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Marilyn J. Cipolla, MS, Christian T. Harker, PhD, John M. Porter, MD 

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Presentation on theme: "Marilyn J. Cipolla, MS, Christian T. Harker, PhD, John M. Porter, MD "— Presentation transcript:

1 Endothelial function and adrenergic reactivity in human type-II diabetic resistance arteries 
Marilyn J. Cipolla, MS, Christian T. Harker, PhD, John M. Porter, MD  Journal of Vascular Surgery  Volume 23, Issue 5, Pages (May 1996) DOI: /S (96) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 A, Dose-response curves to norepinephrine of intact nondiabetic control (closed circles) and diabetic (closed triangles) subcutaneous arteries. Diabetic arteries were significantly more sensitive to norepinephrine than nondiabetic control arteries (p < 0.05). EC50 values are given in text. B, Dose-response curves to norepinephrine of intact (closed circles) and denuded (open circles) subcutaneous arteries from control subjects without diabetes. Removal of endothelium significantly increased sensitivity to norepinephrine (p < 0.05). EC50 values are given in text. C, Dose-response curves to norepinephrine of intact (closed triangles) and denuded (open triangles) subcutaneous arteries from patients with type II diabetes. Denuded arteries had similar sensitivity as intact arteries to norepinephrine, and no significant difference was found between EC50 values, which are given in text. Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 1 A, Dose-response curves to norepinephrine of intact nondiabetic control (closed circles) and diabetic (closed triangles) subcutaneous arteries. Diabetic arteries were significantly more sensitive to norepinephrine than nondiabetic control arteries (p < 0.05). EC50 values are given in text. B, Dose-response curves to norepinephrine of intact (closed circles) and denuded (open circles) subcutaneous arteries from control subjects without diabetes. Removal of endothelium significantly increased sensitivity to norepinephrine (p < 0.05). EC50 values are given in text. C, Dose-response curves to norepinephrine of intact (closed triangles) and denuded (open triangles) subcutaneous arteries from patients with type II diabetes. Denuded arteries had similar sensitivity as intact arteries to norepinephrine, and no significant difference was found between EC50 values, which are given in text. Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 1 A, Dose-response curves to norepinephrine of intact nondiabetic control (closed circles) and diabetic (closed triangles) subcutaneous arteries. Diabetic arteries were significantly more sensitive to norepinephrine than nondiabetic control arteries (p < 0.05). EC50 values are given in text. B, Dose-response curves to norepinephrine of intact (closed circles) and denuded (open circles) subcutaneous arteries from control subjects without diabetes. Removal of endothelium significantly increased sensitivity to norepinephrine (p < 0.05). EC50 values are given in text. C, Dose-response curves to norepinephrine of intact (closed triangles) and denuded (open triangles) subcutaneous arteries from patients with type II diabetes. Denuded arteries had similar sensitivity as intact arteries to norepinephrine, and no significant difference was found between EC50 values, which are given in text. Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

5 Fig. 2 A, Dose-response curves to norepinephrine of intact subcutaneous arteries in absence (closed circles) and presence (open circles) of nitric oxide inhibitor L-NNA (0.1 mmol/L) from control subjects without diabetes. Inhibition of NO caused significant increase in sensitivity to norepinephrine similar to endothelial removal. EC50 values are given in text. B, Dose-response curves to norepinephrine of intact subcutaneous arteries in absence (closed triangles) and presence (open triangles) of nitric oxide inhibitor L-NNA (0.1 mmol/L) from patients with type II diabetes. Inhibition of NO did not affect sensitivity to norepinephrine in diabetic arteries. EC50 values are given in text. Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

6 Fig. 2 A, Dose-response curves to norepinephrine of intact subcutaneous arteries in absence (closed circles) and presence (open circles) of nitric oxide inhibitor L-NNA (0.1 mmol/L) from control subjects without diabetes. Inhibition of NO caused significant increase in sensitivity to norepinephrine similar to endothelial removal. EC50 values are given in text. B, Dose-response curves to norepinephrine of intact subcutaneous arteries in absence (closed triangles) and presence (open triangles) of nitric oxide inhibitor L-NNA (0.1 mmol/L) from patients with type II diabetes. Inhibition of NO did not affect sensitivity to norepinephrine in diabetic arteries. EC50 values are given in text. Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

7 Fig. 3 Dose-response curves to acetylcholine of intact subcutaneous arteries from control subjects without diabetes (closed circles) and patients with type II diabetes (closed triangles). Diabetic arteries were more sensitive to relaxations evoked by this agonist. EC50 values are given in text. Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

8 Fig. 4 Dose-response curves to sodium nitroprusside of intact subcutaneous arteries from control subjects without diabetes (closed circles) and patients with type II diabetes (closed triangles). No significant differences were found between nondiabetic control and diabetic arteries. EC50 values are given in text. Journal of Vascular Surgery  , DOI: ( /S (96) ) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

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