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MicroRNA-124: Micromanager of Neurogenesis

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Presentation on theme: "MicroRNA-124: Micromanager of Neurogenesis"— Presentation transcript:

1 MicroRNA-124: Micromanager of Neurogenesis
Thales Papagiannakopoulos, Kenneth S. Kosik  Cell Stem Cell  Volume 4, Issue 5, Pages (May 2009) DOI: /j.stem Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 miR-124 Positively Regulates Adult SVZ Neurogenesis
In a sagittal section of an adult mouse brain, adult neurogenesis occurs from the SVZ through the RMS, ultimately ending at the OB. miR-124 expression increases (red gradient) as the migratory differentiation cascade gives rise to neurons. miR-124 exerts its effect by targeting Sox9 and other repressors of neurogenesis. REST represses miR-124 expression in the SVZ progenitor pool. Cell Stem Cell 2009 4, DOI: ( /j.stem ) Copyright © 2009 Elsevier Inc. Terms and Conditions


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