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Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium- dependent mechanism  Marilyn J. Cipolla, PhD, Alexander Nicoloff, MD,

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Presentation on theme: "Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium- dependent mechanism  Marilyn J. Cipolla, PhD, Alexander Nicoloff, MD,"— Presentation transcript:

1 Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium- dependent mechanism  Marilyn J. Cipolla, PhD, Alexander Nicoloff, MD, Tessio Rebello, PhD, Anthony Amato, MD, John M. Porter, MD  Journal of Vascular Surgery  Volume 29, Issue 6, Pages (June 1999) DOI: /S (99)70251-X Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 Diameter tracing of an intact human subcutaneous artery contracted with norepinephrine and given increasing concentrations of propionyl-L-carnitine. Note that propionyl-L-carnitine caused concentration-dependent vasodilation of this artery. Journal of Vascular Surgery  , DOI: ( /S (99)70251-X) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Diameter tracing of a denuded human subcutaneous artery contracted with norepinephrine and given increasing concentrations of propionyl-L-carnitine. Note that propionyl-L-carnitine had considerably less effect on the diameter of this artery. Journal of Vascular Surgery  , DOI: ( /S (99)70251-X) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Graph of the concentration-response curves to propionyl-L-carnitine of intact, intact and in the presence of 0.1 mmol/L L-NNA or 10.0 μmol/L indomethacin, and denuded human arteries. Note that propionyl-L-carnitine caused concentration-dependent vasodilation in intact arteries, but had little effect on deendothelialized arteries. Arteries in the presence of L-NNA dilated to a similar degree as intact arteries; however, the presence of indomethacin significantly reduced this vasodilation. *P < .05; **P < .01 vs. intact. Journal of Vascular Surgery  , DOI: ( /S (99)70251-X) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

5 Fig. 4 Graph of the percent dilation of intact, intact and in the presence of 0.1 mmol/L nitro-L-arginine or 10.0 mmol/L indomethacin, and denuded human arteries in the highest concentration of propionyl-L-carnitine (10–4 mol/L). ** P < .01 vs. intact. Journal of Vascular Surgery  , DOI: ( /S (99)70251-X) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

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