1. Nat. Rev. Neurol. doi:10.1038/nrneurol.2015.194
Figure 1 Illustration of tissue and lesion appearance on conventional and nonconventional MRI
Figure 1 | Illustration of tissue and lesion appearance on conventional and nonconventional MRI. In a young female patient with RRMS, a | T2-FLAIR MRI reveals macroscopic acute (thick arrow) and chronic (thin arrows) MS lesions with high sensitivity; however, b | postcontrast T1-weighted images are needed to identify the ring-enhancement that is typical of acute lesions owing to the breakdown of the blood–brain barrier. c | Microstructural tissue changes can be quantified with MTI, which shows a reduction of the magnetization transfer ratio at the site of the active lesion. Note the different appearance of the lesion on each of these three maps. DTI reveals d | reduced fractional anisotropy and e | increased mean diffusivity in this patient. f | SWI can be used to assess regional iron accumulation, and highlights the venous structures seen in relation to MS lesions. Abbreviations: DTI, diffusion tensor imaging; FLAIR, fluid-attenuated inversion recovery; MS, multiple sclerosis; MTI, magnetization transfer imaging; RRMS, relapsing–remitting MS; SWI, susceptibility-weighted imaging.
Enzinger, C. et al. (2015) Nonconventional MRI and microstructural cerebral changes in multiple sclerosis
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