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Antonino Forabosco, M.D., Ph.D., Chiarella Sforza, M.D., Ph.D. 

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Presentation on theme: "Antonino Forabosco, M.D., Ph.D., Chiarella Sforza, M.D., Ph.D. "— Presentation transcript:

1 Establishment of ovarian reserve: a quantitative morphometric study of the developing human ovary 
Antonino Forabosco, M.D., Ph.D., Chiarella Sforza, M.D., Ph.D.  Fertility and Sterility  Volume 88, Issue 3, Pages (September 2007) DOI: /j.fertnstert Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Human ovaries during fetal development. (A, B) 17-week-old fetus. The arrows indicate the ovigerous cords (clusters of primitive cortical tissue); asterisks: primordial follicles. Scale bar, 50 μm. (C) 20-week-old fetus. Under the ovarian surface, some ovigerous cords are encircled by white broken lines; deeper in the cortex primordial follicles are indicated by white arrowheads. Scale bar, 50 μm. (D) 20-week-old fetus. At higher magnification, the developing primordial follicles are indicated by white arrowheads; some ovigerous cords are encircled by white broken lines. Scale bar, 100 μm. (E) 25-week-old fetus. Developing primordial follicles. Scale bar, 100 μm. (F) 25-week-old fetus. Detail of developing primordial follicles. Scale bar, 100 μm. Forabosco. Formation of ovarian reserve in humans. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Neonatal human ovaries. (A) Under the ovarian surface, some ovigerous cords are encircled by white broken lines; deeper in the cortex primordial follicles are indicated by an asterisk. Scale bar, 100 μm. (B) Primordial follicles. Scale bar, 100 μm. (C) At higher magnification, primordial follicles. Scale bar, 20 μm. (D) Primary follicle encircled by cuboidal or low columnar granulosa cells. Scale bar, 20 μm. (E) Antral or Graafian follicle with fluid-filled spaces among the multilayered cuboidal granulosa cells coalescing. Scale bar, 100 μm. (F) Secondary or multilaminar follicle (F2) and antral follicle (AF). Scale bar, 100 μm. Forabosco. Formation of ovarian reserve in humans. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions


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