Download presentation
Presentation is loading. Please wait.
1
Obesity, inflammation, and liver cancer
Beicheng Sun, Michael Karin Journal of Hepatology Volume 56, Issue 3, Pages (March 2012) DOI: /j.jhep Copyright © 2011 European Association for the Study of the Liver Terms and Conditions
2
Fig. 1 Three putative mechanisms for obesity-induced and obesity-promoted hepatocarcinogenesis. ROS, reactive oxygen species; RNS, reactive nitrogen species. Journal of Hepatology , DOI: ( /j.jhep ) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions
3
Fig. 2 Adipokines, cytokines, and hepatocarcinogenesis. Excessive free fatty acids (FFAs) can activate various immune cells and cause hepatocytes cell death. Moreover, cell debris, pro-inflammatory cytokines and adipokines can further enhance TNF and IL-6 secretion from Kupffer cells, leading to activation of downstream signaling molecules, such as STAT3 in hepatocytes which contribute to hepatocarcinogenesis. Journal of Hepatology , DOI: ( /j.jhep ) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions
4
Journal of Hepatology 2012 56, 704-713DOI: (10. 1016/j. jhep. 2011. 09
Copyright © 2011 European Association for the Study of the Liver Terms and Conditions
5
Journal of Hepatology 2012 56, 704-713DOI: (10. 1016/j. jhep. 2011. 09
Copyright © 2011 European Association for the Study of the Liver Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com Inc.
All rights reserved.