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Hyperglycemia limits experimental aortic aneurysm progression

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Presentation on theme: "Hyperglycemia limits experimental aortic aneurysm progression"— Presentation transcript:

1 Hyperglycemia limits experimental aortic aneurysm progression
Noriyuki Miyama, MD, PhD, Monica M. Dua, MD, Janice J. Yeung, MD, Geoffrey M. Schultz, MD, Tomoko Asagami, MD, PhD, Eiketsu Sho, MD, PhD, Mien Sho, MD, PhD, Ronald L. Dalman, MD  Journal of Vascular Surgery  Volume 52, Issue 4, Pages (October 2010) DOI: /j.jvs Copyright © 2010 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Aortic diameters in (A) PPE vs PPE-DM mice (†P = .0016, POD 7; ‡P < .0001, POD 14) and (B) ANG vs ANG-DM mice (*P = .0474, POD 14; *P = .0472, POD 21). The range bars show the standard deviation. ANG, angiotensin II; DM, diabetes mellitus; POD, postoperative day; PPE, porcine pancreatic elastase. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Representative images of CD31 staining in (A) PPE and (B) PPE-DM (original magnification ×400). AD, adventitia; Ao, aorta; M, media. C, Number of medial and adventitial CD31+ vessels (A and B, black arrows) per high power field (HPF). The range bars show the standard deviation. *P < vs PPE; small circles represent individual data points, large circle represents mean of cohort. D, Correlation between neovessel density and aortic diameter, Y = 29.68X – 17.86; correlation coefficient, R = 0.794; P < .0001; PPE (n = 9), PPE-DM (n = 10). DM, Diabetes mellitus; PPE, porcine pancreatic elastase. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Representative images of MAC-2 staining in (A) PPE and (B) PPE-DM (original magnification ×200). M, Media. C, Number of mural MAC-2+ cells per cross-section are shown. The range bars show the standard deviation. *P = vs PPE. D, Correlation between macrophage density and aortic diameter, Y = X – ; correlation coefficient, R = , P < E, Correlation between macrophage and neovessel density, Y = 9.53X ; correlation coefficient R = .662; P < .01. Data for D and E are from PPE (n = 9) and PPE-DM (n = 10) mice. DM, Diabetes mellitus; PPE, porcine pancreatic elastase. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

5 Fig 4 A representative image of (A) zymographic and densitometric analysis of (B) pro-MMP-9, (C) pro-MMP-2, and (D) active MMP-2. *P = vs PPE. Representative images of Elastica-Masson-stained aortic cross-sections in (E) PPE (F) and PPE-DM (original magnification ×200), and (G) the ratio of stained-elastin-area to media-area. *P = vs PPE. DM, Diabetes mellitus; MMP, matrix metalloproteinase; PPE, porcine pancreatic elastase. The range bars show the standard deviation. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

6 Fig 5 Comparison of aortic diameter at baseline and after porcine pancreatic elastase (PPE) infusion in PPE (n = 6; white bar), PPE-DM (n = 6; grey bar) and PPE-DM + insulin (n = 6; black bar) mice (POD 7 *P =.0014, #P <.0001; POD 14 *P =.0036, #P = .0002). The range bars show the standard deviation. DM, Diabetes mellitus; POD, postoperative day. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

7 Fig 6 Comparison of peritoneal macrophages in lavage solution from diabetes mellitus (DM) mice and control mice with thioglycollate-induced peritonitis. *P = .0171, #P < The range bars show the standard deviation. NS, No significance; thio, thioglycollate; VEGF, vascular endothelial growth factor; WT, wild type. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

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