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This Month in Gastroenterology
Jan Tack, John M. Carethers Gastroenterology Volume 140, Issue 1, Pages 1-4 (January 2011) DOI: /j.gastro Copyright © 2011 AGA Institute Terms and Conditions
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Figure 1 (A) Schematic of the distensibility protocol. (B) Examples of pressure–cross-sectional area relationships in a control subject and in an eosinophilic esophagitis patient with diffusely narrowed distal esophagus. Gastroenterology , 1-4DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions
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Figure 2 Comparison between controls and Crohn's disease (CD) in bone volume (A), trabecular thickness (B), mineral apposition rate (C), and bone formation rate (D). Gastroenterology , 1-4DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions
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Figure 3 Expression levels of miR-1 and miR-133 in the stomachs of mice with H pylori infection. (A) Expression levels of miR-1, miR-133a, and miR-133b were analyzed by quantitative reverse transcriptase polymerase chain reaction using the TaqMan microRNA assay in the stomachs of control (blank bar; n = 7) and H pylori–infected mice (filled bar; n = 7). Expression levels were normalized against U6 RNA expression. All reactions were done in duplicate and expressed as mean values ± standard deviations. *P < .005 compared with controls. (B) Expression levels of miR-1, miR-133a, and miR-133b in clinical samples from the gastric antrum of patients with or without H pylori infection. Expression levels of miR-1, miR-133a, and miR-133b were significantly decreased in patients positive for H pylori infection (n = 14), relative to patients who were negative (n = 8; miR-1, P < .005; miR-133a, P < .05; miR-133b, P < .01). Gastroenterology , 1-4DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions
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Figure 4 Characterization of hepatic stem cell marker expressions in Hep3B cells. The majority of ATP-dependent binding cassette (ABC)B5+ cells are also GEP+, and these GEP+ABCB5+ double positive expressed CD133 and EpCAM, both stem cell markers. Suppression of ABCB5 by the siRNA approach effectively decreased ABCB5 expression, reduced the population of cells co-expressing GEP, and diminished the cell population expressing the hepatic stem cell markers CD133 and EpCAM. Gastroenterology , 1-4DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions
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