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Figure 1 Perivenous distribution of multiple sclerosis lesions
Figure 1 | Perivenous distribution of multiple sclerosis lesions. 3 T FLAIR* (combined T2*-weighted MRI and fluid-attenuated inversion recovery) images from four individuals with a variety of neurological conditions, who were scanned at different sites. In the patients with relapsing–remitting or primary progressive multiple sclerosis (MS), a central vessel is visible in most hyperintense lesions (data from the NIH cohort). The dark veins are located centrally in the lesion and can be visualized in at least two perpendicular planes (arrows in magnified boxes). On the other hand, a central vein is absent from most of the lesions (arrowheads in magnified boxes) in the patient with migraine (University of Vermont cohort) and the patient with ischaemic small vessel disease (University of Nottingham cohort). Sati, P. et al. (2016) The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative Nat. Rev. Neurol. doi: /nrneurol
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