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This Month in Gastroenterology

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Presentation on theme: "This Month in Gastroenterology"— Presentation transcript:

1 This Month in Gastroenterology
Jan Tack, John M. Carethers  Gastroenterology  Volume 136, Issue 4, Pages (April 2009) DOI: /j.gastro Copyright © 2009 AGA Institute Terms and Conditions

2 Figure 1 (A) Incidence rates of perforated colonic diverticular disease per 100,000 person-years. (B) Kaplan–Meier survival curve for the disease cohort and the age-and gender-matched population cohort. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

3 Figure 2 (A) Age-specific incidence of definite gastroparesis in Olmsted County, Minnesota, 1996–2006. (B) Survival of subjects with definite gastroparesis cohort in Olmsted County, 1996–2006, and expected survival of gender- and age-matched Minnesota whites in 2000. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

4 Figure 3 Quantitative analysis of mouse PanIN lesions in 6 week LSL-KrasG12D/+/Mist1Cre-ER/+, and LSL-KrasG12D/+/Mist1Cre-ER/Cre-ER mice treated with tamoxifen (n = 4). Note the large increase in all mouse PanIN grades in LSL-KrasG12D/+/Mist1Cre-ER/Cre-ER (Mist1KO) mice. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

5 Figure 4 UDCA, by increasing VDR protein expression through ERK activation, induces cathelicidin expression in biliary epithelial cells. When UDCA and vitamin D are used in combination, the induction of cathelicidin expression is potentiated. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions


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