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FoxO: A New Addition to the ESC Cartel

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Presentation on theme: "FoxO: A New Addition to the ESC Cartel"— Presentation transcript:

1 FoxO: A New Addition to the ESC Cartel
Kevin Andrew Uy Gonzales, Huck-Hui Ng  Cell Stem Cell  Volume 9, Issue 3, Pages (September 2011) DOI: /j.stem Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Models for the Transcriptional Regulatory Network in Human and Mouse ESCs (A) In hESCs, FOXO1 directly upregulates OCT4 and SOX2 expression. (B) Foxo1 and Foxo3 are implicated in the maintenance of the mESC state. Comprehensive determination of the FoxOs' target genes in ESCs would enable a global understanding of their integration into the pluripotency network, as well as provide new insights into species-specific circuitries. Cell Stem Cell 2011 9, DOI: ( /j.stem ) Copyright © 2011 Elsevier Inc. Terms and Conditions


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