaccines Drug warnings, contraindications and potential interactions Listings of all known drug and vaccine trade names I NFECTIOUS D ISEASES M ODULE

15. R ANKED I DENTIFICATION R ESULTS P ATHOGEN I NFORMATION P ATHOGEN C OMPARISON Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com Identification and Characterization Modules for: M ICROBIOLOGY M ODULE MYCOBACTERIA AND YEASTS B ACTERIA

16. Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com A 47 year old man is found to have a large abscess in his left leg. Routine cultures reveal a branched, aerobic, non-sporulating, gram-positive bacillus. To explore the Microbiology module we will refer to one of our recent example cases: Creative DeBugging M ICROBIOLOGY M ODULE What procedure should the laboratory perform at this point?... What micro-organisms should be considered?...

17. Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com First, phenotypic tests were entered into the Microbiology module: To determine the most discriminative laboratory test to perform, look at Suggestions. For a longer list: check all of the organisms, and press Compare To determine the most discriminative laboratory test to perform, look at Suggestions. For a longer list: check all of the organisms, and press Compare The organism in question appears to be one of several species of Nocardia As we see in this screen, GIDEON recommends that we examine Catalase, Glycerol, and Glucose fermenter [top three tests]. Our identification criteria gave us these results: M ICROBIOLOGY M ODULE

18. Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com M ICROBIOLOGY M ODULE By clicking on the pathogen name we can display further information on the selection …Our organism was positive for all three of the additional tests. After re-identifying the organism using those results we can see in this screen that the most likely identification in this case is Nocardia asteroides. …Our organism was positive for all three of the additional tests. After re-identifying the organism using those results we can see in this screen that the most likely identification in this case is Nocardia asteroides. Phenotype information can be displayed by clicking on the Phenotype tab in this display

19. N EW T OXICOLOGY M ODULE D IAGNOSIS D ISEASES I DENTIFICATION A GENTS Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com Occupational Toxicology: Diseases contracted at the workplace T OXICOLOGY M ODULE

20. We input information such as: Then, press the Diagnose button to see results! First, we select the signs and symptoms: Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com D IAGNOSIS Nature of Onset… …Latency …Medical findings …Job Tasks …and Occupations T OXICOLOGY M ODULE

21. And, we input information such as: Then, press the Identify button to see results! Again, we select the signs and symptoms: Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com Agent categories… …Adverse effects …Industrial processes …and Home activities I DENTIFY A list of possible agents is given, with more information about each T OXICOLOGY M ODULE

22. D ISEASES Input known information from drop-down menus With relevant information about highlighted disease Results are shown in the box below… Disease Category… …Jobs …Syndromes …and Latency T OXICOLOGY M ODULE Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com

23. A GENTS Again, we input known information from drop-down menus With relevant information about highlighted disease Results are shown in the box below… Agent category… …Processes …Activities T OXICOLOGY M ODULE Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com

24. W HY U SE GIDEON? Improve Patient Care… Quickly and accurately generate a ranked differential diagnosis Quickly access disease information including current outbreak data Obtain drug & vaccine treatment guidelines for adult and pediatric patients Enable the lab to accurately identify the infectious agent from patient samples WHO USES GIDEON? Among others… Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com Any clinician treating a patient with a possible infection Emergency Room Doctors Pediatricians Infectious Disease Doctors The Clinical Laboratory Internists Medical Educators

25. Including: is currently being utilized by hospitals, universities, travel clinics, medical professionals, government health agencies and private corporations worldwide… Copyright © 2010 GIDEON Informatics, Inc. All rights reserved www.GIDEONonline.com

26. www.GIDEONonline.com